⊟Summary[edit | edit source]
- pan ID?: SAUPAN002842000
- symbol?: sek
- synonym:
- description?: staphylococcal enterotoxin K
- staphylococcal enterotoxin K
- exotoxin
- enterotoxin
- enterotoxin K
- extracellular enterotoxin type I
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3294543..3295271
- synteny block?: BlockID0020260
- occurrence?: in 18% of 34 strains
sek2 (sek, selk, entK) : enterotoxin K [1]
• A crystal structure is available : 3EA6
Staphylococcal enterotoxins are superantigens with potent T-cell stimulating activity through MHC class II binding. However, they are most well-known for their association with emetic food-borne illness and toxic shock syndrome. Staphylococcal enterotoxins can be structurally subdivided into classical staphylococcal enterotoxin (SE) or staphylococcal enterotoxin-like (SEl) although functional characterization of SEl suggests emetic potential does not divide cleanly along structural lines. Staphylococcal enterotoxin K was initially assigned to the "SEl" group (i.e. "selk") based on structure but reassigned as "sek" after functional characterization. This version is found on a mobile genetic element (frequently a satellite pathogenicity island) so, to differentiate it from other potential sek coding sequences, it is assigned the gene name "sek2" by default.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKKLISILLINIIILGVSNSASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQF
USA300_FPR3757 MKKLIVIILINIITLSVSNSASAQGDIGIDNLRNFYTKKDFVDLKDVKDNDTPIANQLQF
***** *:***** *.********************************************
COL SNESYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNTKYIYGGVTATNEYLDKSRNIPI
USA300_FPR3757 SNVSYDLISESKDFNKFSNFKGKKLDVFGISYNGQCNNKYIYGGVTATNEYLDKPRNIPI
** **********************************.****************.*****
COL NIWINGNHKTISTNKVSTNKKFVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKF
USA300_FPR3757 NIWINGNHKTISTNKVSTNKKFVTAQEIDVKLRKYLQEEYNIYGHNGTKKGEEYGHKSKF
************************************************************
COL YSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKE
USA300_FPR3757 YSGFNIGKVTFHLNNNDTFSYDLFYTGDDGLPKSFLKIYEDNKTVESEKFHLDVDISYKE
************************************************************
COL TI
USA300_FPR3757 TI
**
- ↑ Paul Sumby, Matthew K Waldor
Transcription of the toxin genes present within the Staphylococcal phage phiSa3ms is intimately linked with the phage's life cycle.
J Bacteriol: 2003, 185(23);6841-51
[PubMed:14617648] [WorldCat.org] [DOI] (P p)Irina V Pinchuk, Ellen J Beswick, Victor E Reyes
Staphylococcal enterotoxins.
Toxins (Basel): 2010, 2(8);2177-97
[PubMed:22069679] [WorldCat.org] [DOI] (I p)Katsuhiko Omoe, Dong-Liang Hu, Hisaya K Ono, Satoru Shimizu, Hiromi Takahashi-Omoe, Akio Nakane, Takehiko Uchiyama, Kunihiro Shinagawa, Ken'ichi Imanishi
Emetic potentials of newly identified staphylococcal enterotoxin-like toxins.
Infect Immun: 2013, 81(10);3627-31
[PubMed:23876808] [WorldCat.org] [DOI] (I p)