⊟Summary[edit | edit source]

pan ID^?: SAUPAN000024000
symbol^?: gdpP
synonym:
description^?: DHH family phosphoesterase
- DHH family phosphoesterase
- cyclic-di-AMP phosphodiesterase GdpP
- DHH family phosphoesterase, putative
- phosphoesterase, DHH family protein
- DHHA1 domain protein
- DHH family protein
- DHH subfamily 1 protein
- DHH subfamily phosphodiesterase
- phosphoesterase domain-containing protein
- putative bifunctional signaling protein/50S ribosomal protein L9
strand^?: +
coordinates^?: 24265..26250
synteny block^?: BlockID0000210
occurrence^?: in 100% of 33 strains

gdpP: cyclic-di-AMP phosphodiesterase^[1]

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_0014

08BA02176:

C248_0014

11819-97:

MS7_0014

6850:

RSAU_000014

71193:

ST398NM01_0014

ECT-R 2:

ECTR2_14

ED133:

SAOV_0014

ED98:

SAAV_0016

HO 5096 0412:

SAEMRSA15_00140

JH1:

SaurJH1_0014

JH9:

SaurJH9_0014

JKD6008:

SAA6008_00014

JKD6159:

SAA6159_00014

LGA251:

SARLGA251_00140

M013:

M013TW_0015

MRSA252:

SAR0014

MSHR1132:

SAMSHR1132_00140

MSSA476:

SAS0014

Mu3:

SAHV_0014

Mu50:

SAV0014

MW2:

MW0014

RF122:

SAB0014

ST398:

SAPIG0014

T0131:

SAT0131_00016

TCH60:

HMPREF0772_10454

TW20:

SATW20_00140

USA300_TCH1516:

USA300HOU_0014

VC40:

SAVC_00070

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MNRQSTKKALLIPFVIMIITAIVLMGVWFIFNSLIALIASIVLVVMIIVSIILFRQALMK
N315            MNRQSTKKALLIPFVIMIITAIVLMGVWFIFNSLIALIASIVLVVMIIVSIILFRQALMK
NCTC8325        MNRQSTKKALLIPFVIMIITAIVLMGVWFIFNSLIALIASIVLVVMIIVSIILFRQALMK
Newman          MNRQSTKKALLIPFVIMIITAIVLMGVWFIFNSLIALIASIVLVVMIIVSIILFRQALMK
USA300_FPR3757  MNRQSTKKALLIPFVIMIITAIVLMGVWFIFNSLIALIASIVLVVMIIVSIILFRQALMK
                ************************************************************

COL             MDSYVDGLSAQISTTNNKAIKHLPIGIIVLDENDHIEWVNQFMTDHMEANVISESVNEVF
N315            MDSYVDGLSAQISTTNNKAIKHLPIGIIVLDENDHIEWVNQFMTNHMEANVISESVNEVF
NCTC8325        MDSYVDGLSAQISTTNNKAIKHLPIGIIVLDENDHIEWVNQFMTDHMEANVISESVNEVF
Newman          MDSYVDGLSAQISTTNNKAIKHLPIGIIVLDENDHIEWVNQFMTDHMEANVISESVNEVF
USA300_FPR3757  MDSYVDGLSAQISTTNNKAIKHLPIGIIVLDENDHIEWVNQFMTDHMEANVISESVNEVF
                ********************************************:***************

COL             PNILKQLDRVKSVEIEYNQYHFQVRYSENDHCLYFFDITEQVQTNELYENSKPIIATLFL
N315            PNILKQLDRVKSVEIEYNQYHFQVRYSENDHCLYFFDITEQVQTNELYENSKPIIATLFL
NCTC8325        PNILKQLDRVKSVEIEYNQYHFQVRYSENDHCLYFFDITEQVQTNELYENSKPIIATLFL
Newman          PNILKQLDRVKSVEIEYNQYHFQVRYSENDHCLYFFDITEQVQTNELYENSKPIIATLFL
USA300_FPR3757  PNILKQLDRVKSVEIEYNQYHFQVRYSENDHCLYFFDITEQVQTNELYENSKPIIATLFL
                ************************************************************

COL             DNYDEITQNMNDTQRSEINSMVTRVISRWATEYNIFFKRYSSDQFVAYLNQKILADLEES
N315            DNYDEITQNMNDTQRSEINSMVTRVISRWATEYNIFFKRYSSDQFVAYLNQKILADLEES
NCTC8325        DNYDEITQNMNDTQRSEINSMVTRVISRWATEYNIFFKRYSSDQFVAYLNQKILADLEES
Newman          DNYDEITQNMNDTQRSEINSMVTRVISRWATEYNIFFKRYSSDQFVAYLNQKILADLEES
USA300_FPR3757  DNYDEITQNMNDTQRSEINSMVTRVISRWATEYNIFFKRYSSDQFVAYLNQKILADLEES
                ************************************************************

COL             KFDILSQLREKSVGYRAQLTLSIGVGEGTENLIDLGELSQSGLDLALGRGGDQVAIKSIN
N315            KFDILSQLREKSVGYRAQLTLSIGVGEGTENLIDLGELSQSGLDLALGRGGDQVAIKSIN
NCTC8325        KFDILSQLREKSVGYRAQLTLSIGVGEGTENLIDLGELSQSGLDLALGRGGDQVAIKSIN
Newman          KFDILSQLREKSVGYRAQLTLSIGVGEGTENLIDLGELSQSGLDLALGRGGDQVAIKSIN
USA300_FPR3757  KFDILSQLREKSVGYRAQLTLSIGVGEGTENLIDLGELSQSGLDLALGRGGDQVAIKSIN
                ************************************************************

COL             GNVRFYGGKTDPMEKRTRVRARVISHALKDILAEGDKVIIMGHKRPDLDAIGAAIGVSRF
N315            GNVRFYGGKTDPMEKRTRVRARVISHALKDILAEGDKVIIMGHKRPDLDAIGAAIGVSRF
NCTC8325        GNVRFYGGKTDPMEKRTRVRARVISHALKDILAEGDKVIIMGHKRPDLDAIGAAIGVSRF
Newman          GNVRFYGGKTDPMEKRTRVRARVISHALKDILAEGDKVIIMGHKRPDLDAIGAAIGVSRF
USA300_FPR3757  GNVRFYGGKTDPMEKRTRVRARVISHALKDILAEGDKVIIMGHKRPDLDAIGAAIGVSRF
                ************************************************************

COL             AMMNNLEAYIVLNETDIDPTLRRVMNEIDKKPELRERFITSDDAWDMMTSKTTVVIVDTH
N315            AMMNNLEAYIVLNETDIDPTLRRVMNEIDKKSELRERFITSDDAWDMMTSKTTVVIVDTH
NCTC8325        AMMNNLEAYIVLNETDIDPTLRRVMNEIDKKPELRERFITSDDAWDMMTSKTTVVIVDTH
Newman          AMMNNLEAYIVLNETDIDPTLRRVMNEIDKKPELRERFITSDDAWDMMTSKTTVVIVDTH
USA300_FPR3757  AMMNNLEAYIVLNETDIDPTLRRVMNEIDKKPELRERFITSDDAWDMMTSKTTVVIVDTH
                *******************************.****************************

COL             KPELVLDENVLNKANRKVVIDHHRRGESFISNPLLIYMEPYASSTAELVTELLEYQPTEQ
N315            KPELVLDENVLNKANRKVVIDHHRRGESFISNPLLIYMEPYASSTAELVTELLEYQPTEQ
NCTC8325        KPELVLDENVLNKANRKVVIDHHRRGESFISNPLLIYMEPYASSTAELVTELLEYQPTEQ
Newman          KPELVLDENVLNKANRKVVIDHHRRGESFISNPLLIYMEPYASSTAELVTELLEYQPTEQ
USA300_FPR3757  KPELVLDENVLNKANRKVVIDHHRRGESFISNPLLIYMEPYASSTAELVTELLEYQPTEQ
                ************************************************************

COL             RLTRLESTVMYAGIIVDTRNFTLRTGSRTFDAASYLRAHGADTILTQHFLKDDVDTYINR
N315            RLTRLESTVMYAGIIVDTRNFTLRTGSRTFDAASYLRAHGADTILTQHFLKDDVDTYINR
NCTC8325        RLTRLESTVMYAGIIVDTRNFTLRTGSRTFDAASYLRAHGADTILTQHFLKDDVDTYINR
Newman          RLTRLESTVMYAGIIVDTRNFTLRTGSRTFDAASYLRAHGADTILTQHFLKDDVDTYINR
USA300_FPR3757  RLTRLESTVMYAGIIVDTRNFTLRTGSRTFDAASYLRAHGADTILTQHFLKDDVDTYINR
                ************************************************************

COL             SELIRTVKVEDNGIAIAHGSDDKIYHPVTVAQAADELLSLEGIEASYVVARREDNLIGIS
N315            SELIRTVKVEDNGIAIAHGSDDKIYHPVTVAQAADELLSLEGIEASYVVARREDNLIGIS
NCTC8325        SELIRTVKVEDNGIAIAHGSDDKIYHPVTVAQAADELLSLEGIEASYVVARREDNLIGIS
Newman          SELIRTVKVEDNGIAIAHGSDDKIYHPVTVAQAADELLSLEGIEASYVVARREDNLIGIS
USA300_FPR3757  SELIRTVKVEDNGIAIAHGSDDKIYHPVTVAQAADELLSLEGIEASYVVARREDNLIGIS
                ************************************************************

COL             ARSLGSVNVQLTMEALGGGGHLTNAATQLKGVTVEEAIAQLQQAITEQLSRSEDA
N315            ARSLGSVNVQLTMEALGGGGHLTNAATQLKGVTVEEAIAQLQQAITEQLSRSEDA
NCTC8325        ARSLGSVNVQLTMEALGGGGHLTNAATQLKGVTVEEAIAQLQQAITEQLSRSEDA
Newman          ARSLGSVNVQLTMEALGGGGHLTNAATQLKGVTVEEAIAQLQQAITEQLSRSEDA
USA300_FPR3757  ARSLGSVNVQLTMEALGGGGHLTNAATQLKGVTVEEAIAQLQQAITEQLSRSEDA
                *******************************************************

↑ Raymond Poon, Li Basuino, Nidhi Satishkumar, Aditi Chatterjee, Nagaraja Mukkayyan, Emma Buggeln, Liusheng Huang, Vinod Nair, Maria A Argudín, Sandip K Datta, Henry F Chambers, Som S Chatterjee
Loss of GdpP Function in Staphylococcus aureus Leads to β-Lactam Tolerance and Enhanced Evolution of β-Lactam Resistance.
Antimicrob Agents Chemother: 2022, 66(2);e0143121
[PubMed:34843389] [WorldCat.org] [DOI] (I p)

[1] Raymond Poon, Li Basuino, Nidhi Satishkumar, Aditi Chatterjee, Nagaraja Mukkayyan, Emma Buggeln, Liusheng Huang, Vinod Nair, Maria A Argudín, Sandip K Datta, Henry F Chambers, Som S Chatterjee
Loss of GdpP Function in Staphylococcus aureus Leads to β-Lactam Tolerance and Enhanced Evolution of β-Lactam Resistance.
Antimicrob Agents Chemother: 2022, 66(2);e0143121
[PubMed:34843389] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]