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Summary[edit | edit source]

  • pan ID?: SAUPAN001186000
  • symbol?: esxB
  • synonym:
  • description?: virulence factor EsxB

      descriptions from strain specific annotations:

    • virulence factor EsxB
    • WXG100 family type VII secretion effector EsxB
    • virulence protein EsxB
    • ESAT-6/Esx family secreted protein EsxB
    • virulence factor EsxB family protein
  • strand?: +
  • coordinates?: 1456872..1457251
  • synteny block?: BlockID0007040
  • occurrence?: in 68% of 34 strains

esxB : type VIIb/ESAT-6 secretion cargo stabilization and transolocon recruitment component EsxB [1]

Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0289 (esxB)
    08BA02176:
    11819-97:
    MS7_0280
    6850:
    RSAU_000235 (esxB)
    71193:
    ECT-R 2:
    ECTR2_250
    ED133:
    SAOV_0232
    ED98:
    SAAV_0257
    HO 5096 0412:
    JH1:
    SaurJH1_0280
    JH9:
    SaurJH9_0273
    JKD6008:
    JKD6159:
    SAA6159_00270 (esxB)
    JSNZ:
    JSNZ_000233 (esxB)
    LGA251:
    M013:
    MRSA252:
    MSHR1132:
    SAMSHR1132_02570
    MSSA476:
    SAS0265
    Mu3:
    SAHV_0287
    Mu50:
    SAV0290
    MW2:
    MW0265
    RF122:
    SAB0230
    ST398:
    T0131:
    TCH60:
    TW20:
    USA300_TCH1516:
    USA300HOU_0304 (esxB)
    VC40:
    SAVC_01200

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
    N315            MGGYKGIKADGGKVNQAKQLAAKIAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
    NCTC8325        MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
    Newman          MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
    USA300_FPR3757  MGGYKGIKADGGKVDQAKQLAAKTAKDIEACQKQTQQLAEYIEGSDWEGQFANKVKDVLL
                    **************:******** ************************************

    COL             IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
    N315            IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
    NCTC8325        IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
    Newman          IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
    USA300_FPR3757  IMAKFQEELVQPMADHQKAIDNLSQNLAKYDTLSIKQGLDRVNP
                    ********************************************

  1. Yaping Yang, Eleanor Boardman, Justin Deme, Felicity Alcock, Susan Lea, Tracy Palmer
    Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease.
    mBio: 2023, 14(5);e0210023
    [PubMed:37815362] [WorldCat.org] [DOI] (I p)
    Nicole Mietrach, Diana Damián-Aparicio, Benjamin Mielich-Süss, Daniel Lopez, Sebastian Geibel
    Substrate Interaction with the EssC Coupling Protein of the Type VIIb Secretion System.
    J Bacteriol: 2020, 202(7);
    [PubMed:31964696] [WorldCat.org] [DOI] (I e)
    Lin Gao, Tian Tian, Tingrong Xiong, Xiaomei Zhang, Ning Wang, Luxuan Liu, Yun Shi, Qiang Liu, Dongshui Lu, Ping Luo, Weijun Zhang, Ping Cheng, Qiang Gou, Yu Wang, Hao Zeng, Xiaokai Zhang, Quanming Zou
    Type VII secretion system extracellular protein B targets STING to evade host anti-Staphylococcus aureus immunity.
    Proc Natl Acad Sci U S A: 2024, 121(22);e2402764121
    [PubMed:38771879] [WorldCat.org] [DOI] (I p)