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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001186000
- symbol?: esxB
- synonym:
- description?: virulence factor EsxB
- virulence factor EsxB
- WXG100 family type VII secretion effector EsxB
- virulence protein EsxB
- ESAT-6/Esx family secreted protein EsxB
- virulence factor EsxB family protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 1456872..1457251
- synteny block?: BlockID0007040
- occurrence?: in 68% of 34 strains
esxB : type VIIb/ESAT-6 secretion cargo stabilization and transolocon recruitment component EsxB [1]
• Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0289 (esxB)
08BA02176:
—
11819-97:
MS7_0280
6850:
RSAU_000235 (esxB)
71193:
—
ECT-R 2:
ECTR2_250
ED133:
SAOV_0232
ED98:
SAAV_0257
HO 5096 0412:
—
JH1:
SaurJH1_0280
JH9:
SaurJH9_0273
JKD6008:
—
JKD6159:
SAA6159_00270 (esxB)
JSNZ:
JSNZ_000233 (esxB)
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
SAMSHR1132_02570
MSSA476:
SAS0265
Mu3:
SAHV_0287
Mu50:
SAV0290
MW2:
MW0265
RF122:
SAB0230
ST398:
—
T0131:
—
TCH60:
—
TW20:
—
USA300_TCH1516:
USA300HOU_0304 (esxB)
VC40:
SAVC_01200
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
N315 MGGYKGIKADGGKVNQAKQLAAKIAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
NCTC8325 MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
Newman MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
USA300_FPR3757 MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
**************:******** ************************************
COL IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
N315 IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
NCTC8325 IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
Newman IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
USA300_FPR3757 IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
********************************************
- ↑ Yaping Yang, Eleanor Boardman, Justin Deme, Felicity Alcock, Susan Lea, Tracy Palmer
Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease.
mBio: 2023, 14(5);e0210023
[PubMed:37815362] [WorldCat.org] [DOI] (I p)Nicole Mietrach, Diana Damián-Aparicio, Benjamin Mielich-Süss, Daniel Lopez, Sebastian Geibel
Substrate Interaction with the EssC Coupling Protein of the Type VIIb Secretion System.
J Bacteriol: 2020, 202(7);
[PubMed:31964696] [WorldCat.org] [DOI] (I e)Lin Gao, Tian Tian, Tingrong Xiong, Xiaomei Zhang, Ning Wang, Luxuan Liu, Yun Shi, Qiang Liu, Dongshui Lu, Ping Luo, Weijun Zhang, Ping Cheng, Qiang Gou, Yu Wang, Hao Zeng, Xiaokai Zhang, Quanming Zou
Type VII secretion system extracellular protein B targets STING to evade host anti-Staphylococcus aureus immunity.
Proc Natl Acad Sci U S A: 2024, 121(22);e2402764121
[PubMed:38771879] [WorldCat.org] [DOI] (I p)