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NCBI: 26-AUG-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus N315
  • locus tag: SA0384 [new locus tag: SA_RS02195 ]
  • pan locus tag?: SAUPAN002108000
  • symbol: set8
  • pan gene symbol?: ssl3
  • synonym:
  • product: superantigen-like protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SA0384 [new locus tag: SA_RS02195 ]
  • symbol: set8
  • product: superantigen-like protein
  • replicon: chromosome
  • strand: +
  • coordinates: 443054..444124
  • length: 1071
  • essential: no DEG other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    ATGAATATGAAAACAATTGCTAAAACCAGTTTAGCACTAGGGCTTTTAACAACAGGCGCA
    ATTACAGTAACGACGCAATCGGTCAAAGCAGAAAAAATACAATCAACTAAAGTTGACAAA
    GTACCAACGCTTAAAGCAGAGCGATTAGCAATGATAAACATAACAGCAGGTGCAAATTCA
    GCGACAACACAAGCAGCTAACACAAGACAAGAACGCACGCCTAAACTCGAAAAGGCACCA
    AATACTAATGAGGAAAAAACCTCAGCTTCCAAAATAGAAAAAATATCACAACCTAAACAA
    GAAGAGCAGAAATCGCTTAATATATCAGCAACGCCAGCGCCTAAACAAGAACAATCACAA
    ACGACAACCGAATCCACAACGCCGAAAACTAAAGTGACAACACCTCCATCAACAAACACG
    CCACAACCAATGCAATCTACTAAATCAGACACACCACAATCTCCAACCATAAAACAAGCA
    CAAACAGATATGACTCCTAAATATGAAGATTTAAGAGCGTATTACACGAAACCGAGTTTT
    GAATTTGAAAAGCAGTTTGGATTTTTGCTCAAACCATGGACGACGGTTAGGTTTATGAAT
    GTTATTCCAAATAGGTTCATCTATAAAATAGCTTTAGTTGGAAAAGATGAGAAAAAATAT
    AAAGATGGACCTTACGATAATATCGATGTATTTATCGTTTTAGAAGACAATAAATATCAA
    TTAAAAAAATATTCTGTCGGTGGCATCACGAAGACTAATAGTAAAAAAGTTGATCACAAA
    GCAGAATTAAGCGTTACTAAAAAAGATAATCAAGGTATGATTTCACGCGATGTTTCAGAA
    TACATGATTACTAAGGAAGAGATTTCCTTGAAAGAGCTTGATTTTAAATTGAGAAAACAA
    CTTATTGAAAAACATAATCTTTACGGTAACATGGGTTCAGGAACAATCGTTATTAAAATG
    AAAAACGGTGGGAAGTATACGTTTGAATTACACAAAAAACTGCAAGAGCATCGTATGGCA
    GATGTCATAGAAGGTACAAACATTGATAAAATTGAAGTGAATATAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1071

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SA0384 [new locus tag: SA_RS02195 ]
  • symbol: Set8
  • description: superantigen-like protein
  • length: 356
  • theoretical pI: 10.2005
  • theoretical MW: 40093.7
  • GRAVY: -0.76573

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin hydroxymethylbilane synthase (TIGR00212; EC 2.5.1.61; HMM-score: 11.9)
  • TheSEED  :
    • Phage exotoxin
  • PFAM:
    OB_enterotoxin (CL0658) SSL_OB; Staphylococcal superantigen-like OB-fold domain (PF09199; HMM-score: 110.5)
    and 4 more
    Ant-toxin_C (CL0386) Stap_Strp_tox_C; Staphylococcal/Streptococcal toxin, beta-grasp domain (PF02876; HMM-score: 30.6)
    no clan defined DUF4551; Protein of unknown function (DUF4551) (PF15087; HMM-score: 7.4)
    Ndc1_Nup; Nucleoporin protein Ndc1-Nup (PF09531; HMM-score: 7.3)
    Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 5.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0
    • Extracellular Score: 10
    • Internal Helices: 0
  • LocateP: N-terminally anchored (No CS)
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: -0.17
    • Signal peptide possibility: 1
    • N-terminally Anchored Score: 7
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: Signal peptide SP(Sec/SPI) length 30 aa
    • SP(Sec/SPI): 0.975093
    • TAT(Tat/SPI): 0.00843
    • LIPO(Sec/SPII): 0.008764
    • Cleavage Site: CS pos: 30-31. VKA-EK. Pr: 0.9290
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNMKTIAKTSLALGLLTTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQAANTRQERTPKLEKAPNTNEEKTSASKIEKISQPKQEEQKSLNISATPAPKQEQSQTTTESTTPKTKVTTPPSTNTPQPMQSTKSDTPQSPTIKQAQTDMTPKYEDLRAYYTKPSFEFEKQFGFLLKPWTTVRFMNVIPNRFIYKIALVGKDEKKYKDGPYDNIDVFIVLEDNKYQLKKYSVGGITKTNSKKVDHKAELSVTKKDNQGMISRDVSEYMITKEEISLKELDFKLRKQLIEKHNLYGNMGSGTIVIKMKNGGKYTFELHKKLQEHRMADVIEGTNIDKIEVNIK

⊟Experimental data[edit | edit source]

  • experimentally validated: data available for NCTC8325
  • protein localization:
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Stefan Monecke, Peter Slickers, Ralf Ehricht
Assignment of Staphylococcus aureus isolates to clonal complexes based on microarray analysis and pattern recognition.
FEMS Immunol Med Microbiol: 2008, 53(2);237-51
[PubMed:18507678] [WorldCat.org] [DOI] (P p)

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