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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus USA300_FPR3757
  • locus tag: SAUSA300_0506 [new locus tag: SAUSA300_RS02710 ]
  • pan locus tag?: SAUPAN002286000
  • symbol: nupC
  • pan gene symbol?: nupC
  • synonym:
  • product: pyrimidine nucleoside transport protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SAUSA300_0506 [new locus tag: SAUSA300_RS02710 ]
  • symbol: nupC
  • product: pyrimidine nucleoside transport protein
  • replicon: chromosome
  • strand: -
  • coordinates: 565191..566405
  • length: 1215
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGCATATTCTAATTGGGATTATCGGAATTATCTTCTTTTTAGCACTTGCGTTTCTATTT
    AGCTCAGACAGGAAAAATATTCGCTGGAAATATGTAGGAATTTTACTTGCAATTCAGCTT
    ATCTTTGCATTTATCTTGCTTAAAACTACAATGGGAATCAAGGTTATTGGTGGTATTTCA
    AACGGTTTTAACTACTTATTATTAAAAGCAGCAGATGGTGTTAACTTTGTATTCGGTGGT
    ATTCAATATATCGATCCTAAGCAACCACCATTCTTCTTCAGTGTATTATTACCTATCGTA
    TTTATTTCAGCGATTATCGGTATCCTTCAATACACAAAGATTTTACCTTTAATCATTAAT
    GTTTTAGGATTCTTAATTTCTAAAATTAATGGTATGGGACGTTTAGAATCATACAATGCA
    GTTGCTGCAGCAATTTTGGGACAATCTGAAGTATTTATTTCAATTAAAAAACAATTACCA
    TACATACCTAAGCAACGTTTATACACATTAACAGCTTCAGCAATGTCGACTGTTTCTGCT
    TCAATTATCGGTGCATACTTTACCTTAATTGAACCTAAATATGTTGTAACGGCTGTTGTC
    TTAAACTTATTTGGTGGTTTCATCATCGCTTCAATTATTAACCCTTATAAAGTTAATGAA
    GAAGATGACAAATTATTAGTTGAAGAAACTGAAGAAAGACAACAATCATTCTTCGAAATG
    CTAGGAGAATATATTTTAGATGGATTTAAAGTAGCTGTCATTGTAGGCGCAATGTTAATC
    GGATACATTGCCATTATCGCTCTATTAAATGGAATTGTAAGCAATATCTTTAGTACAGTT
    TCAGGTGGCGCTATTTCTTGGGATTTCCAAACATTAATTGGTTTTGTCTTTGCACCATTT
    GCATTCTTAGTCGGTGTGCCATGGCAAGATGCAGTTCAAGCCGGTTCAGTTATGGCGACA
    AAACTATTATCTAACGAATTTGTAGCAATGCAAGCACTTGGTAAACTTAGTGATTTATCT
    GAACACGCAAAAGGTGTTACATCTGTATTCTTAGTATCATTTGCTAACTTTAGCTCTATC
    GGTATTATTTCAGGTGCGATTAAATCACTTAATGACAAAAAAGGAGATACAGTTGCCCGC
    TTTGGTTTGAAATTATTATTCGGTGCAACACTAGTATCTTTCATTTCAGCTGCAATCGCT
    GGATTCTTTATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1215

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SAUSA300_0506 [new locus tag: SAUSA300_RS02710 ]
  • symbol: NupC
  • description: pyrimidine nucleoside transport protein
  • length: 404
  • theoretical pI: 9.44764
  • theoretical MW: 43804.7
  • GRAVY: 0.870792

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Nucleosides, purines and pyrimidines nucleoside transporter, NupC family (TIGR00804; HMM-score: 433.4)
  • TheSEED  :
    • Na+ dependent nucleoside transporter NupC
    Carbohydrates Monosaccharides Deoxyribose and Deoxynucleoside Catabolism  Nucleoside permease NupC
    and 1 more
    Nucleosides and Nucleotides Purines Xanthine Metabolism in Bacteria  Nucleoside permease NupC
  • PFAM:
    no clan defined Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus (PF07662; HMM-score: 210.9)
    and 2 more
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus (PF01773; HMM-score: 75.6)
    Gate; Nucleoside recognition (PF07670; HMM-score: 25)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 10
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0
    • Signal peptide possibility: -0.5
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011503
    • TAT(Tat/SPI): 0.000267
    • LIPO(Sec/SPII): 0.060914
  • predicted transmembrane helices (TMHMM): 10

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGISNGFNYLLLKAADGVNFVFGGIQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIINVLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLPYIPKQRLYTLTASAMSTVSASIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEMLGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPFAFLVGVPWQDAVQAGSVMATKLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSIGIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIAGFFI

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Carbon catabolism; RegPrecise 

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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