Jump to navigation
Jump to search
⊟Summary[edit | edit source]
- pan ID?: SAUPAN001185000
- symbol?: esxC
- synonym:
- description?: protein EsaC
- protein EsaC
- type VII secretion substrate EsaC
- virulence protein EsaC
- EsaC protein within ESAT-6 gene cluster
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1456464..1456856
- synteny block?: BlockID0007040
- occurrence?: in 68% of 34 strains
esxC : type VIIb/ESAT-6 secretion cargo stabilization complex component EsxC [1]
• Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0288 (esaC)
08BA02176:
—
11819-97:
MS7_0279 (esaC)
6850:
RSAU_000234 (esaC)
71193:
—
ECT-R 2:
ECTR2_249
ED133:
SAOV_0231
ED98:
SAAV_0256
HO 5096 0412:
—
JH1:
SaurJH1_0279
JH9:
SaurJH9_0272
JKD6008:
—
JKD6159:
SAA6159_00269 (esaC)
JSNZ:
JSNZ_000232 (esaC)
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
SAMSHR1132_02560
MSSA476:
SAS0264
Mu3:
SAHV_0286
Mu50:
SAV0289
MW2:
MW0264
RF122:
SAB0229
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0303 (esaC)
VC40:
SAVC_01195
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNFNDIETMVKSKFKDIKKHAEEIAHEIEVRSGYLRKAEQYKRLEFNLSFALDDIESTAK
N315 MNFNDIETMVKSKFKDIKKHAEEIAHEIEVRSGYLRKAEQYKRLEFNLSIALDDVESTAK
NCTC8325 MNFNDIETMVKSKFKDIKKHAEEIAHEIEVRSGYLRKAEQYKRLEFNLSFALDDIESTAK
Newman MNFNDIETMVKSKFKDIKKHAEEIAHEIEVRSGYLRKAEQYKRLEFNLSFALDDIESTAK
USA300_FPR3757 MNFNDIETMVKSKFKDIKKHAEEIAHEIEVRSGYLRKAEQYKRLEFNLSFALDDIESTAK
*************************************************:****:*****
COL DVQTAKSSANKDSVTVKGKAPNTLYIEKRNLMKQKLEMLGEDIDKNKESLQKAKEIAGEK
N315 DVQTAKSSANKDSVSVKGKAPNTLYIEKRNLMKQKLEMLGEDIDKNKESLQKAKGIAGEK
NCTC8325 DVQTAKSSANKDSVTVKGKAPNTLYIEKRNLMKQKLEMLGEDIDKNKESLQKAKEIAGEK
Newman DVQTAKSSANKDSVTVKGKAPNTLYIEKRNLMKQKLEMLGEDIDKNKESLQKAKEIAGEK
USA300_FPR3757 DVQTAKSSANKDSVTVKGKAPNTLYIEKRNLMKQKLEMLGEDIDKNKESLQKAKEIAGEK
**************:*************************************** *****
COL ASEYFNKAMN
N315 ASEYFNKAMN
NCTC8325 ASEYFNKAMN
Newman ASEYFNKAMN
USA300_FPR3757 ASEYFNKAMN
**********
- ↑ Yaping Yang, Eleanor Boardman, Justin Deme, Felicity Alcock, Susan Lea, Tracy Palmer
Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease.
mBio: 2023, 14(5);e0210023
[PubMed:37815362] [WorldCat.org] [DOI] (I p)Rofida M Abd El-Fatah, Noha M Mesbah, Dina M Abo-Elmatty, Khaled A Aly
The C-terminus of the ESAT6-like secretion system virulence factor EsxC mediates divalent cation-dependent homodimerization.
Toxicon: 2018, 146;129-137
[PubMed:29499245] [WorldCat.org] [DOI] (I p)