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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN002842000
  • symbol?: sek
  • synonym:
  • description?: staphylococcal enterotoxin K

      descriptions from strain specific annotations:

    • staphylococcal enterotoxin K
    • exotoxin
    • enterotoxin
    • enterotoxin K
    • extracellular enterotoxin type I
  • strand?: -
  • coordinates?: 3294543..3295271
  • synteny block?: BlockID0020260
  • occurrence?: in 18% of 34 strains

sek2 (sek, selk, entK) : enterotoxin K [1]

• A crystal structure is available : 3EA6

Staphylococcal enterotoxins are superantigens with potent T-cell stimulating activity through MHC class II binding. However, they are most well-known for their association with emetic food-borne illness and toxic shock syndrome. Staphylococcal enterotoxins can be structurally subdivided into classical staphylococcal enterotoxin (SE) or staphylococcal enterotoxin-like (SEl) although functional characterization of SEl suggests emetic potential does not divide cleanly along structural lines. Staphylococcal enterotoxin K was initially assigned to the "SEl" group (i.e. "selk") based on structure but reassigned as "sek" after functional characterization. This version is found on a mobile genetic element (frequently a satellite pathogenicity island) so, to differentiate it from other potential sek coding sequences, it is assigned the gene name "sek2" by default.

Orthologs[edit | edit source]

    COL:
    SACOL0886 (sek)
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    JH1:
    JH9:
    JKD6008:
    SAA6008_00839 (sei)
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_00916
    TCH60:
    TW20:
    SATW20_08900 (entK)
    USA300_TCH1516:
    USA300HOU_0851
    VC40:

Genome Viewer[edit | edit source]

COL
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKKLISILLINIIILGVSNSASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQF
    USA300_FPR3757  MKKLIVIILINIITLSVSNSASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQF
                    ***** *:***** *.********************************************

    COL             SNESYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNTKYIYGGVTATNEYLDKSRNIPI
    USA300_FPR3757  SNVSYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNNKYIYGGVTATNEYLDKPRNIPI
                    ** **********************************.****************.*****

    COL             NIWINGNHKTISTNKVSTNKKFVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKF
    USA300_FPR3757  NIWINGNHKTISTNKVSTNKKFVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKF
                    ************************************************************

    COL             YSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKE
    USA300_FPR3757  YSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKE
                    ************************************************************

    COL             TI
    USA300_FPR3757  TI
                    **

  1. Paul Sumby, Matthew K Waldor
    Transcription of the toxin genes present within the Staphylococcal phage phiSa3ms is intimately linked with the phage's life cycle.
    J Bacteriol: 2003, 185(23);6841-51
    [PubMed:14617648] [WorldCat.org] [DOI] (P p)
    Irina V Pinchuk, Ellen J Beswick, Victor E Reyes
    Staphylococcal enterotoxins.
    Toxins (Basel): 2010, 2(8);2177-97
    [PubMed:22069679] [WorldCat.org] [DOI] (I p)
    Katsuhiko Omoe, Dong-Liang Hu, Hisaya K Ono, Satoru Shimizu, Hiromi Takahashi-Omoe, Akio Nakane, Takehiko Uchiyama, Kunihiro Shinagawa, Ken'ichi Imanishi
    Emetic potentials of newly identified staphylococcal enterotoxin-like toxins.
    Infect Immun: 2013, 81(10);3627-31
    [PubMed:23876808] [WorldCat.org] [DOI] (I p)