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NCBI: 06-JUL-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_0604 [new locus tag: NWMN_RS03440 ]
  • pan locus tag?: SAUPAN002510000
  • symbol: feoA
  • pan gene symbol?: mntR
  • synonym:
  • product: iron dependent repressor

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_0604 [new locus tag: NWMN_RS03440 ]
  • symbol: feoA
  • product: iron dependent repressor
  • replicon: chromosome
  • strand: +
  • coordinates: 684492..685136
  • length: 645
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGTTAACTGAAGAAAAAGAGGACTATTTAAAGGCAATCCTTACGAATAATGGCGATAAA
    AACTTTGTGACAAATAAAATCTTATCTCAATTTTTAAATATTAAGCCTCCATCTGTAAGT
    GAAATGGTAGGACGTCTTGAAAAAGCAGGCTATGTTGAAACAAAACCATACAAAGGTGTT
    AGATTAACAGAGGATGGTTTAACGCATACGCTTGATATCATTAAGAGACATCGACTATTA
    GAATTATTTTTAATAGAAATATTGAAATATAATTGGGAAGAAGTACATCAAGAAGCAGAA
    ATTTTAGAACATCGAATTTCAGATTTATTTGTTGAAAGGCTGGATAGCCTGTTAAATTTC
    CCAGAAACTTGCCCGCACGGCGGTGTGATTCCTAGAAATAATGAATATAAAGAGAAATAT
    ATAACAACGATTTTGAATTATGAACCTGGTGATATCGTTACAATCAAACGTGTGAGAGAT
    AAGACCGATTTGCTAATATATTTGTCTAGTAAAGATATTTCTATTGGTAATGAAGTGGAA
    ATTGTATCGAAAGATGAAATGAATAAAGTAATTATCATTAAACGTAATGATAATGTAATT
    ATTGTCAGTTACGAAAATGCAATGAACATGTTTGCTGAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    645

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: NWMN_0604 [new locus tag: NWMN_RS03440 ]
  • symbol: FeoA
  • description: iron dependent repressor
  • length: 214
  • theoretical pI: 5.22243
  • theoretical MW: 24884.5
  • GRAVY: -0.356075

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    HTH (CL0123) Fe_dep_repr_C; Iron dependent repressor, metal binding and dimerisation domain (PF02742; HMM-score: 94.7)
    Fe_dep_repress; Iron dependent repressor, N-terminal DNA binding domain (PF01325; HMM-score: 87.1)
    and 10 more
    TRB (CL0206) FeoA; FeoA domain (PF04023; HMM-score: 30.9)
    HTH (CL0123) HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 25.1)
    MarR_2; MarR family (PF12802; HMM-score: 23.4)
    MarR; MarR family (PF01047; HMM-score: 21.2)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 19.3)
    Rrf2; Transcriptional regulator (PF02082; HMM-score: 19.2)
    HTH_27; Winged helix DNA-binding domain (PF13463; HMM-score: 18.5)
    Rio2_N; Rio2, N-terminal (PF09202; HMM-score: 15.3)
    TrmB; Sugar-specific transcriptional regulator TrmB (PF01978; HMM-score: 13.2)
    AbrB (CL0132) MazE_antitoxin; Antidote-toxin recognition MazE, bacterial antitoxin (PF04014; HMM-score: 10)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effector: Manganese ion (Mn2+)
  • genes regulated by MntR*, TF important in Manganese homeostasisRegPrecise
    repression
    mntC* < mntB* < mntA*
    transcription unit transferred from N315 data RegPrecise

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • LocateP: Intracellular
    • Prediction by SwissProt Classification: Cytoplasmic
    • Pathway Prediction: No pathway
    • Intracellular possibility: 1
    • Signal peptide possibility: -1
    • N-terminally Anchored Score: -1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005799
    • TAT(Tat/SPI): 0.001989
    • LIPO(Sec/SPII): 0.001196
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLTEEKEDYLKAILTNNGDKNFVTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHRLLELFLIEILKYNWEEVHQEAEILEHRISDLFVERLDSLLNFPETCPHGGVIPRNNEYKEKYITTILNYEPGDIVTIKRVRDKTDLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDNVIIVSYENAMNMFAEK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell: data available for COL
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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