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FunGene: 08-OCT-2024

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus JSNZ
  • locus tag: JSNZ_002537
  • pan locus tag?: SAUPAN006220000
  • symbol: JSNZ_002537
  • pan gene symbol?: copA
  • synonym:
  • product: heavy metal translocating P-type ATPase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: JSNZ_002537
  • symbol: JSNZ_002537
  • product: heavy metal translocating P-type ATPase
  • replicon: chromosome
  • strand: +
  • coordinates: 2544281..2546689
  • length: 2409
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Gene ID:
  • RefSeq:
  • BioCyc:
  • MicrobesOnline:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    GTGGCTAATACGAAAAAAACAACATTAGATATCACTGGTATGACTTGTGCCGCATGTTCA
    AATCGTATCGAAAAGAAACTGAATAAACTTGATGACGTTAATGCCCAAGTGAATTTAACT
    ACAGAGAAAGCAACTGTTGAGTATAACCCTAATCAACATGATGTCCAAGAATTTATTAAT
    ACGATTCAACATTTAGGTTACGGTGTCGCTGTAGAAACTGTCGAATTAGACATTACAGGT
    ATGACTTGTGCTGCATGCTCAAGCCGTATTGAAAAAGTGTTAAATAAAATGGACGGCGTT
    CAAAATGCAACGGTCAATTTAACAACAGAGCAAGCTAAAGTTGACTATTATCCTGAAGAA
    ACAGATGCTGATAAACTTGTCACTCGCATTCAAAAATTAGGTTATGACGCGTCTATTAAA
    GATAACAATAAAGATCAAACGTCACGCAAAGCGGAAGCGCTACAACATAAATTGATTAAG
    CTTATCATATCAACAGTATTATCTTTACCACTATTAATGTTAATGTTTGTGCATCTTTTC
    AATATGCATATACCAGCACTATTTACGAATCCATGGTTCCAATTTATTTTAGCTACACCT
    GTACAATTTATTATTGGATGGCAATTTTATGTAGGTGCTTATAAAAACTTAAGAAATGGT
    GGCGCCAATATGGATGTACTTGTTGCTGTTGGTACAAGTGCAGCATATTTTTACAGTATT
    TATGAAATGGTTCGTTGGCTAAATGGCTCAACAACGCAACCGCATTTATACTTTGAAACA
    AGCGCCGTACTAATTACCTTAATCTTATTCGGTAAGTATTTAGAAGCTCGAGCGAAGTCT
    CAAACAACCAATGCGCTTGGCGAATTATTAAGTTTGCAAGCTAAAGAAGCACGCATTTTA
    AAAGATGGTAATGAAGTGATGATTCCTCTAAATGAAGTACATGTTGGAGATACACTTATC
    GTTAAGCCAGGTGAAAAGATACCTGTTGATGGCAAAATTATTAAAGGTATGACTGCCATC
    GACGAATCTATGTTAACAGGTGAATCTATCCCTGTTGAGAAGAATGTTGATGATACTGTA
    ATTGGTTCAACGATGAACAAAAACGGTACTATTACTATGACAGCAACAAAAGTTGGCGGG
    GACACTGCGTTGGCAAATATTATTAAAGTTGTCGAAGAAGCTCAAAGTTCTAAAGCGCCG
    ATTCAACGATTGGCAGATATTATTTCTGGTTATTTCGTTCCTATCGTTGTTGGTATCGCA
    CTATTAACATTTATCGTGTGGATTACTTTAGTTACACCAGGTACATTTGAACCTGCACTT
    GTTGCGAGTATTTCCGTTCTTGTCATTGCTTGTCCATGCGCATTAGGACTTGCTACACCA
    ACTTCTATTATGGTAGGTACTGGTCGCGCTGCTGAAAATGGCATTTTATTTAAAGGTGGC
    GAGTTTGTTGAACGCACACATCAAATTGATACCATCGTTTTAGATAAGACGGGTACCATT
    ACAAATGGTCATCCAGTCGTGACAGATTATCATGGTGACAATCAAACGCTACAACTGCTT
    GCTACTGCTGAAAAAGATTCTGAACACCCATTGGCAGAAGCCATTGTCAATTATGCAAAA
    GAAAAGCAATTAACATTAACTGAGACAACAACATTTAAAGCAGTACCTGGCCATGGTATT
    GAAGCAACGATTGATCATCACCATATATTGGTTGGTAACCGTAAATTAATGGCTGACAAT
    GATATTAGCTTGCCTAAGCATATTTCTGATGATTTAACACATTATGAACGAGATGGTAAA
    ACTGCTATGCTCATTGCTGTTAATTATTCATTAACTGGTATCATCGCAGTGGCAGATACT
    GTAAAAGATCATGCCAAAGATGCTATAAAACAATTGCATGATATGGGCATTGAAGTTGCC
    ATGTTAACTGGCGATAATAAAAACACTGCTCAAGCCATTGCAAAACAAGTAGGCATAGAT
    ACTGTTATTGCAGATATTTTACCAGAAGAAAAAGCTGCACAAATTACGAAACTACAGCAA
    CAAGGTAAGAAGGTTGCGATGGTTGGTGACGGTGTAAATGATGCACCTGCATTAGTTAAA
    GCTGATATCGGTATCGCCATTGGTACAGGTACAGAAGTTGCCATTGAAGCAGCTGATATT
    ACTATTCTTGGTGGCGACTTGATGCTTATTCCTAAAGCCATTTATGCAAGTAAAGCAACC
    ATTCGTAATATTCGTCAAAATCTATTTTGGGCATTCGGCTATAATATTGCCGGTATCCCT
    ATAGCTGCATTGGGCTTACTTGCGCCATGGGTTGCTGGTGCTGCAATGGCACTAAGTTCA
    GTAAGTGTTGTCACAAACGCACTTAGATTGAAAAAAATGCGATTAGAACCACGCCGTAAA
    GATGCCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2409

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: JSNZ_002537
  • symbol: JSNZ_002537
  • description: heavy metal translocating P-type ATPase
  • length: 802
  • theoretical pI: 6.21519
  • theoretical MW: 86771.8
  • GRAVY: 0.096384

⊟Function[edit | edit source]

  • TIGRFAM:
    heavy metal translocating P-type ATPase (TIGR01525; EC 3.6.3.-; HMM-score: 672.6)
    Cellular processes Cellular processes Detoxification copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 633.2)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper-translocating P-type ATPase (TIGR01511; EC 3.6.3.4; HMM-score: 633.2)
    and 31 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds cadmium-translocating P-type ATPase (TIGR01512; EC 3.6.3.3; HMM-score: 425.9)
    HAD ATPase, P-type, family IC (TIGR01494; EC 3.6.3.-; HMM-score: 327.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds K+-transporting ATPase, B subunit (TIGR01497; EC 3.6.3.12; HMM-score: 205.9)
    plasma-membrane proton-efflux P-type ATPase (TIGR01647; EC 3.6.3.6; HMM-score: 186.7)
    calcium-translocating P-type ATPase, PMCA-type (TIGR01517; EC 3.6.3.8; HMM-score: 159.9)
    calcium-transporting P-type ATPase, PMR1-type (TIGR01522; EC 3.6.3.8; HMM-score: 138.9)
    Metabolism Energy metabolism ATP-proton motive force interconversion Na,H/K antiporter P-type ATPase, alpha subunit (TIGR01106; EC 3.6.3.-; HMM-score: 133.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds calcium-translocating P-type ATPase, SERCA-type (TIGR01116; EC 3.6.3.8; HMM-score: 132.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds magnesium-translocating P-type ATPase (TIGR01524; EC 3.6.3.2; HMM-score: 106.5)
    P-type ATPase of unknown pump specificity (type V) (TIGR01657; HMM-score: 104.1)
    potassium/sodium efflux P-type ATPase, fungal-type (TIGR01523; EC 3.6.3.-; HMM-score: 98.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds copper ion binding protein (TIGR00003; HMM-score: 73.3)
    Cellular processes Cellular processes Detoxification mercuric transport protein periplasmic component (TIGR02052; HMM-score: 67.2)
    Unknown function Enzymes of unknown specificity Cof-like hydrolase (TIGR00099; HMM-score: 39.3)
    Metabolism Amino acid biosynthesis Serine family phosphoserine phosphatase SerB (TIGR00338; EC 3.1.3.3; HMM-score: 29.2)
    phospholipid-translocating P-type ATPase, flippase (TIGR01652; EC 3.6.3.1; HMM-score: 28)
    phosphoserine phosphatase-like hydrolase, archaeal (TIGR01491; HMM-score: 24.6)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family (TIGR01670; EC 3.1.3.45; HMM-score: 23.7)
    phosphoglycolate phosphatase, TA0175-type (TIGR01487; EC 3.1.3.18; HMM-score: 23.6)
    Unknown function Enzymes of unknown specificity HAD phosphoserine phosphatase-like hydrolase, family IB (TIGR01488; HMM-score: 21.2)
    mannosyl-3-phosphoglycerate phosphatase family (TIGR01486; EC 3.1.3.-; HMM-score: 19.2)
    sucrose-phosphate phosphatase subfamily (TIGR01482; EC 3.1.3.-; HMM-score: 19)
    phosphonatase-like hydrolase (TIGR03351; HMM-score: 18.7)
    HAD hydrolase, TIGR01548 family (TIGR01548; HMM-score: 14.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other Fe-S cluster assembly protein NifU (TIGR02000; HMM-score: 14.7)
    Metabolism Central intermediary metabolism Nitrogen fixation Fe-S cluster assembly protein NifU (TIGR02000; HMM-score: 14.7)
    Unknown function Enzymes of unknown specificity HAD hydrolase, family IB (TIGR01490; HMM-score: 13.2)
    Cellular processes Cellular processes Pathogenesis type III secretion apparatus lipoprotein, YscJ/HrcJ family (TIGR02544; HMM-score: 11.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus lipoprotein, YscJ/HrcJ family (TIGR02544; HMM-score: 11.4)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 10.3)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 10.3)
  • TheSEED: data available for COL, N315, NCTC8325, Newman, USA300_FPR3757
  • PFAM:
    no clan defined E1-E2_ATPase; E1-E2 ATPase (PF00122; HMM-score: 199)
    and 18 more
    HAD (CL0137) Hydrolase; haloacid dehalogenase-like hydrolase (PF00702; HMM-score: 140)
    HMA (CL0704) HMA; Heavy-metal-associated domain (PF00403; HMM-score: 121.8)
    HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 30.3)
    HAD; haloacid dehalogenase-like hydrolase (PF12710; HMM-score: 22.7)
    TusA-like (CL0397) TusA; Sulfurtransferase TusA (PF01206; HMM-score: 20.3)
    HAD (CL0137) Hydrolase_6; haloacid dehalogenase-like hydrolase (PF13344; HMM-score: 19.3)
    HAD_2; haloacid dehalogenase-like hydrolase (PF13419; HMM-score: 17.2)
    no clan defined DUF2730; Protein of unknown function (DUF2730) (PF10805; HMM-score: 14.9)
    DUF6286; Family of unknown function (DUF6286) (PF19803; HMM-score: 14.4)
    DUF7573; Domain of unknown function (DUF7573) (PF24458; HMM-score: 14.3)
    DNM3A_N; DNA (cytosine-5-)-methyltransferase, N-terminal (PF22855; HMM-score: 14.1)
    PIN (CL0280) PIN_9; PIN like domain (PF18477; HMM-score: 13.9)
    RNase_H (CL0219) TNP-like_RNaseH_N; TNP-like, RNase H N-terminal domain (PF21787; HMM-score: 13.9)
    GlnB-like (CL0089) DUF190; Uncharacterized ACR, COG1993 (PF02641; HMM-score: 13.7)
    Glyoxalase (CL0104) YycE-like_C; YycE-like C-terminal domain (PF22659; HMM-score: 13.4)
    HMA (CL0704) HMA_2; Heavy metal associated domain 2 (PF19991; HMM-score: 13.3)
    Zn_Beta_Ribbon (CL0167) Zn_ribbon_DUF2089; DUF2089 zinc ribbon (PF22747; HMM-score: 11.9)
    no clan defined Spore_YhcN_YlaJ; Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) (PF09580; HMM-score: 8.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 9.99
    • Cellwall Score: 0.01
    • Extracellular Score: 0.01
    • Internal Helices: 8
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9998
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0002
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018112
    • TAT(Tat/SPI): 0.00102
    • LIPO(Sec/SPII): 0.398155
  • predicted transmembrane helices (TMHMM): 8

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq:
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPNQHDVQEFINTIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISTVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMVRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNEVMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGHPVVTDYHGDNQTLQLLATAEKDSEHPLAEAIVNYAKEKQLTLTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTVKDHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQITKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAADITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Blanca Taboada, Karel Estrada, Ricardo Ciria, Enrique Merino
    Operon-mapper: a web server for precise operon identification in bacterial and archaeal genomes.
    Bioinformatics: 2018, 34(23);4118-4120
    [PubMed:29931111] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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