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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_000692
  • pan locus tag?: SAUPAN002611000
  • symbol: hisC
  • pan gene symbol?: hisC
  • synonym:
  • product: histidinol-phosphate transaminase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_000692
  • symbol: hisC
  • product: histidinol-phosphate transaminase
  • replicon: chromosome
  • strand: +
  • coordinates: 727606..728664
  • length: 1059
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAAAGAACAACTTAATCAACTATCAGCATATCAGCCTGGTTTATCTCCAAGGGCATTG
    AAAGAAAAGTATGGCATTGAAGGAGATTTATATAAACTTGCATCAAATGAAAATTTGTAT
    GGACCATCGCCAAAAGTTAAAGAAGCGATATCAGCACACTTAGATGAGTTATATTATTAT
    CCTGAAACAGGATCACCGACATTAAAAGCGGCGATTAGTAAACATTTAAATGTAGATCAA
    TTACGCATTTTATTTGGTGCGGGATTAGATGAAGTTATATTAATGATTTCTAGAGCTGTA
    TTAACGCCAGGGGATACTATTGTTACAAGTGAAGCGACATTCGGTCAATATTATCACAAT
    GCGATTGTTGAATCAGCTAATGTGATACAAGTACCTTTAAAAGATGGTGGCTTCGATTTA
    GAAGGTATTTTAAAAGAAGTTAATGAAGATACGTCATTGGTATGGTTATGTAATCCAAAT
    AATCCTACAGGTACATATTTTAATCATGAGAGCTTAGATTCGTTTTTATCTCAAGTACCT
    CCACATGTACCAGTAATTATAGATGAAGCTTATTTTGAATTTGTGACAGCAGAGGACTAC
    CCAGATACACTTGCTTTGCAACAAAAATATGACAATGCTTTCTTATTACGTACATTTTCA
    AAGGCGTATGGATTAGCGGGCTTACGTGTAGGATATGTGGTAGCAAGTGAACATGCGATT
    GAAAAATGGAACATCATTAGACCACCATTTAATGTGACACGTATATCTGAATACGCAGCA
    GTTGCAGCACTTGAAGATCAACAATATTTAAAAGAGGTAGTACATAAAAATAGTGTTGAA
    CGCGAAAGATTTTATCAATTACCTCAAAGTGAGCATTTCTTGCCAAGTCAAACGAATTTT
    ATATTTGTAAAAACAAAGCGGGTAAATGAACTTTATGAAGCACTTTTAAATGTAGGGTGT
    ATTACGCGACCATTTCCAACTGGTGTTAGAATTACAATTGGTTTTAAAGAACAAAATGAT
    AAAATGTTAGAAGTTTTATCAAACTTTAAATACGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1059

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_000692
  • symbol: HisC
  • description: histidinol-phosphate transaminase
  • length: 352
  • theoretical pI: 4.92816
  • theoretical MW: 39785.8
  • GRAVY: -0.236648

⊟Function[edit | edit source]

  • reaction:
    EC 2.6.1.9?  ExPASy
    Histidinol-phosphate transaminase L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 305.5)
    and 15 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 180.1)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 75.9)
    beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 61.2)
    LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 60.1)
    succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 57.4)
    succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 56.2)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 51.1)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 50.2)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 48.4)
    succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 43.6)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 36.5)
    enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 24.4)
    enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 20.7)
    Metabolism Energy metabolism Amino acids and amines aspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 19.9)
    cystathionine beta-lyase (TIGR01329; EC 4.4.1.8; HMM-score: 18)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 182.4)
    and 4 more
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 20)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 17.2)
    Asp_aminotransf; Aspartate amino-transferase (PF12897; HMM-score: 17.2)
    Alliinase_C; Allinase (PF04864; HMM-score: 13.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9969
    • Cytoplasmic Membrane Score: 0.0007
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0021
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.01701
    • TAT(Tat/SPI): 0.001827
    • LIPO(Sec/SPII): 0.001818
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKEQLNQLSAYQPGLSPRALKEKYGIEGDLYKLASNENLYGPSPKVKEAISAHLDELYYYPETGSPTLKAAISKHLNVDQLRILFGAGLDEVILMISRAVLTPGDTIVTSEATFGQYYHNAIVESANVIQVPLKDGGFDLEGILKEVNEDTSLVWLCNPNNPTGTYFNHESLDSFLSQVPPHVPVIIDEAYFEFVTAEDYPDTLALQQKYDNAFLLRTFSKAYGLAGLRVGYVVASEHAIEKWNIIRPPFNVTRISEYAAVAALEDQQYLKEVVHKNSVERERFYQLPQSEHFLPSQTNFIFVKTKRVNELYEALLNVGCITRPFPTGVRITIGFKEQNDKMLEVLSNFKYE

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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