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PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN000807000
- symbol?: speG
- synonym:
- description?: spermidine N(1)-acetyltransferase
- spermidine N(1)-acetyltransferase
- spermidine N1-acetyltransferase
- diamine N-acetyltransferase
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 1039119..1039616
- synteny block?: BlockID0003910
- occurrence?: in 6% of 34 strains
speG : arginine catabolic mobile element spermidine N(1)-acetyltransferase [1]
• this polyamine acetyltransferase is found in the Arginine Catabolic Mobile Element (ACME) that is sometimes found alongside the SCCmec cassette, particularly in USA300 MRSA strains. It is a key factor in the success of the lineage, enhancing biofilm potential, reducing host-mediated killing, and detoxifying host polyamines, facilitating skin colonization.
A crystal structure of SpeG is available : 8FV0
⊟Orthologs[edit | edit source]
COL:
—
N315:
—
NCTC8325:
—
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
—
JH1:
—
JH9:
—
JKD6008:
—
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0057
VC40:
—
⊟Genome Viewer[edit | edit source]
⊟Alignments[edit | edit source]
- alignment of orthologues:
- ↑ Gauri S Joshi, Jeffrey S Spontak, David G Klapper, Anthony R Richardson
Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines.
Mol Microbiol: 2011, 82(1);9-20
[PubMed:21902734] [WorldCat.org] [DOI] (I p)Paul J Planet, Samuel J LaRussa, Ali Dana, Hannah Smith, Amy Xu, Chanelle Ryan, Anne-Catrin Uhlemann, Sam Boundy, Julia Goldberg, Apurva Narechania, Ritwij Kulkarni, Adam J Ratner, Joan A Geoghegan, Sergios-Orestis Kolokotronis, Alice Prince
Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and speG-mediated adaptations for survival on skin.
mBio: 2013, 4(6);e00889-13
[PubMed:24345744] [WorldCat.org] [DOI] (I e)Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Mina Hirose, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi
Clonal diversity of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections in northern Japan: Identification of spermidine N-acetyltransferase gene (speG) in staphylococcal cassette chromosomes (SCCs) associated with type II and IV SCCmec.
J Glob Antimicrob Resist: 2021, 24;207-214
[PubMed:33373735] [WorldCat.org] [DOI] (I p)Sofiya Tsimbalyuk, Aleksander Shornikov, Parul Srivastava, Van Thi Bich Le, Imani Warren, Yogesh B Khandokar, Misty L Kuhn, Jade K Forwood
Structural and Kinetic Characterization of the SpeG Spermidine/Spermine N-acetyltransferase from Methicillin-Resistant Staphylococcus aureus USA300.
Cells: 2023, 12(14);
[PubMed:37508494] [WorldCat.org] [DOI] (I e)