PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 02-MAR-2017

⊟Summary

• organism: Staphylococcus aureus USA300_FPR3757
• locus tag: SAUSA300_RS10470 [old locus tag: SAUSA300_1913 ]
• pan locus tag^?: SAUPAN004999000
• symbol: SAUSA300_RS10470
• pan gene symbol^?: pmtA
• synonym:
• product: ABC transporter ATP-binding protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SAUSA300_RS10470 [old locus tag: SAUSA300_1913 ]
• symbol: SAUSA300_RS10470
• product: ABC transporter ATP-binding protein
• replicon: chromosome
• strand: -
• coordinates: 2078181..2079077
• length: 897
• essential: unknown other strains

⊟Accession numbers

• Location: NC_007793 (2078181..2079077) NCBI
• BioCyc: SAUSA300_RS10470 BioCyc
• MicrobesOnline: see SAUSA300_1913

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  841
  
  ATGAATGCCATAGAATTAAGTAATGTTAATTATTCAAGTGATCAGTTTAATTTAAAGAAT
  ATCTCTTTCAAAGTTCCTCAAGGATTCGTCACTGGTTTTATTGGTAGAAATGGCGCTGGT
  AAAACCACAATAATAAGGTTAATTATGGATTTGTATCAACCACAAACTGGTGTTATTAGA
  GTATTAGAAGAGGATATGGCTCTCAATCCGATAGAGTTAAAGAATAGAATTGGGTTTGTT
  TACTCTGAAAATTATTTTAATGAGAGATGGACTACGAAGCAACTTGAAAAAATGATTGCC
  CCTTTTTATCGTAAATGGGACCATCAAGTATTTGAATTTTATCTTGAAAAGTTCGATTTA
  CCAATCAATAAATCAATAAAAACATTTTCGACTGGGATGAAAATGAAATTATCACTAGCA
  GTTGCATTTTCACATCATGCTGAATTGTATATTTTTGATGAGCCTACTTCAGGTCTTGAT
  CCCTTAGCTAGAAATGAGCTATTGGAGATAATTCAGCAAGAATTAATTGATGAAAATAAA
  ACAATATTCATGTCGACACACATTATCTCAGATTTAGAAAAAATAGCTGATTATATCATT
  CACTTAAGTGACGGTGAAGTTATCTTAAATGGTTCAAAAGAACAACTGTTACAAAGATAT
  CAAGTTGTGAGTGGTGCTATTGAGGACCTTGATGATGAATTAGCATCTCTACTTATTTAT
  GAAGAACATAAGCGTACGGGATTTATAGGATTAACAGAACATGCGCAAGTATTTAAAGAA
  ATTTTAGGTCATAAAGTGAATATCACTACACCTTCTATTGAGAACTTAATGGTTTATCTT
  GAAAAGAGAAAACCTAAATATCATGAAAACATCAAATTGATGGAAGAAGGTTTTTAA
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⊟Protein

⊟General

• locus tag: SAUSA300_RS10470 [old locus tag: SAUSA300_1913 ]
• symbol: SAUSA300_RS10470
• description: ABC transporter ATP-binding protein
• length: 298
• theoretical pI: 5.25888
• theoretical MW: 34520.4
• GRAVY: -0.242282

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 145)
  and 76 more
  gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 112.5)
  lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 109.5)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 106.1)
  Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 102.1)
  Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 102.1)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 100.7)
  Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 100.6)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 100.6)
  Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 95.7)
  Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 87.2)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 86.9)
  Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 86.9)
  Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 79.5)
  thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 78.2)
  Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 76.5)
  proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 75.9)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 75.5)
  Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 73.2)
  Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 71.7)
  ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 71.7)
  Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 71.6)
  Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 70.8)
  Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 67.6)
  Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 66.5)
  Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 65.9)
  Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 65.9)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 65.8)
  Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 65.8)
  Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 65.8)
  ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 65.3)
  Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 65.1)
  Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 65.1)
  Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 63.5)
  Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 62)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 61.3)
  Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 61.3)
  Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 61.2)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 60.6)
  Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 60)
  Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 60)
  Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 59.9)
  Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 59.9)
  Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 59.9)
  Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 59.8)
  D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 58.9)
  ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 58.6)
  Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 58.2)
  Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 58.2)
  Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 58.1)
  thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 57.2)
  ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 57)
  2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 56.5)
  Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 56.3)
  Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 56.1)
  Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 56.1)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 53.9)
  Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 52.9)
  Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 52.9)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 52.5)
  Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 51.9)
  phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 49.5)
  Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 44.4)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 43.9)
  Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 43.6)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 43)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 41.8)
  Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 40.6)
  Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 35.9)
  Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 27.7)
  Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 17.3)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 16.1)
  Genetic information processing DNA metabolism Other MutS2 family protein (TIGR01069; HMM-score: 15.4)
  Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 14.4)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA replication and repair protein RecF (TIGR00611; HMM-score: 12.8)
  Genetic information processing Protein fate Protein modification and repair hydrogenase maturation peptidase HycI (TIGR00142; EC 3.4.23.-; HMM-score: 12.7)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobalamin biosynthesis protein CobW (TIGR02475; HMM-score: 11.2)
• TheSEED: see SAUSA300_1913
• PFAM:
  P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 88.8)
  and 12 more
  AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 51.1)
  no clan defined DUF4941; Domain of unknown function (DUF4941) (PF16299; HMM-score: 18.7)
  P-loop_NTPase (CL0023) AAA_15; AAA ATPase domain (PF13175; HMM-score: 18.4)
  SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 18.2)
  AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.7)
  AAA_13; AAA domain (PF13166; HMM-score: 16)
  AAA_23; AAA domain (PF13476; HMM-score: 14.9)
  RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 13.7)
  PhoU (CL0297) PhoU; PhoU domain (PF01895; HMM-score: 13.2)
  P-loop_NTPase (CL0023) AAA_18; AAA domain (PF13238; HMM-score: 12.7)
  AAA_30; AAA domain (PF13604; HMM-score: 12.7)
  Zeta_toxin; Zeta toxin (PF06414; HMM-score: 12.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 1.05
  • Cytoplasmic Membrane Score: 8.78
  • Cellwall Score: 0.08
  • Extracellular Score: 0.09
  • Internal Helices: 0
• LocateP:
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.00282
  • TAT(Tat/SPI): 0.000259
  • LIPO(Sec/SPII): 0.000319
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 446914046 NCBI
• RefSeq: WP_000991302 NCBI
• UniProt: see SAUSA300_1913

⊟Protein sequence

• MNAIELSNVNYSSDQFNLKNISFKVPQGFVTGFIGRNGAGKTTIIRLIMDLYQPQTGVIRVLEEDMALNPIELKNRIGFVYSENYFNERWTTKQLEKMIAPFYRKWDHQVFEFYLEKFDLPINKSIKTFSTGMKMKLSLAVAFSHHAELYIFDEPTSGLDPLARNELLEIIQQELIDENKTIFMSTHIISDLEKIADYIIHLSDGEVILNGSKEQLLQRYQVVSGAIEDLDDELASLLIYEEHKRTGFIGLTEHAQVFKEILGHKVNITTPSIENLMVYLEKRKPKYHENIKLMEEGF

⊟Experimental data

• experimentally validated: data available for COL, NCTC8325
• protein localization: data available for COL
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator: PmtR* see SAUSA300_1913

⊟Transcription pattern

• S.aureus Expression Data Browser: data available for NCTC8325

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications