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Summary[edit source | edit]

  • pan ID?: SAUPAN003548000
  • symbol?: topA
  • description?: DNA topoisomerase I

      descriptions from strain specific annotations:

    • DNA topoisomerase I
    • DNA topoisomerase TopA
  • strand?: +
  • coordinates?: 3882965..3885040
  • synteny block?: BlockID0026250
  • occurrence?: in 100% of 32 strains

Orthologs[edit source | edit]

    COL:
    SACOL1267 (topA)
    N315:
    NCTC8325:
    Newman:
    NWMN_1160 (topA)
    USA300_FPR3757:
    04-02981:
    SA2981_1208 (topA)
    08BA02176:
    C248_1281 (topA)
    11819-97:
    MS7_1208 (topA)
    71193:
    ST398NM01_1252
    ECT-R 2:
    ECTR2_1106 (topA)
    ED133:
    SAOV_1252 (topA)
    ED98:
    SAAV_1224 (topA)
    HO 5096 0412:
    SAEMRSA15_10830 (topA)
    JH1:
    SaurJH1_1335
    JH9:
    SaurJH9_1310
    JKD6008:
    SAA6008_01205 (topA)
    JKD6159:
    SAA6159_01105 (topA)
    LGA251:
    SARLGA251_11610 (topA)
    M013:
    M013TW_1190
    MRSA252:
    SAR1226 (topA)
    MSHR1132:
    SAMSHR1132_10930
    MSSA476:
    SAS1184
    Mu3:
    SAHV_1240
    Mu50:
    SAV1250
    MW2:
    MW1133
    RF122:
    SAB1112 (topA)
    ST398:
    SAPIG1252 (topA)
    T0131:
    SAT0131_01301
    TCH60:
    HMPREF0772_11980 (topA)
    TW20:
    SATW20_12440 (topA)
    USA300_TCH1516:
    USA300HOU_1181 (topA)
    VC40:
    SAVC_05415

Genome Viewer[edit source | edit]

COL chromosome
N315 chromosome
NCTC8325 chromosome
Newman chromosome
USA300_FPR3757 chromosome

Alignments[edit source | edit]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.205)


    COL             --MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIR
    N315            --MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIR
    NCTC8325        MTLADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIR
    Newman          MTLADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIR
    USA300_FPR3757  MTLADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIR
                      :*********************************************************

    COL             GKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAV
    N315            GKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAV
    NCTC8325        GKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAV
    Newman          GKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAV
    USA300_FPR3757  GKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAV
                    ************************************************************

    COL             KESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDR
    N315            KESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDR
    NCTC8325        KESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDR
    Newman          KESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDR
    USA300_FPR3757  KESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDR
                    ************************************************************

    COL             ENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEI
    N315            ENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEI
    NCTC8325        ENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEI
    Newman          ENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEI
    USA300_FPR3757  ENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEI
                    ************************************************************

    COL             TNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITY
    N315            TNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITY
    NCTC8325        TNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITY
    Newman          TNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITY
    USA300_FPR3757  TNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITY
                    ************************************************************

    COL             MRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMK
    N315            MRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMK
    NCTC8325        MRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMK
    Newman          MRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMK
    USA300_FPR3757  MRTDSTRISDTAKVEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMK
                    *************.**********************************************

    COL             SFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVE
    N315            SFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVE
    NCTC8325        SFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVE
    Newman          SFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVE
    USA300_FPR3757  SFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVE
                    ************************************************************

    COL             TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY
    N315            TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY
    NCTC8325        TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY
    Newman          TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY
    USA300_FPR3757  TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY
                    ************************************************************

    COL             APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD
    N315            APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD
    NCTC8325        APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD
    Newman          APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD
    USA300_FPR3757  APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD
                    ************************************************************

    COL             ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACS
    N315            ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACS
    NCTC8325        ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACS
    Newman          ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACS
    USA300_FPR3757  ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACS
                    ****************************************:*******************

    COL             NFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDC
    N315            NFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDC
    NCTC8325        NFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDC
    Newman          NFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDC
    USA300_FPR3757  NFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDC
                    ************************************************************

    COL             PKCNQYLVENKKGKTTQVICSNCDYKEAAQK
    N315            PKCNQYLVENKKGKTTQVICSNCDYKEAAQK
    NCTC8325        PKCNQYLVENKKGKTTQVICSNCDYKEAAQK
    Newman          PKCNQYLVENKKGKTTQVICSNCDYKEAAQK
    USA300_FPR3757  PKCNQYLVENKKGKTTQVICSNCDYKEAAQK
                    *******************************