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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000519
  • pan locus tag?: SAUPAN002335000
  • symbol: sdrC
  • pan gene symbol?: sdrC
  • synonym:
  • product: MSCRAMM family adhesin SdrC

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000519
  • symbol: sdrC
  • product: MSCRAMM family adhesin SdrC
  • replicon: chromosome
  • strand: +
  • coordinates: 553254..556133
  • length: 2880
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    ATGAATAATAAAAAGACAGCAACAAATAGAAAAGGCATGATACCAAATCGATTAAACAAA
    TTTTCGATAAGAAAGTATTCTGTAGGTACTGCTTCAATTTTAGTAGGGACAACATTGATT
    TTTGGGTTAAGTGGTCATGAAGCTAAAGCGGCAGAACATACGAATGGAGAATTAAATCAA
    TCAAAAAATGAAACGACAGCCCCAAGTGAGAATAAAACAACTGAAAAAGTTGATAGTCGT
    CAACTAAAAGACAATACGCAAACTGCAACTGCAGATCAGCCTAAAGTGACAATGAGTGAT
    AGTGCAACAGTTAAAGAAACTAGTAGTAACATGCAATCACCACAAAACGCTACAGCTAGT
    CAATCTACTACACAAACTAGCAATGTAACAACAAATGATAAATCATCAACTACATATAGT
    AATGAAACTGATAAAAGTAATTTAACACAAGCAAAAAACGTTTCAACTACACCTAAAACA
    ACGACTATTAAACCAAGAACATTAAACCGTATGGCTGTGAACACAGTAGCAGCACCACAA
    CAAGGTACAAATGTTAATGATAAAGTTCATTTTTCAAATATTGATATTGCTATTGATAAA
    GGACATGTAAATTCAACAACTGGCAAAACTGAATTTTGGGCGACTTCTAGTGATGTTTTA
    AAATTAAAAGCGAATTACAAAATCGATGATTCTGTTAAAGAGGGCGATACATTTACATTT
    AAATATGGACAGTATTTCCGTCCGGGTTCTGTAAGATTACCTTCACAAACTCAAAATTTA
    TATAATGCCCAAGGTAATATTATTGCAAAAGGTATTTATGATAGTACAACAAACACAACA
    ACATATACTTTTACGAACTATGTGGATCAATATACAAATGTTAGCGGTAGCTTTGAACAA
    GTTGCATTTGCGAAACGTGAAAATGCAACAACTGATAAAACAGCTTATAAAATGGAAGTA
    ACTTTAGGTAATGATACATATAGCGAAGAAGTCATCGTCGATTATGGTAATAAAAAAGCA
    CAACCGCTTATTTCAAGTACAAACTATATCAATAATGAAGATTTATCACGAAATATGACT
    GTTTATGTAAATCAACCTAAAAATACATATACAAAAGAAACATTAGTAACAAATTTAACT
    GGTTATAAATTTAATCCAGATGCTAAAAACTTTAAAATTTATGAAGTAACTAACCAAAAT
    CAGTTTGTGGATAGTTTCACCCCAGATACTTCAAAACTTACAGATGTCACTGATAAATTT
    AAAATTACATACAGTAATGATAATAAGACGGCGACAGTTGATTTATTGAATGGTCAATCT
    AGTAGTGATAAACAGTACATCATTCAACAAGTTGCTTATCCAGATAATAGTTCAACAGAT
    AATGGGAAAATTGATTATACTTTAGAAACACAAAATGGAAAAAGTAGTTGGTCAAACAGT
    TATTCAAATGTGAATGGTTCATCAACTGCAAATGGCGACCAAAAGAAATATAATCTAGGT
    GACTATGTATGGGAAGATACAAATAAAGATGGTAAACAAGATGCCAATGAAAAAGGGATT
    AAAGGTGTTTATGTCATTCTTAAAGATAGTAACGGTAAAGAATTAGATCGTACGACAACA
    GATGAAAATGGTAAATATCAGTTCACTGGTTTAAGCAATGGAACTTATAGTGTAGAGTTT
    TCAACACCAGCCGGTTATACACCGACAACTGCAAATGCAGGAACTGATGATGCTGTTGAT
    TCAGATGGTTTAACAACAACAGGTGTCATTAAAGACGCTGACAACATGACATTAGATAGT
    GGATTCTATAAAACACCAAAATATAGTTTAGGTGATTATGTTTGGTACGACAGTAATAAA
    GATGGTAAACAAGATTCGACTGAAAAAGGAATTAAAGGTGTTAAAGTTACTTTGCAAAAC
    GAAAAAGGCGAAGTAATTGGTACAACTGAAACAGATGAAAATGGTAAATATCGTTTCGAT
    AATTTAGATAGCGGTAAATACAAAGTTATTTTTGAAAAGCCTGCTGGTTTAACTCAAACA
    GGTACAAATACAACTGAAGATGATAAAGATGCCGATGGTGGCGAAGTCGATGTAACAATT
    ACGGATCATGATGATTTCACACTTGATAATGGCTACTACGAAGAAGAAACATCAGATAGC
    GACTCAGATTCAGACAGCGATTCAGACTCAGATAGCGACTCAGATTCTGACAGCGATTCA
    GACTCAGATAGCGACTCAGATTCAGACAGCGACTCAGACTCAGATAGCGATTCAGATTCA
    GACAGCGACTCAGATTCAGACAGCGATTCAGATTCAGACAGCGACTCAGATTCAGATAGC
    GACTCAGACTCAGACAGCGATTCAGACTCAGATAGCGACTCAGATTCAGACAGCGACTCA
    GACTCAGACAGCGACTCAGACTCAGACAGTGATTCAGATTCAGATAGCGACTCAGATTCA
    GACAGCGACTCAGACTCAGACAGCGATTCAGACTCAGATAGCGACTCAGATTCAGACAGC
    GACTCAGACTCAGATAGCGACTCAGACTCAGACAGAGATTCAGATTCAGATAGCGACTCA
    GACTCAGATAGCGACTCAGACTCGGATAGCGATTCAGATTCAGACAGCGACTCAGATTCA
    GATAGCGATTCGGACTCAGACAACGACTCAGATTCAGATAGCGATTCAGATTCAGATGCA
    GGTAAACATACTCCGGCTAAACCAATGAGTACGGTTAAAGATCAGCATAAAACAGCTAAA
    GCATTACCAGAAACAGGTAGTGAAAATAATAATTCAAATAATGGCACATTATTCGGTGGA
    TTATTCGCGGCATTAGGATCATTATTGTTATTCGGTCGTCGTAAAAAACAAAATAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000519
  • symbol: SdrC
  • description: MSCRAMM family adhesin SdrC
  • length: 959
  • theoretical pI: 3.95047
  • theoretical MW: 103877
  • GRAVY: -1.16131

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 51.7)
    and 2 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 18.4)
    Metabolism Energy metabolism Other protocatechuate 3,4-dioxygenase, beta subunit (TIGR02422; EC 1.13.11.3; HMM-score: 15.3)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Transthyretin (CL0287) SdrD_B; SdrD B-like domain (PF17210; HMM-score: 214.8)
    and 20 more
    Adhesin (CL0204) SdrG_C_C; C-terminus of bacterial fibrinogen-binding adhesin (PF10425; HMM-score: 115.1)
    E-set (CL0159) Big_8; Bacterial Ig domain (PF17961; HMM-score: 83.7)
    Transthyretin (CL0287) CarboxypepD_reg; Carboxypeptidase regulatory-like domain (PF13620; HMM-score: 69.2)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 47)
    Transthyretin (CL0287) SpaA; Prealbumin-like fold domain (PF17802; HMM-score: 44.5)
    E-set (CL0159) bMG3; Bacterial alpha-2-macroglobulin MG3 domain (PF11974; HMM-score: 42.6)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 40.5)
    Transthyretin (CL0287) MetallophosN; N terminal of Calcineurin-like phosphoesterase (PF16371; HMM-score: 35.2)
    CarbopepD_reg_2; CarboxypepD_reg-like domain (PF13715; HMM-score: 29.6)
    Ig_DR_A0283-like; DR_A0283-like, Ig-like domain (PF24025; HMM-score: 26.6)
    NOMO1-like_9th; BOS complex subunit NOMO1-like, beta sandwich domain (PF22902; HMM-score: 22.2)
    E-set (CL0159) Ig_J; Tip attachment protein J, Ig-like domain (PF24421; HMM-score: 21.2)
    Transthyretin (CL0287) NOMO1-like_1st; BOS complex subunit NOMO1-like, first beta sandwich domain (PF22898; HMM-score: 19.7)
    DUF1416; Protein of unknown function (DUF1416) (PF07210; HMM-score: 16.9)
    DUF2606; Protein of unknown function (DUF2606) (PF10794; HMM-score: 16.1)
    Dioxygenase_C; Dioxygenase (PF00775; HMM-score: 14.6)
    TTR-52; Transthyretin-like family (PF01060; HMM-score: 13.7)
    DUF6795; Domain of unknown function (DUF6795) (PF20598; HMM-score: 13.1)
    E-set (CL0159) Big_6; Bacterial Ig domain (PF17936; HMM-score: 12.5)
    Transthyretin (CL0287) NOMO_3rd; NOMO third transthyretin-like domain (PF23193; HMM-score: 11.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0005
    • Cytoplasmic Membrane Score: 0.0163
    • Cell wall & surface Score: 0.9572
    • Extracellular Score: 0.026
  • LocateP:
  • SignalP: Signal peptide SP(Sec/SPI) length 50 aa
    • SP(Sec/SPI): 0.875151
    • TAT(Tat/SPI): 0.090427
    • LIPO(Sec/SPII): 0.001955
    • Cleavage Site: CS pos: 50-51. AKA-AE. Pr: 0.9392
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNNKKTATNRKGMIPNRLNKFSIRKYSVGTASILVGTTLIFGLSGHEAKAAEHTNGELNQSKNETTAPSENKTTEKVDSRQLKDNTQTATADQPKVTMSDSATVKETSSNMQSPQNATASQSTTQTSNVTTNDKSSTTYSNETDKSNLTQAKNVSTTPKTTTIKPRTLNRMAVNTVAAPQQGTNVNDKVHFSNIDIAIDKGHVNSTTGKTEFWATSSDVLKLKANYKIDDSVKEGDTFTFKYGQYFRPGSVRLPSQTQNLYNAQGNIIAKGIYDSTTNTTTYTFTNYVDQYTNVSGSFEQVAFAKRENATTDKTAYKMEVTLGNDTYSEEVIVDYGNKKAQPLISSTNYINNEDLSRNMTVYVNQPKNTYTKETLVTNLTGYKFNPDAKNFKIYEVTNQNQFVDSFTPDTSKLTDVTDKFKITYSNDNKTATVDLLNGQSSSDKQYIIQQVAYPDNSSTDNGKIDYTLETQNGKSSWSNSYSNVNGSSTANGDQKKYNLGDYVWEDTNKDGKQDANEKGIKGVYVILKDSNGKELDRTTTDENGKYQFTGLSNGTYSVEFSTPAGYTPTTANAGTDDAVDSDGLTTTGVIKDADNMTLDSGFYKTPKYSLGDYVWYDSNKDGKQDSTEKGIKGVKVTLQNEKGEVIGTTETDENGKYRFDNLDSGKYKVIFEKPAGLTQTGTNTTEDDKDADGGEVDVTITDHDDFTLDNGYYEEETSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDRDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDSDAGKHTPAKPMSTVKDQHKTAKALPETGSENNNSNNGTLFGGLFAALGSLLLFGRRKKQNK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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