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PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN002841000
  • symbol?: int
  • synonym:
  • description?: site-specific integrase

      descriptions from strain specific annotations:

    • site-specific integrase
    • integrase
    • pathogenicity island protein, integrase
    • prophage L54a integrase
  • strand?: -
  • coordinates?: 3292431..3294379
  • synteny block?: BlockID0020250
  • occurrence?: in 26% of 34 strains

intIV : metQ-converting satellite pathogenicity island site-specific integrase [1]

• A crystal structure is available : 3NKH

This satellite pathogenicity island integrase catalyzes insertion of staphylococcal satellite pathogenicity islands at the consensus attB sequence TTATTCCTGCTAAATAA within the methionine import methionine-binding protein located between metP and csbD1. MetQ-converting (type IV) satellite pathogenicity islands such as SaPI3 and SaPI1 typically encode virulence factors such as enterotoxin K and enterotoxin Q.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    JSNZ:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    SAAV_0787
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    SAA6008_00838 (int)
    JKD6159:
    LGA251:
    SARLGA251_07460
    M013:
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_00915 (rbsU)
    TCH60:
    HMPREF0772_12363 (int3)
    TW20:
    SATW20_08890
    USA300_TCH1516:
    USA300HOU_0850
    VC40:

Genome Viewer[edit | edit source]

COL
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.505)


    COL             MWLEKFKNKNKETKYRYYEKYKDPLTAKWRRVSVVLNKNGKQSQKEAQRLLNERIEAKLN
    USA300_FPR3757  MWLEKFKNKNKETKYRYYEKYKDPLTAKWRRVSVVLNKNGKQSQKEAQRLLNERIEEKLN
                    ******************************************************** ***

    COL             DKTPTTLKSLTFHVACDEWFQSYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLS
    USA300_FPR3757  DKKPTTLKSLTFHVACDEWFQNYIKTSGSKRTTIKTKLSKLNTLKKFVDEDILINKITLS
                    **.******************.**************************************

    COL             YAQQVFDEMDNKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEV
    USA300_FPR3757  YAQQVFDEMDSKGYVYQVNKDALSIFKNVFEYTRRIYKLQDLEFLKDITLNKRIKSYDEV
                    **********.*************************************************

    COL             KAKRNKYLELNEIQSIIKDINTKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIQ
    USA300_FPR3757  KAKRNKYLELNEIESIIKDINTKAQKMHSGIHKRFYLFVALMTEFQALNGMRIGEMLAIQ
                    *************:**********************************************

    COL             NEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENK
    USA300_FPR3757  NEDIDFDNKSLNINGTIHWFHDESGGFGVKDTTKTESSYRTIGLSSRSCEILKKAILENK
                    ************************************************************

    COL             KDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILREAAKDVGIDKEVSSHILRHSHISLLS
    USA300_FPR3757  KDSKWNDGYLNRNFVFTNHKGNPMQTERFNKILREAAKDVGIDKEVSSHILRHSHISLLS
                    ************************************************************

    COL             QQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG
    USA300_FPR3757  QQGVSLKAIMDRVGHSDHRTTLSIYSHVTEQMDKDMMNKLEQVKLG
                    **********************************************

  1. Babek Alibayov, Kamila Zdenkova, Hana Sykorova, Katerina Demnerova
    Molecular analysis of Staphylococcus aureus pathogenicity islands (SaPI) and their superantigens combination of food samples.
    J Microbiol Methods: 2014, 107;197-204
    [PubMed:25447888] [WorldCat.org] [DOI] (I p)
    Mercedes Cervera-Alamar, Katerina Guzmán-Markevitch, Miglė Žiemytė, Leticia Ortí, Patricia Bernabé-Quispe, Antonio Pineda-Lucena, Javier Pemán, María Ángeles Tormo-Mas
    Mobilisation Mechanism of Pathogenicity Islands by Endogenous Phages in Staphylococcus aureus clinical strains.
    Sci Rep: 2018, 8(1);16742
    [PubMed:30425253] [WorldCat.org] [DOI] (I e)
    Andreas F Haag, Magdalena Podkowik, Rodrigo Ibarra-Chávez, Francisca Gallego Del Sol, Geeta Ram, John Chen, Alberto Marina, Richard P Novick, José R Penadés
    A regulatory cascade controls Staphylococcus aureus pathogenicity island activation.
    Nat Microbiol: 2021, 6(10);1300-1308
    [PubMed:34518655] [WorldCat.org] [DOI] (I p)