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NCBI: 03-AUG-2016
⊟Summary[edit | edit source]
- organism: Staphylococcus aureus NCTC8325
- locus tag: SAOUHSC_01183
- pan locus tag?: SAUPAN003499000
- symbol: SAOUHSC_01183
- pan gene symbol?: fmt
- synonym:
- product: methionyl-tRNA formyltransferase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
⊟Accession numbers[edit | edit source]
- Gene ID: 3919316 NCBI
- RefSeq: YP_499722 NCBI
- BioCyc: G1I0R-1109 BioCyc
- MicrobesOnline: 1289636 MicrobesOnline
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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901ATGACTAAAATAATATTTATGGGTACACCAGACTTTTCAACAACTGTTTTAGAAATGCTT
ATTGCAGAACATGATGTCATTGCAGTCGTAACGCAACCAGATCGACCTGTTGGACGTAAA
CGTGTTATGACACCACCACCAGTTAAAAAAGTTGCAATGAAATATGATTTACCTGTATAT
CAACCTGAAAAATTAAGTGGATCAGAAGAATTAGAACAATTGCTTCAATTAGATGTAGAT
TTAATTGTAACTGCTGCTTTTGGACAATTATTACCTGAATCATTGTTGGCATTACCAAAT
CTTGGGGCAATTAATGTACATGCATCATTGTTACCGAAGTATAGAGGTGGTGCACCAATT
CATCAGGCAATTATCGATGGTGAACAAGAAACCGGCATAACAATTATGTATATGGTTAAA
AAATTAGATGCGGGTAATATTATTTCGCAACAAGCAATTAAAATAGAAGAAAATGATAAT
GTCGGTACGATGCATGATAAATTAAGTGTATTAGGGGCAGATTTATTAAAAGAAACTTTA
CCATCTATTATAGAGGGCACAAATGAAAGCGTACCTCAAGATGATACGCAAGCAACATTT
GCTTCCAATATTCGACGCGAAGATGAGCGAATTAGCTGGAATAAACCAGGAAGACAAGTG
TTTAATCAAATTCGTGGATTATCACCATGGCCAGTTGCTTATACAACTATGGATGACACT
AACTTGAAAATATACGATGCTGAACTCGTTGAGACTAATAAGATAAACGAGCCTGGAACC
ATTATAGAAACGACTAAAAAAGCCATTATTGTTGCTACAAATGATAATGAAGCTGTTGCA
ATTAAAGATATGCAATTAGCTGGGAAAAAGAGAATGTTAGCTGCCAATTATTTAAGTGGT
GCGCAAAACACACTAGTAGGGAAGAAACTTATATGA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SAOUHSC_01183
- symbol: SAOUHSC_01183
- description: methionyl-tRNA formyltransferase
- length: 311
- theoretical pI: 4.95985
- theoretical MW: 34211.3
- GRAVY: -0.160129
⊟Function[edit | edit source]
- ⊞reaction: EC 2.1.2.9? ExPASy
- ⊞TIGRFAM: Protein synthesis tRNA aminoacylation methionyl-tRNA formyltransferase (TIGR00460; EC 2.1.2.9; HMM-score: 355.3)and 2 more
- ⊞TheSEED :
- Methionyl-tRNA formyltransferase (EC 2.1.2.9)
Cofactors, Vitamins, Prosthetic Groups, Pigments Folate and pterines Folate Biosynthesis Methionyl-tRNA formyltransferase (EC 2.1.2.9)and 1 more - ⊞PFAM: no clan defined Formyl_trans_N; Formyl transferase (PF00551; HMM-score: 137.6)and 1 more
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MTKIIFMGTPDFSTTVLEMLIAEHDVIAVVTQPDRPVGRKRVMTPPPVKKVAMKYDLPVYQPEKLSGSEELEQLLQLDVDLIVTAAFGQLLPESLLALPNLGAINVHASLLPKYRGGAPIHQAIIDGEQETGITIMYMVKKLDAGNIISQQAIKIEENDNVGTMHDKLSVLGADLLKETLPSIIEGTNESVPQDDTQATFASNIRREDERISWNKPGRQVFNQIRGLSPWPVAYTTMDDTNLKIYDAELVETNKINEPGTIIETTKKAIIVATNDNEAVAIKDMQLAGKKRMLAANYLSGAQNTLVGKKLI
⊟Experimental data[edit | edit source]
- experimentally validated: PeptideAtlas [2] [3]
- protein localization: data available for COL
- quantitative data / protein copy number per cell: data available for COL
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SAOUHSC_01182 > SAOUHSC_01183 > SAOUHSC_01184 > SAOUHSC_01185 > SAOUHSC_01186 > SAOUHSC_01187predicted SigA promoter [4] : SAOUHSC_01182 > SAOUHSC_01183 > SAOUHSC_01184 > SAOUHSC_01185 > SAOUHSC_01186 > SAOUHSC_01187
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription pattern[edit | edit source]
- S.aureus Expression Data Browser: [4] ⊟Multi-gene expression profiles
⊟Protein synthesis (provided by Aureolib)[edit | edit source]
- Aureolib: no data available
⊟Protein stability[edit | edit source]
- half-life: no data available
⊞Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊞Other Information[edit | edit source]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Roy R Chaudhuri, Andrew G Allen, Paul J Owen, Gil Shalom, Karl Stone, Marcus Harrison, Timothy A Burgis, Michael Lockyer, Jorge Garcia-Lara, Simon J Foster, Stephen J Pleasance, Sarah E Peters, Duncan J Maskell, Ian G Charles
Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH).
BMC Genomics: 2009, 10;291
[PubMed:19570206] [WorldCat.org] [DOI] (I e) - ↑ Maren Depke, Stephan Michalik, Alexander Rabe, Kristin Surmann, Lars Brinkmann, Nico Jehmlich, Jörg Bernhardt, Michael Hecker, Bernd Wollscheid, Zhi Sun, Robert L Moritz, Uwe Völker, Frank Schmidt
A peptide resource for the analysis of Staphylococcus aureus in host-pathogen interaction studies.
Proteomics: 2015, 15(21);3648-61
[PubMed:26224020] [WorldCat.org] [DOI] (I p) - ↑ Stephan Michalik, Maren Depke, Annette Murr, Manuela Gesell Salazar, Ulrike Kusebauch, Zhi Sun, Tanja C Meyer, Kristin Surmann, Henrike Pförtner, Petra Hildebrandt, Stefan Weiss, Laura Marcela Palma Medina, Melanie Gutjahr, Elke Hammer, Dörte Becher, Thomas Pribyl, Sven Hammerschmidt, Eric W Deutsch, Samuel L Bader, Michael Hecker, Robert L Moritz, Ulrike Mäder, Uwe Völker, Frank Schmidt
A global Staphylococcus aureus proteome resource applied to the in vivo characterization of host-pathogen interactions.
Sci Rep: 2017, 7(1);9718
[PubMed:28887440] [WorldCat.org] [DOI] (I e) - ↑ Jump up to: 4.0 4.1 Ulrike Mäder, Pierre Nicolas, Maren Depke, Jan Pané-Farré, Michel Debarbouille, Magdalena M van der Kooi-Pol, Cyprien Guérin, Sandra Dérozier, Aurelia Hiron, Hanne Jarmer, Aurélie Leduc, Stephan Michalik, Ewoud Reilman, Marc Schaffer, Frank Schmidt, Philippe Bessières, Philippe Noirot, Michael Hecker, Tarek Msadek, Uwe Völker, Jan Maarten van Dijl
Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions.
PLoS Genet: 2016, 12(4);e1005962
[PubMed:27035918] [WorldCat.org] [DOI] (I e)