PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

NCBI: 10-JUN-2013

⊟Summary

• organism: Staphylococcus aureus COL
• locus tag: SACOL0885 [new locus tag: SACOL_RS04545 ]
• pan locus tag^?: SAUPAN002841000
• symbol: SACOL0885
• pan gene symbol^?: int
• synonym:
• product: pathogenicity island protein, integrase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SACOL0885 [new locus tag: SACOL_RS04545 ]
• symbol: SACOL0885
• product: pathogenicity island protein, integrase
• replicon: chromosome
• strand: -
• coordinates: 903491..904711
• length: 1221
• essential: unknown

⊟Accession numbers

• Gene ID: 3238598 NCBI
• RefSeq: YP_185756 NCBI
• BioCyc: see SACOL_RS04545
• MicrobesOnline: 912356 MicrobesOnline

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  ATGTGGTTAGAAAAATTTAAAAATAAGAATAAAGAAACTAAATATAGATATTACGAGAAG
  TACAAAGACCCTCTCACTGCCAAATGGAGACGTGTTAGCGTGGTACTTAATAAGAATGGT
  AAGCAATCACAAAAAGAAGCTCAAAGACTCTTAAATGAGCGTATAGAAGCAAAACTGAAT
  GATAAGACACCTACTACACTTAAGTCACTAACTTTCCATGTCGCATGTGATGAGTGGTTT
  CAGAGTTATATCAAAACGTCTGGGTCAAAAAGAACAACTATTAAAACTAAATTGAGTAAG
  CTAAACACTTTGAAGAAATTTGTAGATGAAGATATTTTAATCAATAAAATAACACTTTCA
  TATGCGCAACAAGTTTTCGATGAAATGGATAATAAAGGTTATGTATATCAAGTAAACAAA
  GATGCGTTAAGCATATTCAAAAATGTATTTGAATACACTAGACGTATCTATAAACTGCAA
  GATTTAGAATTTTTAAAAGATATAACGTTAAATAAAAGAATTAAGTCTTATGATGAAGTG
  AAAGCTAAACGTAATAAGTACCTCGAATTAAATGAAATACAATCTATCATCAAAGATATT
  AATACGAAGGCTCAGAAGATGCACTCAGGTATCCATAAGCGGTTTTATTTATTCGTTGCA
  CTCATGACAGAATTCCAAGCCTTAAATGGTATGCGTATTGGTGAAATGTTAGCCATTCAA
  AATGAAGATATAGACTTTGATAATAAGAGTTTAAATATTAACGGAACAATCCATTGGTTT
  CACGATGAATCTGGTGGATTCGGTGTAAAAGATACCACTAAAACAGAGTCTAGTTATAGA
  ACAATTGGATTGAGTAGCAGAAGTTGCGAGATATTAAAGAAAGCAATACTGGAGAACAAA
  AAGGATTCAAAATGGAATGATGGATATCTAAATAGAAATTTTGTATTTACTAATCATAAA
  GGCAACCCAATGCAGACTGAAAGATTCAATAAAATCCTTAGGGAAGCAGCTAAAGATGTT
  GGTATTGATAAAGAAGTTTCTTCACATATATTAAGACATAGCCACATATCATTACTCTCT
  CAACAAGGCGTGTCACTTAAAGCTATTATGGATCGTGTAGGCCATTCCGACCACCGTACA
  ACACTTTCCATTTATTCTCACGTTACTGAACAGATGGATAAGGATATGATGAACAAACTT
  GAACAGGTAAAACTTGGATAA
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⊟Protein

⊟General

• locus tag: SACOL0885 [new locus tag: SACOL_RS04545 ]
• symbol: SACOL0885
• description: pathogenicity island protein, integrase
• length: 406
• theoretical pI: 10.1504
• theoretical MW: 47586.3
• GRAVY: -0.724384

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair tyrosine recombinase XerD (TIGR02225; HMM-score: 79.1)
  and 3 more
  Genetic information processing DNA metabolism DNA replication, recombination, and repair tyrosine recombinase XerC (TIGR02224; HMM-score: 58.8)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair integron integrase (TIGR02249; HMM-score: 58.7)
  Genetic information processing Mobile and extrachromosomal element functions Other integron integrase (TIGR02249; HMM-score: 58.7)
• TheSEED  :
  • Integrase, superantigen-encoding pathogenicity islands SaPI
  Phages, Prophages, Transposable elements, Plasmids Pathogenicity islands Staphylococcal pathogenicity islands SaPI  Integrase, superantigen-encoding pathogenicity islands SaPI
• PFAM:
  DNA-mend (CL0382) Phage_integrase; Phage integrase family (PF00589; HMM-score: 105.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• LocateP: Intracellular
  • Prediction by SwissProt Classification: Cytoplasmic
  • Pathway Prediction: No pathway
  • Intracellular possibility: 1
  • Signal peptide possibility: -1
  • N-terminally Anchored Score: 1
  • Predicted Cleavage Site: No CleavageSite
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.011643
  • TAT(Tat/SPI): 0.000629
  • LIPO(Sec/SPII): 0.004835
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI: 57650158 NCBI
• RefSeq: YP_185756 NCBI
• UniProt: A0A0H2WVV9 UniProt

⊟Protein sequence

• MWLEKFKNKNKETKYRYYEKYKDPLTAKWRRVSVVLNKNGKQSQKEAQRLLNERIEAKLNDKTPTTLKSLTFHVACDEWFQSYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLSYAQQVFDEMDNKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEVKAKRNKYLELNEIQSIIKDINTKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIQNEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENKKDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILREAAKDVGIDKEVSSHILRHSHISLLSQQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG

⊟Experimental data

• experimentally validated:
• protein localization:
• quantitative data / protein copy number per cell:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: no polycistronic organisation predicted

⊟Regulation

• regulator:

⊟Transcription pattern

• S.aureus Expression Data Browser: no data available

⊟Protein synthesis (provided by Aureolib)

• Aureolib: no data available

⊟Protein stability

• half-life: no data available

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications