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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA_RS12820 [old locus tag: SA2232 ]
  • pan locus tag?: SAUPAN005995000
  • symbol: SA_RS12820
  • pan gene symbol?:
  • synonym:
  • product: 2-dehydropantoate 2-reductase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SA_RS12820 [old locus tag: SA2232 ]
  • symbol: SA_RS12820
  • product: 2-dehydropantoate 2-reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 2506626..2507561
  • length: 936
  • essential: no DEG other strains

Accession numbers[edit | edit source]

  • Location: NC_002745 (2506626..2507561) NCBI
  • BioCyc: G1G21-2601 BioCyc
  • MicrobesOnline: see SA2232

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGAAAATTGCAATTGCTGGATCGGGTGCATTAGGTAGTGGCTTTGGTGCCAAACTATTT
    CAAGCAGGATATGATGTCACACTTATTGACGGATATACATCTCATGTTGAAGCGGTTAAG
    CAACATGGATTAAATATAACGATTAATGGAGAGGCATTCGAGTTAAACATTCCGATGTAT
    CATTTTAATGATCAACGGGACGAAAGCATTTACGATGTTGTCTTTCTATTTCCAAAGTCT
    ATGCAATTAAAAGAAGTGATGGAAGATATGAAGCCACATATTGATAATGAAACGATCGTC
    GTATGTACGATGAATGGTCTGAAGCATGAAGAAGTCATTGCGCAGTATGTTGCTCAATCA
    CAAATTGTCAGAGGTGTTACGACTTGGACGGCAGGTCTTGAAAGCCCTGGACACAGTCAT
    TTACTTGGTAGTGGACCAGTTGAAATAGGTGAACTAGTGGATGAAGGTAAAGAAAATGTT
    ATAAAAGTTGCTGATTTACTTAACGAAGCGGAATTGAATGGTGTCATTAGTAAAGATTTA
    TACCAATCGATTTGGAAAAAGATTTGTGTTAATGGTACGGCAAATGCATTAAGCACAGTG
    TTGGAGTGTAATATGGCATCACTGAATGAAAGTAGTTATGCGAAGTGTTTGATTTATAAA
    TTAACGCAAGAAATAGTGCATGTAGCGACGATTGATAATGTTCATTTAAATGTTGATGAA
    GCATTTGAATATTTAGTTGATTTAAATGAAAAAGTTGGTGCGCATTATCCATCCATGTAT
    CAAGATTTAATTGTTAATAATAGAAAAACTGAAATTGATTATATTAATGGCGCAGTTGCA
    ACATTGGGTAAACAACGTCATATTGAAGCGCCAGTCAATCGCTTTATTACTGATTTAATT
    CATACTAAAGAAAGTCAGCGACACGCACAGGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    936

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SA_RS12820 [old locus tag: SA2232 ]
  • symbol: SA_RS12820
  • description: 2-dehydropantoate 2-reductase
  • length: 311
  • theoretical pI: 4.87232
  • theoretical MW: 34474.9
  • GRAVY: -0.134405

Function[edit | edit source]

  • reaction:
    EC 1.1.1.169?  ExPASy
    2-dehydropantoate 2-reductase (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A 2-dehydropantoate 2-reductase (TIGR00745; EC 1.1.1.-; HMM-score: 304)
    and 4 more
    Cellular processes Cellular processes Toxin production and resistance tellurite resistance protein TehB (TIGR00477; HMM-score: 17.6)
    Metabolism Energy metabolism Electron transport NADPH-dependent F420 reductase (TIGR01915; HMM-score: 16)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 14.7)
    selenium-dependent molybdenum hydroxylase system protein, YqeB family (TIGR03309; HMM-score: 11.8)
  • TheSEED: see SA2232
  • PFAM:
    NADP_Rossmann (CL0063) ApbA; Ketopantoate reductase PanE/ApbA (PF02558; HMM-score: 131.1)
    6PGD_C (CL0106) ApbA_C; Ketopantoate reductase PanE/ApbA C terminal (PF08546; HMM-score: 112.3)
    and 9 more
    NADP_Rossmann (CL0063) NAD_Gly3P_dh_N; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus (PF01210; HMM-score: 25.1)
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 23.1)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 20.8)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 20)
    UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 16.8)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 15.8)
    no clan defined DUF4172; Domain of unknown function (DUF4172) (PF13776; HMM-score: 15.1)
    NADP_Rossmann (CL0063) TehB; Tellurite resistance protein TehB (PF03848; HMM-score: 14.4)
    FAD_binding_3; FAD binding domain (PF01494; HMM-score: 11.4)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.119015
    • TAT(Tat/SPI): 0.002171
    • LIPO(Sec/SPII): 0.03313
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MKIAIAGSGALGSGFGAKLFQAGYDVTLIDGYTSHVEAVKQHGLNITINGEAFELNIPMYHFNDQRDESIYDVVFLFPKSMQLKEVMEDMKPHIDNETIVVCTMNGLKHEEVIAQYVAQSQIVRGVTTWTAGLESPGHSHLLGSGPVEIGELVDEGKENVIKVADLLNEAELNGVISKDLYQSIWKKICVNGTANALSTVLECNMASLNESSYAKCLIYKLTQEIVHVATIDNVHLNVDEAFEYLVDLNEKVGAHYPSMYQDLIVNNRKTEIDYINGAVATLGKQRHIEAPVNRFITDLIHTKESQRHAQD

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]