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NCBI: 02-MAR-2017

Summary[edit | edit source]

  • organism: Staphylococcus aureus COL
  • locus tag: SACOL_RS10060 [old locus tag: SACOL1924 ]
  • pan locus tag?: SAUPAN004847000
  • symbol: SACOL_RS10060
  • pan gene symbol?:
  • synonym:
  • product: multidrug ABC transporter ATP-binding protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SACOL_RS10060 [old locus tag: SACOL1924 ]
  • symbol: SACOL_RS10060
  • product: multidrug ABC transporter ATP-binding protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1987720..1989456
  • length: 1737
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_002951 (1987720..1989456) NCBI
  • BioCyc: G1G4B-2109 BioCyc
  • MicrobesOnline:

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGATTAAACGATATTTGCAATTTGTTAAGCCATACAAATATCGTATTTTTGCAACGATT
    ATTGTTGGGATAATTAAGTTTGGTATACCAATGCTTATACCACTATTAATTAAATATGCA
    ATAGATGGCGTGATTAATAACCACGCACTAACGACTGATGAAAAAGTTCATCATTTAACT
    ATTGCCATTGGTATCGCATTATTTATTTTTGTAATAGTGAGACCACCAATTGAATTTATA
    CGTCAATATTTGGCGCAATGGACAAGTAATAAAATATTGTATGATATACGTAAAAAGTTA
    TACAACCATTTACAAGCTTTAAGTGCGAGATTTTATGCTAATAATCAAGTAGGTCAAGTA
    ATATCTAGAGTGATTAATGATGTTGAACAAACAAAAGATTTCATTTTAACCGGGTTAATG
    AATATTTGGTTAGATTGTATAACAATTATTATTGCACTATCCATAATGTTCTTTTTAGAT
    GTGAAATTGACTTTAGCAGCACTGTTTATCTTCCCATTTTACATTTTAACGGTGTACGTT
    TTCTTTGGAAGATTAAGAAAATTGACACGTGAAAGATCTCAAGCATTAGCTGAGGTTCAA
    GGATTCTTGCATGAACGTGTTCAAGGTATTTCAGTCGTTAAAAGTTTTGCGATTGAAGAC
    AATGAAGCGAAAAACTTTGATAAAAAGAATACTAATTTCCTAACACGTGCGTTGAAACAT
    ACAAGATGGAATGCCTATTCCTTTGCCGCAATTAATACAGTTACAGATATTGGACCAATT
    ATTGTCATCGGTGTTGGTGCATATCTTGCTATTTCTGGATCAATCACAGTAGGTACACTT
    GCAGCATTTGTTGGATACTTAGAGTTATTGTTCGGGCCTTTACGTCGTTTAGTCGCATCA
    TTTACAACTTTAACGCAAAGTTTTGCTTCAATGGACCGTGTATTCCAATTAATTGATGAA
    GATTATGACATCAAAAATGGTGTTGGTGCTCAACCTATTGAAATTAAACAAGGTCGTATT
    GATATTGATCATGTTAGTTTTCAATATAACGATAACGAAGCTCCAATTTTAAAAGATATT
    AATTTGAGTATTGAAAAAGGAGAAACAGTTGCTTTCGTAGGTATGAGTGGTGGTGGTAAA
    TCAACATTAATTAACTTAATACCGAGATTTTACGATGTAACTTCTGGGCAAATTTTAATA
    GATGGTCACAACATTAAAGATTTTTTAACGGGAAGTTTAAGAAATCAAATAGGATTGGTG
    CAACAGGATAATATTTTATTCTCTGATACAGTTAAGGAAAATATTTTACTTGGTCGTCCA
    ACAGCAACAGATGAAGAAGTAGTTGAAGCGGCGAAAATGGCTAATGCACATGACTTTATT
    ATGAACTTGCCACAGGGATATGACACTGAAGTAGGTGAACGAGGTGTTAAATTATCAGGT
    GGTCAAAAACAAAGATTATCGATTGCTAGAATATTTTTAAATAATCCGCCAATTCTTATC
    TTGGATGAAGCAACAAGTGCACTTGATTTAGAAAGTGAATCCATTATTCAAGAAGCATTA
    GATGTGTTGAGTAAAGATCGAACGACACTTATCGTAGCGCATCGCTTGTCCACTATTACA
    CATGCTGACAAAATTGTCGTAATTGAAAATGGACATATTGTTGAAACAGGTACGCATCGT
    GAATTGATTGCAAAACAAGGTGCTTACGAGCATTTATATAGCATTCAAAACTTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1737

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SACOL_RS10060 [old locus tag: SACOL1924 ]
  • symbol: SACOL_RS10060
  • description: multidrug ABC transporter ATP-binding protein
  • length: 578
  • theoretical pI: 7.25358
  • theoretical MW: 64862.8
  • GRAVY: 0.196194

Function[edit | edit source]

  • reaction:
    EC 3.6.3.-?  ExPASy
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 517.4)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 517.4)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 487.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 450.1)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 427.5)
    and 73 more
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 357.4)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 357.4)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 355.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 355.7)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 341)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 341)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 341)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 326.2)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 313.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 313.1)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 313)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 277.1)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 250)
    Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 182.6)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 147.1)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 139.7)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 135.8)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 123.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 123.1)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 118.3)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 118.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 117.9)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 113.2)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 112.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 112.8)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 109.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 108.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 102.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 101.7)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 100.2)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 99.5)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 97)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 96.4)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 95.5)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 94.7)
    Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 94.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 92.9)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 92.9)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 91.3)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 90.2)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 90.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 90.1)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 85.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 84.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 83)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 83)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 82.5)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 81.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 80.7)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 80.2)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 75.7)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 75.1)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 75.1)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 72.9)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 70.4)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 68.9)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 67.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 66.9)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 66.9)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 66)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 60.7)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 56.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 54.1)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 49.2)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 40.8)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 37.1)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 13.7)
    Genetic information processing Protein synthesis Translation factors ribosome small subunit-dependent GTPase A (TIGR00157; EC 3.6.-.-; HMM-score: 13.4)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 13.4)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 12.5)
    rad50 (TIGR00606; HMM-score: 12.2)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 9.7)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 9.7)
  • TheSEED:
  • PFAM:
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 163)
    and 11 more
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 120.5)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 32.4)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 22.1)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 15.9)
    NTPase_1; NTPase (PF03266; HMM-score: 15)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 14.3)
    ABC_membrane (CL0241) ABC_membrane_3; ABC transporter transmembrane region (PF13748; HMM-score: 13.9)
    P-loop_NTPase (CL0023) AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 13.3)
    ABC_ATPase; Predicted ATPase of the ABC class (PF09818; HMM-score: 12.5)
    no clan defined Prp19; Prp19/Pso4-like (PF08606; HMM-score: 11.8)
    DUF2207; Predicted membrane protein (DUF2207) (PF09972; HMM-score: 5)

Structure, modifications & interactions[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • protein partners:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 6
  • LocateP:
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.013654
    • TAT(Tat/SPI): 0.000143
    • LIPO(Sec/SPII): 0.003511
  • predicted transmembrane helices (TMHMM): 5

Accession numbers[edit | edit source]

  • GI: 446519892 NCBI
  • RefSeq: WP_000597238 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MIKRYLQFVKPYKYRIFATIIVGIIKFGIPMLIPLLIKYAIDGVINNHALTTDEKVHHLTIAIGIALFIFVIVRPPIEFIRQYLAQWTSNKILYDIRKKLYNHLQALSARFYANNQVGQVISRVINDVEQTKDFILTGLMNIWLDCITIIIALSIMFFLDVKLTLAALFIFPFYILTVYVFFGRLRKLTRERSQALAEVQGFLHERVQGISVVKSFAIEDNEAKNFDKKNTNFLTRALKHTRWNAYSFAAINTVTDIGPIIVIGVGAYLAISGSITVGTLAAFVGYLELLFGPLRRLVASFTTLTQSFASMDRVFQLIDEDYDIKNGVGAQPIEIKQGRIDIDHVSFQYNDNEAPILKDINLSIEKGETVAFVGMSGGGKSTLINLIPRFYDVTSGQILIDGHNIKDFLTGSLRNQIGLVQQDNILFSDTVKENILLGRPTATDEEVVEAAKMANAHDFIMNLPQGYDTEVGERGVKLSGGQKQRLSIARIFLNNPPILILDEATSALDLESESIIQEALDVLSKDRTTLIVAHRLSTITHADKIVVIENGHIVETGTHRELIAKQGAYEHLYSIQNL

Experimental data[edit | edit source]

  • experimentally validated: no data available

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription pattern[edit | edit source]

Protein synthesis (provided by Aureolib)[edit | edit source]

Protein stability[edit | edit source]

  • half-life: no data available

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]