⊟Summary[edit | edit source]

pan ID^?: SAUPAN001036000
symbol^?: murR
synonym:
description^?: MurR/RpiR family transcriptional regulator
- MurR/RpiR family transcriptional regulator
- transcriptional regulator
- putative transcriptional regulator RpiR family
- RpiR family phosphosugar-binding transcriptional regulator
- helix-turn-helix domain, rpiR family protein
- phosphosugar-binding transcriptional regulator, RpiR family
- RpiR family transcripitonal regulator
- RpiR family transcriptional regulator
- RpiR family transcription regulator
- Sialic acid utilization regulator, RpiR family
- Transcriptional regulator, RpiR family
- transcription regulator RpiR family
strand^?: +
coordinates^?: 1311372..1312250
synteny block^?: BlockID0005630
occurrence^?: in 100% of 33 strains

murR: MurNAc-GlcNAc turnover transcriptional repressor MurR ^[1]

• "MurNAc-GlcNAc" also called "N-acetylmuramate" refers to the disaccharide N-acetylmuramic acid-β-1,4-N-acetylglucosamine

• MurR has a consensus DNA binding motif of: 5'-ATTGTAAwnnnwTTACAAT-3'

• The MurR Regulon consists of Four Genes

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_0194

08BA02176:

C248_0185

11819-97:

MS7_0186

6850:

RSAU_000145

71193:

ST398NM01_0211

ECT-R 2:

ECTR2_156

ED133:

SAOV_0138

ED98:

SAAV_0162

HO 5096 0412:

SAEMRSA15_01580

JH1:

SaurJH1_0183

JH9:

SaurJH9_0178

JKD6008:

SAA6008_00172

JKD6159:

SAA6159_00175

LGA251:

SARLGA251_01640

M013:

M013TW_0181

MRSA252:

SAR0194

MSHR1132:

SAMSHR1132_01680

MSSA476:

SAS0168

Mu3:

SAHV_0192

Mu50:

SAV0193

MW2:

MW0167

RF122:

SAB0133

ST398:

SAPIG0211

T0131:

SAT0131_00188

TCH60:

HMPREF0772_10305

TW20:

SATW20_02030

USA300_TCH1516:

USA300HOU_0207

VC40:

SAVC_00735

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             -MTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKM
N315            -MTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKM
NCTC8325        -MTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKM
Newman          MMTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKM
USA300_FPR3757  -MTNILYRIDKQLSDFTKTEKIIADYILKNPHKIIDMTVNDLADVTNVSTASIVRFSRKM
                 ***********************************************************

COL             THQGFQELKIAISRYLPEDIATNPHLELIENESVETLKNKMIARATNTMRFVATNIMDAQ
N315            THQGFQELKIAISRYLPEDIATNPHLELIENESVETLKNKMIARATNTMRFVATNIMDAQ
NCTC8325        THQGFQELKIAISRYLPEDIATNPHLELIENESVETLKNKMIARATNTMRFVATNIMDAQ
Newman          THQGFQELKIAISRYLPEDIATNPHLELIENESVETLKNKMIARATNTMRFVATNIMDAQ
USA300_FPR3757  THQGFQELKIAISRYLPEDIATNPHLELIENESVETLKNKMIARATNTMRFVATNIMDAQ
                ************************************************************

COL             IDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRD
N315            IDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRD
NCTC8325        IDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRD
Newman          IDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRD
USA300_FPR3757  IDAICDVLKNARTIFLFGFGASSLTIGDLFQKLSRIGLNVRLLHETHLLVSTFATHDDRD
                ************************************************************

COL             CMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENEMRMA
N315            CMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENEMRMA
NCTC8325        CMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENEMRMA
Newman          CMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENEMRMA
USA300_FPR3757  CMIFVTNQGSHSELQSIAQVATHYSIPIITISSTANNPVAQIADYALIYGRTDENEMRMA
                ************************************************************

COL             ATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKMALDNYRKHLATIDFKH
N315            ATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKMALDNYRKHLATIDFKH
NCTC8325        ATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKMALDNYRKHLATIDFKH
Newman          ATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKMALDNYRKHLATIDFKH
USA300_FPR3757  ATTSLFAQLFTVDILYYRFVALNYHAILDCITQSKMALDNYRKHLATIDFKH
                ****************************************************

↑ Robert Maria Kluj, Patrick Ebner, Martina Adamek, Nadine Ziemert, Christoph Mayer, Marina Borisova
Recovery of the Peptidoglycan Turnover Product Released by the Autolysin Atl in Staphylococcus aureus Involves the Phosphotransferase System Transporter MurP and the Novel 6-phospho-N-acetylmuramidase MupG.
Front Microbiol: 2018, 9;2725
[PubMed:30524387] [WorldCat.org] [DOI] (P e)Yefei Zhu, Renu Nandakumar, Marat R Sadykov, Nandakumar Madayiputhiya, Thanh T Luong, Rosmarie Gaupp, Chia Y Lee, Greg A Somerville
RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation.
J Bacteriol: 2011, 193(22);6187-96
[PubMed:21926234] [WorldCat.org] [DOI] (I p)

[1] Robert Maria Kluj, Patrick Ebner, Martina Adamek, Nadine Ziemert, Christoph Mayer, Marina Borisova
Recovery of the Peptidoglycan Turnover Product Released by the Autolysin Atl in Staphylococcus aureus Involves the Phosphotransferase System Transporter MurP and the Novel 6-phospho-N-acetylmuramidase MupG.
Front Microbiol: 2018, 9;2725
[PubMed:30524387] [WorldCat.org] [DOI] (P e)Yefei Zhu, Renu Nandakumar, Marat R Sadykov, Nandakumar Madayiputhiya, Thanh T Luong, Rosmarie Gaupp, Chia Y Lee, Greg A Somerville
RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation.
J Bacteriol: 2011, 193(22);6187-96
[PubMed:21926234] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]