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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 06-JUL-2013

Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_1924 [new locus tag: NWMN_RS11105 ]
  • pan locus tag?: SAUPAN005161000
  • symbol: NWMN_1924
  • pan gene symbol?: hlb
  • synonym:
  • product: hypothetical protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_1924 [new locus tag: NWMN_RS11105 ]
  • symbol: NWMN_1924
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2130661..2131125
  • length: 465
  • essential: unknown

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGAAAAGATTGTTAGGTTTATTATTAGTGAGCACGTTAGTGTTAAGTGCATGTGGAAAT
    GATGAGAATCAGGAAGAATCTAAAAAAGAAGTTAAATCAAAAGAAAAGAAAATTGAGAAG
    GAAAAGGAAAATAAATCGAAAAAAGATAAGGAAAAAGAAGTTGCAACACAACAACAACCA
    GACAATCAAACCGTTGAACAACCCCAATCACAAGAGCAATCGGTTCAACAACCGCAACAA
    CAGATACCACAAAATAGTGTTCCTCAGCAAAATGTCCAAGTTCAACAAAACAAAAAGCAA
    AAAGTTGATTTAAATAATATGCCTCCCACTGATTTTTCTACAGAGGGTATGTCTGAGCAG
    GCTCAAAAACAAATTGAAGAGCTTTCAATGCAAAAAGACTATCATGGTCTGTCACAAAGA
    GAATACAATGATAGAGTTTCTGAAATTATAAATAATGATAATTGA
    60
    120
    180
    240
    300
    360
    420
    465

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: NWMN_1924 [new locus tag: NWMN_RS11105 ]
  • symbol: NWMN_1924
  • description: hypothetical protein
  • length: 154
  • theoretical pI: 4.93322
  • theoretical MW: 17766.5
  • GRAVY: -1.44545

Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Sporulation and germination sporulation lipoprotein, YhcN/YlaJ family (TIGR02898; HMM-score: 15.1)
    and 9 more
    Cellular processes Cellular processes Cell division cell division protein ZipA (TIGR02205; HMM-score: 9.4)
    cobaltochelatase subunit (TIGR02442; EC 6.6.1.2; HMM-score: 8.8)
    Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 8.1)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cation transporter family protein (TIGR00860; HMM-score: 7.1)
    Cellular processes Cellular processes Pathogenesis putative immunoglobulin-blocking virulence protein (TIGR04526; HMM-score: 6.5)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 4.7)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 3.4)
    Genetic information processing Transcription Degradation of RNA ribonuclease Y (TIGR03319; EC 3.1.-.-; HMM-score: 3)
    Metabolism Transport and binding proteins Other K-Cl cotransporter (TIGR00930; HMM-score: 2.5)
  • TheSEED:
  • PFAM:
    no clan defined Trypan_PARP; Procyclic acidic repetitive protein (PARP) (PF05887; HMM-score: 17.1)
    ETRAMP; Malarial early transcribed membrane protein (ETRAMP) (PF09716; HMM-score: 15.6)
    DUF4887; Domain of unknown function (DUF4887) (PF16228; HMM-score: 14.4)
    and 14 more
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family (PF15686; HMM-score: 12.4)
    Lipase_bact_N; Bacterial virulence factor lipase N-terminal (PF12262; HMM-score: 12.3)
    LppaM (CL0421) LPAM_2; Prokaryotic lipoprotein-attachment site (PF13627; HMM-score: 11.9)
    no clan defined Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region (PF04696; HMM-score: 11.6)
    TP53IP5; Cellular tumour antigen p53-inducible 5 (PF15331; HMM-score: 11.4)
    DUF4969; Domain of unknown function (DUF4969) (PF16339; HMM-score: 11.2)
    Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 8.6)
    AhpD-like (CL0423) PA26; PA26 p53-induced protein (sestrin) (PF04636; HMM-score: 8.4)
    FUSC (CL0307) ALMT; Aluminium activated malate transporter (PF11744; HMM-score: 7.1)
    P-loop_NTPase (CL0023) LAP1C; Lamina-associated polypeptide 1C (LAP1C) (PF05609; HMM-score: 6.6)
    GPCR_A (CL0192) SID-1_RNA_chan; dsRNA-gated channel SID-1 (PF13965; HMM-score: 6.4)
    no clan defined Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 6.2)
    Lin-8; Ras-mediated vulval-induction antagonist (PF03353; HMM-score: 6.2)
    SLC12; Solute carrier family 12 (PF03522; HMM-score: 5.9)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 3.33
    • Cellwall Score: 3.33
    • Extracellular Score: 3.33
    • Internal Helices: 0
  • LocateP: Lipid anchored
    • Prediction by SwissProt Classification: Extracellular
    • Pathway Prediction: Sec-(SPII)
    • Intracellular possibility: -0.33
    • Signal peptide possibility: 1
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: VLSACGN
  • SignalP: Signal peptide LIPO(Sec/SPII) length 17 aa
    • SP(Sec/SPI): 0.000386
    • TAT(Tat/SPI): 0.000086
    • LIPO(Sec/SPII): 0.999259
    • Cleavage Site: CS pos: 17-18. LSA-CG. Pr: 0.9999
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MKRLLGLLLVSTLVLSACGNDENQEESKKEVKSKEKKIEKEKENKSKKDKEKEVATQQQPDNQTVEQPQSQEQSVQQPQQQIPQNSVPQQNVQVQQNKKQKVDLNNMPPTDFSTEGMSEQAQKQIEELSMQKDYHGLSQREYNDRVSEIINNDN

Experimental data[edit | edit source]

  • experimentally validated:
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]