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⊟Summary[edit | edit source]
- pan ID?: SAUPAN006014000
- symbol?: —
- synonym:
- description?: prevent-host-death protein
- prevent-host-death protein
- addiction module antitoxin
- antitoxin, putative
- type II toxin-antitoxin system Phd/YefM family antitoxin
- prevent-host-death family protein
- addiction module, antitoxin
- addiction module antitoxin, Axe family
- prevent-host-death family antitoxin
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 6073510..6074158
- synteny block?: BlockID0047580
- occurrence?: in 82% of 33 strains
yefM2 (axe2): type II addiction module ribosome-dependent RNase 2 antitoxin [1]
There is a crystal structure: 7V6W
Under normal conditions, YefM2 sequesters YoeB2 rendering it inert. Under stress conditions, TrfA-augmented ClpCP proteolyzes YefM2, YoeB2 binds to active ribosomes and cleaves messenger RNA transcripts near the start codon resulting in de novo translation shutdown.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_2394
08BA02176:
—
11819-97:
MS7_2471
6850:
RSAU_002296
71193:
—
ECT-R 2:
ECTR2_2315
ED133:
SAOV_2508c
ED98:
SAAV_2524
HO 5096 0412:
SAEMRSA15_23560
JH1:
SaurJH1_2533
JH9:
SaurJH9_2484
JKD6008:
SAA6008_02499 (stbD)
JKD6159:
SAA6159_02355 (stbD)
LGA251:
SARLGA251_22380
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS2349
Mu3:
SAHV_2441
Mu50:
SAV2457
MW2:
MW2381
RF122:
SAB2340c
ST398:
—
T0131:
SAT0131_02657 (rnhB)
TCH60:
HMPREF0772_10731
TW20:
SATW20_25860
USA300_TCH1516:
USA300HOU_2447
VC40:
SAVC_11160
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGT
N315 MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGT
NCTC8325 MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGT
Newman MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGT
USA300_FPR3757 MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGT
************************************************************
COL MDKVREREKDNSGTTNIDDIDWDNL
N315 MDKVREREKDNSGTTNIDDIDWDNL
NCTC8325 MDKVREREKDNSGTTNIDDIDWDNL
Newman MDKVREREKDNSGTTNIDDIDWDNL
USA300_FPR3757 MDKVREREKDNSGTTNIDDIDWDNL
*************************
- ↑ Xinyu Qi, Kimberly M Brothers, Dongzhu Ma, Jonathan B Mandell, Niles P Donegan, Ambrose L Cheung, Anthony R Richardson, Kenneth L Urish
The Staphylococcus aureus toxin-antitoxin system YefM-YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation.
J Bone Jt Infect: 2021, 6(7);241-253
[PubMed:34262845] [WorldCat.org] [DOI] (P e)Christopher F Schuster, Ralph Bertram
Toxin-Antitoxin Systems of Staphylococcus aureus.
Toxins (Basel): 2016, 8(5);
[PubMed:27164142] [WorldCat.org] [DOI] (I e)Niles P Donegan, Earl T Thompson, Zhibiao Fu, Ambrose L Cheung
Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus.
J Bacteriol: 2010, 192(5);1416-22
[PubMed:20038589] [WorldCat.org] [DOI] (I p)