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NCBI: 10-JUN-2013

⊟Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL2037 [new locus tag: SACOL_RS10635 ]
  • pan locus tag?: SAUPAN005296000
  • symbol: SACOL2037
  • pan gene symbol?: —
  • synonym:
  • product: hypothetical protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SACOL2037 [new locus tag: SACOL_RS10635 ]
  • symbol: SACOL2037
  • product: hypothetical protein
  • replicon: chromosome
  • strand: +
  • coordinates: 2096287..2097897
  • length: 1611
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    ATGAGCACAAATCAAACATTTTTAATATTTGTTATAGCAATTATTCTACTTACATCTGTA
    ATAGGAATTGTTGGACGATACATGAGTCGTCAACGTCTATTAAAATCTATGGAAACATTA
    TGGCAAACGATTTCTCCATTAGAAGCTTTTATCAGACCGAACTCACATTTCGACTATGAG
    TATAAGCTCTACAAGGAAAAATTTGAATCACATTCATTAGTTGATGATAAAACTTGGTCC
    GACTTAAATATGAATGCAATCTTTCATAAGATGAATTATAATTTAACAGCTATTGGTGAA
    ATGAAGCTATATGCCTGTTTACGTGGAATGCTTTCAATTACGAACAAATCATTACTTAGT
    TTATTTAATGATAATGCTGAATTTAGAAAAAACGTAACATATCATTTAGCTTTGATTGGT
    AAAACTGTTTATCCAACATTTCCAGACCAAATCACACCGGTAAAACGTCAAAATATATTG
    TTTCTATGCCCGTTTTTACCAGTTATCTCATTTGCAGTTATATTTATTAATTCACAAGTT
    GGTATTTTATTATTTCTTATGAGTTGCCTATTTAATATCATTTTATCAGCAACTTTAAAG
    CGTACATATGAGGATGACTTAAAATCTATCTTTTATGCATCCAATGTTTTAAAACAAGGC
    TATACTATCTCAAAAATTAAACATGCTCCACAACCTGAAGTCAATTTTAAGCAATTTAGA
    ACAGCACGTCATTTAACGAGTGTTTTAGCTGAAGTTAATGATGAAGATATCGGAGCTATG
    GTAATTAAACTAGTTAAACTTATTTTCATGCTTGATTATGTTTTATTTCATTCAATTCAA
    AAAAGCTATACAACACATATGAATGAGCTTAAAAATTGTTTCGATTACATAGCTGAATTA
    GATAATCATTATGCATTAGCAATGTATCGTAGAACGCTAGAATGTTATACTGAACCACAA
    ATTGATGATTCAAATGATGGCATAGTATTCTCTGAGTTAACACATCCACTCATAGCAGAT
    GCAGTAGCCAATGATTTCTCACTATCACAAAATATACTGTTAACTGGGTCTAATGCTTCG
    GGTAAATCAACATTTATGAAATCCATAGCAATAAACATTATTCTTGCATCGGCTATACAA
    ACAGTTACCGCAAGCAAATTTGTATATCAACCTGGAATTGTGTTCACGTCAATGGCAAAT
    GCCGATGATGTGTTATCAGGCGATAGTTATTTTATGGCTGAATTAAAATCTATTAAGCGT
    ATTGTTGAAATTCCAGATAATCAAAAAATATACTGCTTTATAGATGAAATTTTTAAAGGT
    ACCAACACAACTGAACGAATTGCCGCTTCAGAATCAGTACTATCATTTTTACATGAAAAA
    TCTAACTTTAGAGTTATTGCAGCAACACATGATATTGAGTTAGCTGAACTCTTAAAACAA
    CGTTATGAAAATTACCATTTCAATGAGGTAATAGAAAATAATAACATACATTTTGATTAC
    AAAATTAAGCCTGGCAAAGCAAATACACGTAATGCCATCGAATTATTAAAAATCACTTCA
    TTTCCAGCAAAAATATATGAACGAGCAAAAGATAATGTCCCGAAAATTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1611

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SACOL2037 [new locus tag: SACOL_RS10635 ]
  • symbol: SACOL2037
  • description: hypothetical protein
  • length: 536
  • theoretical pI: 7.6459
  • theoretical MW: 61321.6
  • GRAVY: 0.0182836

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA mismatch repair protein MutS (TIGR01070; HMM-score: 120.7)
    and 4 more
    Genetic information processing DNA metabolism Other MutS2 family protein (TIGR01069; HMM-score: 59.9)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 13.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion protein EccCb (TIGR03925; HMM-score: 12.7)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 11.8)
  • TheSEED  :
    • MutS-related protein, family 1
    DNA Metabolism DNA repair DNA repair, bacterial MutL-MutS system  MutS-related protein, family 1
  • PFAM:
    P-loop_NTPase (CL0023) MutS_V; MutS domain V (PF00488; HMM-score: 104.3)
    and 10 more
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 20.4)
    AAA_14; AAA domain (PF13173; HMM-score: 20)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 19.4)
    G-alpha; G-protein alpha subunit (PF00503; HMM-score: 16.8)
    FtsK_SpoIIIE; FtsK/SpoIIIE family (PF01580; HMM-score: 15.4)
    ABC_tran; ABC transporter (PF00005; HMM-score: 14.7)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 13.1)
    AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 12.2)
    no clan defined Baculo_11_kDa; Baculovirus 11 kDa family (PF06143; HMM-score: 7.1)
    Sigma_reg_N; Sigma factor regulator N-terminal (PF13800; HMM-score: 6.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.07
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.18
    • Extracellular Score: 0.21
    • Internal Helices: 3
  • LocateP: Multi-transmembrane
    • Prediction by SwissProt Classification: Membrane
    • Pathway Prediction: Sec-(SPI)
    • Intracellular possibility: 0.17
    • Signal peptide possibility: -0.5
    • N-terminally Anchored Score: 1
    • Predicted Cleavage Site: No CleavageSite
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.087395
    • TAT(Tat/SPI): 0.001793
    • LIPO(Sec/SPII): 0.025101
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSTNQTFLIFVIAIILLTSVIGIVGRYMSRQRLLKSMETLWQTISPLEAFIRPNSHFDYEYKLYKEKFESHSLVDDKTWSDLNMNAIFHKMNYNLTAIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILFLCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFRTARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQIDDSNDGIVFSELTHPLIADAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTASKFVYQPGIVFTSMANADDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQRYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVPKI

⊟Experimental data[edit | edit source]

  • experimentally validated: PeptideAtlas
  • protein localization: Integral membrane [1] [2]
  • quantitative data / protein copy number per cell:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription pattern[edit | edit source]

⊟Protein synthesis (provided by Aureolib)[edit | edit source]

⊟Protein stability[edit | edit source]

  • half-life: no data available

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker
    A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
    PLoS One: 2009, 4(12);e8176
    [PubMed:19997597] [WorldCat.org] [DOI] (I e)
  2. ↑ Andreas Otto, Jan Maarten van Dijl, Michael Hecker, Dörte Becher
    The Staphylococcus aureus proteome.
    Int J Med Microbiol: 2014, 304(2);110-20
    [PubMed:24439828] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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