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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

organism: Staphylococcus aureus USA300_FPR3757
locus tag: SAUSA300_RS06865 [old locus tag: SAUSA300_1264 ]
pan locus tag^?: SAUPAN003764000
symbol: SAUSA300_RS06865
pan gene symbol^?: trpD
synonym:
product: anthranilate phosphoribosyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

type: CDS
locus tag: SAUSA300_RS06865 [old locus tag: SAUSA300_1264 ]
symbol: SAUSA300_RS06865
product: anthranilate phosphoribosyltransferase
replicon: chromosome
strand: +
coordinates: 1392382..1393380
length: 999
essential: unknown other strains

⊟Accession numbers[edit | edit source]

Location: NC_007793 (1392382..1393380) NCBI
BioCyc: SAUSA300_RS06865 BioCyc
MicrobesOnline: see SAUSA300_1264

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

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ATGACATTACTAACAAGAATAAAAACTGAAACTATATTACTTGAAAGCGACATTAAAGAG
CTAATCGATATACTTATTTCTCCTAGTATTGGAACTGATATTAAATATGAATTACTTAGT
TCCTATTCGGAGCGAGAAATCCAACAACAAGAATTAACATATATTGTACGTAGCTTAATT
AATACAATGTATCCACATCAACCATGTTATGAAGGGGCTATGTGTGTGTGCGGCACAGGT
GGTGACAAGTCAAATAGTTTCAACATTTCAACGACTGTTGCTTTTGTTGTAGCAAGTGCT
GGCGTAAAAGTTATAAAACATGGTAATAAAAGTATTACCTCAAATTCAGGTAGTACGGAT
TTGTTAAATCAAATGAACATACAAACAACAACTGTTGATGATACACCTAACCAATTAAAT
GAAAAAGACCTTGTATTCATTGGTGCAACTGAATCATATCCAATCATGAAGTATATGCAA
CCAGTTAGAAAAATGATTGGAAAGCCTACAATATTAAACCTTGTGGGTCCATTAATTAAT
CCATATCACTTAACGTATCAAATGGTAGGCGTCTTTGATCCTACAAAGTTAAAGTTAGTT
GCTAAAACGATTAAAGATTTAGGTAGAAAACGTGCAATCGTTTTACATGGTGCAAATGGT
ATGGATGAAGCAACACTATCTGGTGATAATTTGATATATGAATTGACTGAAGATGGAGAA
ATCAAAAATTACACATTAAATGCGACTGATTATGGTTTGAAACATGCGCCGAATAGTGAT
TTTAAAGGCGGTTCACCTGAAGAAAATTTAGCAATCTCCCTTAATATCTTGAATGGTAAA
GATCAGTCAAGTCGACGTGATGTTGTCTTACTAAATGCGGGTTTAAGCCTTTATGTTGCA
GAGAAAGTGGATACCATCGCAGAAGGCATAGAACTTGCAACTACATTGATTGATAATGGT
GAAGCATTGGAAAAATACCATCAAATGAGAGGTGAATAA
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⊟Protein[edit | edit source]

⊟General[edit | edit source]

locus tag: SAUSA300_RS06865 [old locus tag: SAUSA300_1264 ]
symbol: SAUSA300_RS06865
description: anthranilate phosphoribosyltransferase
length: 332
theoretical pI: 4.96694
theoretical MW: 36526.5
GRAVY: -0.193976

⊟Function[edit | edit source]

reaction:
EC 2.4.2.18? ExPASy
Anthranilate phosphoribosyltransferase N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
TIGRFAM:
Metabolism Amino acid biosynthesis Aromatic amino acid family anthranilate phosphoribosyltransferase (TIGR01245; EC 2.4.2.18; HMM-score: 293.8)
and 3 more
putative thymidine phosphorylase (TIGR02645; EC 2.4.2.4; HMM-score: 20.8)
AMP phosphorylase (TIGR03327; EC 2.4.-.-; HMM-score: 20.6)
Metabolism Purines, pyrimidines, nucleosides, and nucleotides Other pyrimidine-nucleoside phosphorylase (TIGR02644; EC 2.4.2.2; HMM-score: 18.3)
TheSEED: see SAUSA300_1264
PFAM:
no clan defined Glycos_transf_3; Glycosyl transferase family, a/b domain (PF00591; HMM-score: 265.5)

⊟Structure, modifications & cofactors[edit | edit source]

domains:
modifications:
cofactors: Mg²⁺
effectors:

⊟Localization[edit | edit source]

PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
LocateP:
SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.003672
- TAT(Tat/SPI): 0.00015
- LIPO(Sec/SPII): 0.000494
predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

GI: 446095977 NCBI
RefSeq: WP_000173832 NCBI
UniProt: see SAUSA300_1264

⊟Protein sequence[edit | edit source]

MTLLTRIKTETILLESDIKELIDILISPSIGTDIKYELLSSYSEREIQQQELTYIVRSLINTMYPHQPCYEGAMCVCGTGGDKSNSFNISTTVAFVVASAGVKVIKHGNKSITSNSGSTDLLNQMNIQTTTVDDTPNQLNEKDLVFIGATESYPIMKYMQPVRKMIGKPTILNLVGPLINPYHLTYQMVGVFDPTKLKLVAKTIKDLGRKRAIVLHGANGMDEATLSGDNLIYELTEDGEIKNYTLNATDYGLKHAPNSDFKGGSPEENLAISLNILNGKDQSSRRDVVLLNAGLSLYVAEKVDTIAEGIELATTLIDNGEALEKYHQMRGE

⊟Experimental data[edit | edit source]

experimentally validated: data available for COL, NCTC8325
protein localization: data available for COL
quantitative data / protein copy number per cell:
interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

regulator: T-box(Trp), CodY see SAUSA300_1264

⊟Transcription pattern[edit | edit source]

S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

Aureolib: no data available

⊟Protein stability[edit | edit source]

half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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