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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus Newman
  • locus tag: NWMN_RS02615 [old locus tag: NWMN_0458 ]
  • pan locus tag?: SAUPAN002233000
  • symbol: NWMN_RS02615
  • pan gene symbol?: ipk
  • synonym:
  • product: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: NWMN_RS02615 [old locus tag: NWMN_0458 ]
  • symbol: NWMN_RS02615
  • product: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 520719..521567
  • length: 849
  • essential: unknown other strains

Accession numbers[edit | edit source]

  • Location: NC_009641 (520719..521567) NCBI
  • BioCyc:
  • MicrobesOnline: see NWMN_0458

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGATATATGAAACGGCACCAGCCAAAATTAATTTTACGCTCGATACACTTTTTAAAAGA
    AATGATGGCTATCATGAGATTGAAATGATAATGACAACAGTTGATTTAAATGATCGTTTA
    ACTTTTCATAAAAGAAAAGATCGAAAGATAGTTGTTGAGATTGAACATAATTATGTGCCT
    TCTAATCATAAAAATCTCGCATATCGTGCAGCGCAACTATTTATTGAGCAATATCAACTA
    AAGCAAGGTGTAACAATTTCTATCGATAAAGAAATACCTGTTTCTGCTGGCTTAGCTGGA
    GGTTCGGCTGATGCAGCAGCAACGTTAAGAGGATTGAATCGACTTTTTGATATAGGGGCG
    AGTTTGGAAGAATTGGCTCTACTAGGCAGTAAAATCGGGACAGATATTCCGTTTTGTATT
    TATAATAAAACTGCACTATGTACTGGAAGAGGAGAGAAAATCGAGTTTTTAAATAAACCA
    CCTTCAGCTTGGGTGATTCTTGCTAAACCAAACTTAGGCATATCATCACCAGATATATTT
    AAGTTGATTAATTTAGATAAGCGTTACGACGTACATACGAAAATGTGTTATGAGGCCTTA
    GAAAATCGAGATTATCAACAATTATGTCAAAGTTTGTCTAATCGATTAGAGCCAATTTCT
    GTTTCAAAACACCCACAAATCGATAAATTAAAAAATAATATGTTGAAAAGTGGTGCAGAT
    GGTGCGTTAATGAGTGGAAGCGGACCTACTGTGTATGGGCTAGCACGAAAAGAAAGCCAA
    GCAAAAAATATTTATAATGCAGTTAACGGTTGTTGTAATGAAGTGTACTTAGTTAGACTA
    TTAGGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    849

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: NWMN_RS02615 [old locus tag: NWMN_0458 ]
  • symbol: NWMN_RS02615
  • description: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
  • length: 282
  • theoretical pI: 8.54156
  • theoretical MW: 31442
  • GRAVY: -0.251064

Function[edit | edit source]

  • reaction:
    EC 2.7.1.148?  ExPASy
    4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (TIGR00154; EC 2.7.1.148; HMM-score: 297.4)
    and 5 more
    Metabolism Amino acid biosynthesis Aspartate family homoserine kinase (TIGR00191; EC 2.7.1.39; HMM-score: 52.3)
    Metabolism Central intermediary metabolism Other mevalonate kinase (TIGR00549; EC 2.7.1.36; HMM-score: 39)
    Metabolism Amino acid biosynthesis Aromatic amino acid family shikimate kinase (TIGR01920; EC 2.7.1.71; HMM-score: 35.2)
    Unknown function Enzymes of unknown specificity beta-ribofuranosylaminobenzene 5'-phosphate synthase family (TIGR00144; HMM-score: 13.9)
    Metabolism Central intermediary metabolism Other diphosphomevalonate decarboxylase (TIGR01240; EC 4.1.1.33; HMM-score: 12.3)
  • TheSEED: data available for COL, N315, NCTC8325, USA300_FPR3757
  • PFAM:
    no clan defined GHMP_kinases_C; GHMP kinases C terminal (PF08544; HMM-score: 44.5)
    S5 (CL0329) GHMP_kinases_N; GHMP kinases N terminal domain (PF00288; HMM-score: 44.2)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001934
    • TAT(Tat/SPI): 0.000105
    • LIPO(Sec/SPII): 0.000429
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MIYETAPAKINFTLDTLFKRNDGYHEIEMIMTTVDLNDRLTFHKRKDRKIVVEIEHNYVPSNHKNLAYRAAQLFIEQYQLKQGVTISIDKEIPVSAGLAGGSADAAATLRGLNRLFDIGASLEELALLGSKIGTDIPFCIYNKTALCTGRGEKIEFLNKPPSAWVILAKPNLGISSPDIFKLINLDKRYDVHTKMCYEALENRDYQQLCQSLSNRLEPISVSKHPQIDKLKNNMLKSGADGALMSGSGPTVYGLARKESQAKNIYNAVNGCCNEVYLVRLLG

Experimental data[edit | edit source]

  • experimentally validated: data available for COL, NCTC8325
  • protein localization: data available for COL
  • quantitative data / protein copy number per cell:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]