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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001177000
- symbol?: essA
- synonym:
- description?: protein EssA
- protein EssA
- type VII secretion protein EssA
- Putative secretion system component EssA
- Virulence Protein essA
- protein EssA (Precursor)
- protein secretion system EssA
- pseudogene
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1446675..1447133
- synteny block?: BlockID0006960
- occurrence?: in 100% of 34 strains
essA : type VIIb/ESAT-6 secretion translocon structural component EssA [1]
• Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0284 (essA)
08BA02176:
C248_0274 (essA)
11819-97:
MS7_0275 (essA)
6850:
RSAU_000230 (essA)
71193:
ST398NM01_0299
ECT-R 2:
ECTR2_245
ED133:
SAOV_0227
ED98:
SAAV_0252
HO 5096 0412:
SAEMRSA15_02430
JH1:
SaurJH1_0275
JH9:
SaurJH9_0268
JKD6008:
SAA6008_00258 (essA)
JKD6159:
SAA6159_00265 (essA)
JSNZ:
JSNZ_000228 (essA)
LGA251:
SARLGA251_02480 (essA)
M013:
M013TW_0265
MRSA252:
SAR0281
MSHR1132:
SAMSHR1132_02520
MSSA476:
SAS0260
Mu3:
SAHV_0282
Mu50:
SAV0284
MW2:
MW0260
RF122:
SAB0225
ST398:
SAPIG0299
T0131:
SAT0131_00280
TCH60:
HMPREF0772_10216 (essA)
TW20:
SATW20_02860 (essA)
USA300_TCH1516:
USA300HOU_0299 (essA)
VC40:
SAVC_01170
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKAVNDAIAKQK
N315 MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKEVNDAIAKQK
NCTC8325 MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKAVNDAIAKQK
Newman MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKAVNDAIAKQK
USA300_FPR3757 MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKAVNDAIAKQK
************************************************** *********
COL KERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYIL
N315 KERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYIL
NCTC8325 KERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYIL
Newman KERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYIL
USA300_FPR3757 KERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYIL
************************************************************
COL MSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
N315 MSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
NCTC8325 MSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
Newman MSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
USA300_FPR3757 MSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
********************************
- ↑ Maksym Bobrovskyy, So Young Oh, Dominique Missiakas
Contribution of the EssC ATPase to the assembly of the type 7b secretion system in Staphylococcus aureus.
J Biol Chem: 2022, 298(9);102318
[PubMed:35921891] [WorldCat.org] [DOI] (I p)Franziska Jäger, Martin Zoltner, Holger Kneuper, William N Hunter, Tracy Palmer
Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus.
FEBS Lett: 2016, 590(3);349-57
[PubMed:26785823] [WorldCat.org] [DOI] (I p)