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NCBI: 26-AUG-2013

Summary[edit source | edit]

  • organism: Staphylococcus aureus N315
  • locus tag: SA2304 [new locus tag: SA_RS13210 ]
  • pan locus tag?: SAUPAN006159000
  • symbol: fbp
  • pan gene symbol?: fbp
  • synonym:
  • product: fructose-bisphosphatase

Genome View[edit source | edit]

Gene[edit source | edit]

General[edit source | edit]

  • type: CDS
  • locus tag: SA2304 [new locus tag: SA_RS13210 ]
  • symbol: fbp
  • product: fructose-bisphosphatase
  • replicon: chromosome
  • strand: +
  • coordinates: 2588859..2590823
  • length: 1965
  • essential: no DEG other strains

Accession numbers[edit source | edit]

Phenotype[edit source | edit]

  • Share your knowledge and add information here. [edit]

DNA sequence[edit source | edit]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGACTCAAATTACTGAAAAAGAATTAAAAAAGAAGTATTTAGATTTACTATCCCAAAAT
    TTTGATACTCCAGAAAAACTTGCAACTGAAATTATCAATTTAGAATCAATTTTAGAATTA
    CCTAAAGGTACGGAACATTTCGTCAGCGATTTACATGGTGAATACGAAGCTTTCCAACAC
    GTATTACGCAACGGTTCTGGGAATGTGCGAGCGAAAATCAATGATATTTTCAAAGAGAGA
    CTTTCAACTAAGGAGCTTAATGATTTAACTGCTCTTGTCTACTATCCAGAAGACAAATTA
    AAATTGATTAAAAGTGATTTCCAAAGTTGCGGTCAACTTAATGTCTGGTATATCACAACA
    ATCGAACATTTAATTGAGTTGATTAAATATTGTTCTTCAAAATATACGCGTTCAAAACTG
    CGTAAAGCATTGCCAAAACAATACGTTTATATTATTGAGGAACTACTGTATAAAAGTAAT
    GAATATCAAAATAAAAAATCATATTACGAAACACTTGTTAACCAAGTAATTGAACTTAAA
    CAGGCAGATGATTTAATTATTGGACTCGCTTATTCCGTACAACGCTTAGTCGTCGATCAT
    TTACACGTTGTCGGTGATATTTATGATCGTGGACCACAACCAGATAAAATTATGGATACA
    CTGATTAATTATCATTCCCTAGATATTCAATGGGGTAATCATGATGTGCTTTGGGTTGGA
    GCCTATGCTGGGTCAAAAGTATGCTTAGCAAACTTACTTCGAATTTGTGCACGCTATGAT
    AATTTAGATATTATCGAAGACGCTTATGGCATTAATTTAAGACCACTGCTTACTTTAGCT
    GAAAAATACTATGACGCAGATAATCCTGCTTTTAAGCCTAAAAAAAGACCTGACAAACAC
    GAACGTTTAACTCAACGTGAAGAAAGTCAAATTACTAAAATTCATCAAGCTATTGCGATG
    ATTCAATTCAAGTTAGAAATACCAATTATTAAACGTCGTCCAAATTTCGAAATGGAAGAA
    CGTCTTGTGCTTGAAAAGGTTAATTATGATACAAATGAAATTACAGTTTATGGTAATACA
    TACCCGTTGAAAGACACATGTTTCCAAACTATCAATCGTAATAATCCAGCAGAATTACTA
    CCTGAAGAAGAAGAAGTCATGAATAAACTATTATTGTCATTCCAACAATCTGAAAAATTA
    CGTCGTCATATGTCTTTCTTGATGCGTAAAGGTTCGCTTTACTTACCATATAATGGTAAT
    TTACTCATTCATGGTTGTATTCCAGTTGATGAAAATGGTGAGATGGAATCATTTGAAATT
    GATGGTCATACTTACAGCGGCCAAGAATTATTAGATGTGTTTGAGTATCATGTCCGTAAA
    TCATTTGATGAAAAAGAAAATACTGATGACTTATCGACGGATTTAGTTTGGTATTTATGG
    ACTGGGAAATATTCGTCATTATTTGGTAAACGCGCGATGACTACGTTTGAGCGATATTTT
    ATTGCAGATAAAGCTTCTCATAAAGAAGAAAAAAATCCATACTATCATTTACGTGAAGAT
    GTGAATATGGTTCGTAAAATGCTCAGTGATTTCGGATTAAATCCAGATGAAGGACGCATT
    ATTAATGGTCACACACCAGTGAAAGAAATCAATGGCGAAGATCCTATCAAGGCTGATGGA
    AAGATGCTTGTCATTGATGGTGGTTTTTCAAAAGCTTATCAGTCAACAACTGGCATTGCA
    GGCTATACATTGTTGTATAATTCATTCGGAATGCAACTCGTTGCACACCAACAATTTAAC
    GCTAAAGAAAAAATACTTTCCGAAGGTATCGATGAACTTTCTATAAAGCGCGTTGTAGAC
    AAAGAATTACAACGTAAGAAGATTCGTGATACCAATATTGGTAAAGAGCTTCAAGCTCAA
    ATAGATATTTTGAAAATGTTAATGCATGATCGTTACTTAGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1965

Protein[edit source | edit]

General[edit source | edit]

  • locus tag: SA2304 [new locus tag: SA_RS13210 ]
  • symbol: Fbp
  • description: fructose-bisphosphatase
  • length: 654
  • theoretical pI: 6.13565
  • theoretical MW: 76174.5
  • GRAVY: -0.515749

Function[edit source | edit]

  • reaction:
    EC 3.1.3.11?  ExPASy
    Fructose-bisphosphataseD-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate
  • TIGRFAM:
  • TheSEED:  
    CarbohydratesCentral carbohydrate metabolismGlycolysis and Gluconeogenesis Fructose-1,6-bisphosphatase, Bacillus type (EC 3.1.3.11) 
  • PFAM:
    Calcineurin (CL0163) FBPase_2; Firmicute fructose-1,6-bisphosphatase (PF06874; HMM-score: 941.1)
    no clan definedGP24_25; Tail assembly protein Gp24 and Gp25 (PF17388; HMM-score: 14.6)

Structure, modifications & interactions[edit source | edit]

  • domains:
  • modifications:
  • cofactors: Mn2+
  • effectors:
  • protein partners:

Localization[edit source | edit]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular Possibility: 1
    • Signal Peptide Possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • Ymax: 0.135
    • Ymax_pos: 11
    • Cmax: 0.115
    • Cmax_pos: 48
    • Smax: 0.295
    • Smax_pos: 2
    • Smean: 0.166
    • D: 0.147
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit source | edit]

Protein sequence[edit source | edit]

  • MTQITEKELKKKYLDLLSQNFDTPEKLATEIINLESILELPKGTEHFVSDLHGEYEAFQHVLRNGSGNVRAKINDIFKERLSTKELNDLTALVYYPEDKLKLIKSDFQSCGQLNVWYITTIEHLIELIKYCSSKYTRSKLRKALPKQYVYIIEELLYKSNEYQNKKSYYETLVNQVIELKQADDLIIGLAYSVQRLVVDHLHVVGDIYDRGPQPDKIMDTLINYHSLDIQWGNHDVLWVGAYAGSKVCLANLLRICARYDNLDIIEDAYGINLRPLLTLAEKYYDADNPAFKPKKRPDKHERLTQREESQITKIHQAIAMIQFKLEIPIIKRRPNFEMEERLVLEKVNYDTNEITVYGNTYPLKDTCFQTINRNNPAELLPEEEEVMNKLLLSFQQSEKLRRHMSFLMRKGSLYLPYNGNLLIHGCIPVDENGEMESFEIDGHTYSGQELLDVFEYHVRKSFDEKENTDDLSTDLVWYLWTGKYSSLFGKRAMTTFERYFIADKASHKEEKNPYYHLREDVNMVRKMLSDFGLNPDEGRIINGHTPVKEINGEDPIKADGKMLVIDGGFSKAYQSTTGIAGYTLLYNSFGMQLVAHQQFNAKEKILSEGIDELSIKRVVDKELQRKKIRDTNIGKELQAQIDILKMLMHDRYLD

Experimental data[edit source | edit]

  • experimentally validated: no data available

Expression & Regulation[edit source | edit]

Operon[edit source | edit]

Regulation[edit source | edit]

  • sigma factor:
  • regulator: CcpA
    CcpA (TF) important in Carbon catabolism  RegPrecise

Transcription pattern[edit source | edit]

Protein synthesis (provided by Aureolib)[edit source | edit]

Protein stability[edit source | edit]

  • half-life: no data available

Biological Material[edit source | edit]

Mutants[edit source | edit]

Expression vector[edit source | edit]

lacZ fusion[edit source | edit]

GFP fusion[edit source | edit]

two-hybrid system[edit source | edit]

FLAG-tag construct[edit source | edit]

Antibody[edit source | edit]

Other Information[edit source | edit]

You are kindly invited to share additional interesting facts.

Literature[edit source | edit]

References[edit source | edit]

Relevant publications[edit source | edit]