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NCBI: 02-MAR-2017

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS12160 [old locus tag: SA2115 ]
  • pan locus tag?: SAUPAN005805000
  • symbol: SA_RS12160
  • pan gene symbol?: glvR
  • synonym:
  • product: MurR/RpiR family transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS12160 [old locus tag: SA2115 ]
  • symbol: SA_RS12160
  • product: MurR/RpiR family transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 2378665..2379429
  • length: 765
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_002745 (2378665..2379429) NCBI
  • BioCyc: SA_RS12160 BioCyc
  • MicrobesOnline: see SA2115

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGTTTTTAGATGAACACATTAATCGAAACTTTGATAAACTTAATGATAATGATTTACAT
    ATCGCTCACTTTATCAATACACATATAGATGAATGTAAAAATATGAAAATACAAGATTTA
    GCGCAATTCACACATGCCTCGAATGCAACCATTCACAGATTTACACGCAAATTAGGTTTT
    GACGGTTATAGTGATTTTAAATCGTACCTTAAATTTGAAAGTAATAAGACACACCAATTA
    CCTTCTAACTCTATCGATAGTTTCAAACAAGAAATCGATAGTACATTCAGTTATTTAGAA
    CGCGTTGATTACCAGCTTCTTACTGAAAAAATGCATACAGCTTCAACAATATATTTGTAT
    GGTACAGGGCGTGCACAGTTAAACGTTGCTTCAGAGGCACAGCGTATATTGTTAACGTTA
    CATAATCATGTCATTGTACTTCATGATGAACATGAACTTAAAATGATTTTGAACAAGAGT
    GAACCTAATGATTTATTCTTTATTATTTCATTATCAGGTGAAACACATGAATTATTAGAA
    GTAACAAACTTGCTTCAACTTAGACAAAAATACTTTATTTCTGTTACTACAATGAAAGAT
    AATACCCTTGCTCAAAAAGCAAATTACAACGTCTATGTATCCAGTAACACATTCTACTTA
    ACTGATGGTACAGACTATTCTAGCTTCATCAGTTATCATATATTCTTTGAAACACTTGTA
    AGAAAATATAATGAGTATTTACTACATAATGATATTTCAAATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    765

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA_RS12160 [old locus tag: SA2115 ]
  • symbol: SA_RS12160
  • description: MurR/RpiR family transcriptional regulator
  • length: 254
  • theoretical pI: 6.33997
  • theoretical MW: 29785.2
  • GRAVY: -0.422047

⊟Function[edit | edit source]

  • TIGRFAM:
    6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 47.6)
    and 4 more
    Metabolism Energy metabolism Sugars sugar isomerase, KpsF/GutQ family (TIGR00393; HMM-score: 26.3)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 19.6)
    Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 19.6)
    bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 13.1)
  • TheSEED: see SA2115
  • PFAM:
    HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 64.3)
    SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 60.6)
    and 4 more
    SIS_2; SIS domain (PF13580; HMM-score: 14.8)
    HTH (CL0123) HTH_IclR; IclR helix-turn-helix domain (PF09339; HMM-score: 14.3)
    no clan defined DUF4065; Protein of unknown function (DUF4065) (PF13274; HMM-score: 13.2)
    HTH (CL0123) MarR; MarR family (PF01047; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by GlvR*, TF important in Maltose utilization: see SA2115

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004508
    • TAT(Tat/SPI): 0.000748
    • LIPO(Sec/SPII): 0.00093
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFLDEHINRNFDKLNDNDLHIAHFINTHIDECKNMKIQDLAQFTHASNATIHRFTRKLGFDGYSDFKSYLKFESNKTHQLPSNSIDSFKQEIDSTFSYLERVDYQLLTEKMHTASTIYLYGTGRAQLNVASEAQRILLTLHNHVIVLHDEHELKMILNKSEPNDLFFIISLSGETHELLEVTNLLQLRQKYFISVTTMKDNTLAQKANYNVYVSSNTFYLTDGTDYSSFISYHIFFETLVRKYNEYLLHNDISN

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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