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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002479
  • pan locus tag?: SAUPAN006097000
  • symbol: fnbB
  • pan gene symbol?: fnbB
  • synonym:
  • product: fibronectin-binding protein FnbB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002479
  • symbol: fnbB
  • product: fibronectin-binding protein FnbB
  • replicon: chromosome
  • strand: -
  • coordinates: 2480050..2482800
  • length: 2751
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    GTGAAAAGCAATCTTAGATACGGCATAAGAAAACACAAATTGGGAGCGGCCTCAGTATTC
    TTAGGAACAATTATCGTTGTTGGAATGGGACAAGAAAAAGAAGCTGCAGCATCGGAACAA
    AACAATACTACAGTAGAGGAAAGTGGGAGTTCAGCTACTGAAAGTAAAGCAAGCGAAACA
    CAAACAACTACAAATAACGTTAATACAATAGATGAAACACAATCATACAGCGTGACATCA
    ACTGAGCAACCATCACAATCAACACAAGTAACAACAGAAGAAGCACCAACAACTGTGCAA
    GCACCAAAAGTAGAAACTTCGCGAGTTGATTTGCCATCGGAAAAAGTTGCTGATAAGGAA
    ACTACAGGAACTCAAGTTGACACAGCTCAACCAAGTAACTTCTCAGAAATTAAACCAAGA
    GTGAAAAGATCAGCTGACGTTGCCGTAGTAGCAGGAGAAGCTAAGGCGACAGGTACAGAT
    GTAACAAATAAAGTTACAGTAGAAAATGGTAGTGAAATTGTAGGACATAAACAAGATACG
    AATGTCGTTAATCCTCATAACGCTGAAAGAGTAACTTTAAAATATAAATGGAAATTCGGT
    GAAGGAATTAAAGAAGGAGATTATTTTGATTTCACGTTAAGTGATAATGTTGAAACTCAC
    GGTATTTCAACACTGCGTAAAGTTCCAGAAATAAAAAGTACAGATGGTCAAGTTATGGCA
    ATAGGTGAAGTGGTTGAAGAAAGAAAAATTAGATATACTTTTAAAGAGTACGTTAAAGAT
    AAAAAAGATTTAACTGCTGAATTATCTTTAAATCTATTTATTGACCCTACAACAGTGACA
    AAGCAAGGAAAGCAAAAAGTCGAAGTAACACTAGGTGATAAAACGATTGAAAAAGAGTTC
    GATATCAAATATTTAGACGGTGTTAAAGATAGAATGGGTGTAACTGTTAATGGTCGAATT
    GATACTTTGAATAAAGAAGATGGTAAATTTAGCCATTTTGCGTATATAAAACCTAATAAC
    CGATCGTTAAGCTCTGTCACAGTAACTGGTCAAGTAACATCTGGACATAAACAAAATGCT
    AATAATCCAACAGTCAAAGTATATAAACGCATTGGCTCAGATGAGTTAGCTGAAAGTGTT
    TATGCAAAGCTTGATGATGCCAGCAAATTTGAAGATGTGACTGAGAAAGTAAATCTATCT
    TATACAGGAGAAGGCGGATACTCATTCACATTTGATAGTTTAGAAGATAATAATAATTAT
    GTTGTCAAATATGAAGGAGAGTATAATACAAAGGCTAAAGACTTAAACTTTCAAACGAGA
    CTTACAGGTTACCATAACTACTATCCTTACTACCCATATTACCCAGTTCAATTAACTTGG
    AACAACGGCGTTGCATTTTACTCTAATAACGCTCAAGGCGACGGTAAAGATAAACCAAAG
    GAACCTATTATAGAACATAGTACTCCTATCGAACTTGAATTTAAATCAGAGCAGCCAGTG
    AAGAAGCATGAATTGACTGGTACAATCGAAGAAAGTAACGATTCTAAGCCAATTGATTTT
    GAATATCATACAGCTGTTGAAGGTGTAGAAGGTCATGCAGAAGGTATTATTGAAACTGAA
    GAAGATTCTATTCATGTGGATTTTGAAGAATCTACACATGAAAATTCAAAACATCACGCT
    GATGTTGTTGAATATGAAGAGGATACAAACCCAGGTGGTGGCCAAGTAACAACTGAGTCT
    AACTTAGTTGAATTTGACGAAGAGTCTACAAAAGGTATTGTAACTGGCGCAGTGAGCGAT
    CATACAACAGTTGAAGATACGAAAGAATATACAACTGAAAGTAATCTTATCGAACTAGTG
    GATGAATTACCTGAAGAACATGGTCAAGCACAAGGACCAATCGAGGAAATCACTGAAAAC
    AATCATTATATTTCTCATTCTGGTTTAGGAACTGAAAATGGTCACGGTAATTATGGCGTG
    ATTGAAGAAATCGAAGAAAATAGCCATGTTGATATTAAGAGTGAATTAGGTTACGAAGGT
    GGCCAAAATAGTGGTGATCAGTCATTCGAGGAAGACACAGAAAAAGACAAACCTAAGTAT
    GAACAAGGTGGTAATATCATTGATATCGACTTCGATAGTGTGCCACATATTCATGGATTC
    AATAAGCACACTGAAATTATTGAAGAAGATACAAACAAAGATAAACCTAATTATCAATTC
    GGTGGACACAGTAGTGTTGACTTTGAAGAAGATACACTTCCACAAGTAAGTGGTCATAAT
    GAAGGTCAACAAACGATTGAAGAAGATACAATACCTCCAATCGTGCCACCAACGCCACCG
    ACACCAGAAGTACCAAGCGAGCCGGAAACACCAACACCACCAACACCAGAAGTACCGAGT
    GAGCCAGGCGAACCAACGCCACCAACACCGGAAGTACCAAGTGAGCCGGAAACACCAGTA
    CCACCAACACCAGAGGTACCATCTGAACCTGGTAAACCAGTACCACCTGCTAAAGAAGAA
    CCTAAAAAACCTTCTAAACCAGTGGAACAAGGTAAAGTAGTAACACCTGTTATTGAAATC
    AATGAAAAGGTTAAAGCAGTGGCACCAACTAAACAAAAACAATCTAAGAAATCTGAACTA
    CCTGAAACAGGTGGAGAAGAATCAACAAACAAAGGTATGTTGTTCGGCGGAGTATTCAGC
    ATTTTAGGTTTAGCATTATTACGCAGAAATAAAAAGAATCACAAAGCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2751

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002479
  • symbol: FnbB
  • description: fibronectin-binding protein FnbB
  • length: 916
  • theoretical pI: 4.45387
  • theoretical MW: 100939
  • GRAVY: -0.866594

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 24.7)
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 21)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    Adhesin (CL0204) SdrG_C_C; C-terminus of bacterial fibrinogen-binding adhesin (PF10425; HMM-score: 119.7)
    and 4 more
    no clan defined Fn_bind; Fibronectin binding repeat (PF02986; HMM-score: 89)
    E-set (CL0159) Big_8; Bacterial Ig domain (PF17961; HMM-score: 87.1)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 33.3)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 30.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cell wall & surface Score: 0.9827
    • Extracellular Score: 0.0172
  • LocateP:
  • SignalP: Signal peptide SP(Sec/SPI) length 37 aa
    • SP(Sec/SPI): 0.878712
    • TAT(Tat/SPI): 0.010406
    • LIPO(Sec/SPII): 0.094755
    • Cleavage Site: CS pos: 37-38. AAA-SE. Pr: 0.7129
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKSNLRYGIRKHKLGAASVFLGTIIVVGMGQEKEAAASEQNNTTVEESGSSATESKASETQTTTNNVNTIDETQSYSVTSTEQPSQSTQVTTEEAPTTVQAPKVETSRVDLPSEKVADKETTGTQVDTAQPSNFSEIKPRVKRSADVAVVAGEAKATGTDVTNKVTVENGSEIVGHKQDTNVVNPHNAERVTLKYKWKFGEGIKEGDYFDFTLSDNVETHGISTLRKVPEIKSTDGQVMAIGEVVEERKIRYTFKEYVKDKKDLTAELSLNLFIDPTTVTKQGKQKVEVTLGDKTIEKEFDIKYLDGVKDRMGVTVNGRIDTLNKEDGKFSHFAYIKPNNRSLSSVTVTGQVTSGHKQNANNPTVKVYKRIGSDELAESVYAKLDDASKFEDVTEKVNLSYTGEGGYSFTFDSLEDNNNYVVKYEGEYNTKAKDLNFQTRLTGYHNYYPYYPYYPVQLTWNNGVAFYSNNAQGDGKDKPKEPIIEHSTPIELEFKSEQPVKKHELTGTIEESNDSKPIDFEYHTAVEGVEGHAEGIIETEEDSIHVDFEESTHENSKHHADVVEYEEDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPIEEITENNHYISHSGLGTENGHGNYGVIEEIEENSHVDIKSELGYEGGQNSGDQSFEEDTEKDKPKYEQGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPNYQFGGHSSVDFEEDTLPQVSGHNEGQQTIEEDTIPPIVPPTPPTPEVPSEPETPTPPTPEVPSEPGEPTPPTPEVPSEPETPVPPTPEVPSEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKQKQSKKSELPETGGEESTNKGMLFGGVFSILGLALLRRNKKNHKA

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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