PangenomeCOLN315NCTC8325NewmanUSA300_FPR3757JSNZ04-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

⊟Summary[edit | edit source]

pan ID^?: SAUPAN001190000
symbol^?: esaD
synonym:
description^?: DNA/RNA non-specific endonuclease
- DNA/RNA non-specific endonuclease
- ribonuclease YeeF family protein
- transposase
- pseudogene
- yeeF
strand^?: +
coordinates^?: 1459692..1470003
synteny block^?: BlockID0007060
occurrence^?: in 62% of 34 strains

essD (esaD) : type VIIb-secreted virulence factor EssD endonuclease ^[1]

• A crystal structure is available : 8GUO

• Staphylococcus aureus encodes a toxin secretion system called either the "Type VIIb Secretion" or "ESAT-6" pathway. EsxBCD surround the toxin "cargo" and the Esx-cargo complex is loaded onto a "translocon" system for transport across the staphylococcal membrane. A dedicated peptidoglycan amidase/endopeptidase (EssH) hydrolyzes the cell wall to allow translocated (exported) cargo access to the extracellular environment.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

JSNZ:

04-02981:

SA2981_0292

08BA02176:

—

11819-97:

MS7_0283

6850:

RSAU_000238

71193:

—

ECT-R 2:

ECTR2_253

ED133:

SAOV_0235

ED98:

SAAV_0260

HO 5096 0412:

—

JH1:

SaurJH1_0283

JH9:

SaurJH9_0276

JKD6008:

—

JKD6159:

—

LGA251:

—

M013:

—

MRSA252:

—

MSHR1132:

—

MSSA476:

SAS0268

Mu3:

SAHV_0290

Mu50:

SAV0293

MW2:

MW0268

RF122:

SAB0233

ST398:

—

T0131:

—

TCH60:

—

TW20:

—

USA300_TCH1516:

USA300HOU_0307

VC40:

SAVC_01215

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.505)

COL             ---MTKDIEYLTADYDNEKSSIQSVIDAIEGQDFLDVDTTMDDAVSDVSSLDEDGAISLT
N315            ---MTKDIEYLTADYDNEKSSIQSVIDAIEGQDFLDVDTTMDDAVSDVSSLDEDGAISLT
NCTC8325        ---MTKDIEYLTADYDNEKSSIQSVIDAIEGQDFLDVDTTMDDAVSDVSSLDEDGAISLT
Newman          MHDMTKDIEYLTADYDNEKSSIQSVIDAIEGQDFLDVDTTMDDAVSDVSSLDEDGAISLT
USA300_FPR3757  ---MTKDIEYLTADYDNEKSSIQSVIDAIEGQDFLDVDTTMDDAVSDVSSLDEDGAISLT
JSNZ            ---MTKDIEYLTADYDNEKSSIQSVIDAIEGQDFLDVDTTMDDAVSDVSSLDEDGAISLT
                   *********************************************************

COL             SSVVGPQGSKLMGYYQNELYDYASQLDSKMKEIIDTPFIEDIDKAFKGITNVKLENILIK
N315            SSVVGPQGSKLMGYYQNELYDYASQLDSKMKEIIDTPFIEDIDKAFKGITNVKLENILIK
NCTC8325        SSVVGPQGSKLMGYYQNELYDYASQLDSKMKEIIDTPFIEDIDKAFKGITNVKLENILIK
Newman          SSVVGPQGSKLMGYYQNELYDYASQLDSKMKEIIDTPFIEDIDKAFKGITNVKLENILIK
USA300_FPR3757  SSVVGPQGSKLMGYYQNELYDYASQLDSKMKEIIDTPFIEDIDKAFKGITNVKLENILIK
JSNZ            SSVVGPQGSKLMGYYQNELYDYASQLDSKMKEIIDTPFIEDIDKAFKGITNVKLENILIK
                ************************************************************

COL             NGGGHGRDTYGASGKIAKGDAKKSDSDVYSIDEILKSDQEFVKVIDQHYKEMKKEDKKLS
N315            NGGGHGRDTYGASGKIAKGDAKKSDSDVYSIDEILKSDQEFVKVIDQHYKEMKKEDKKLS
NCTC8325        NGGGHGRDTYGASGKIAKGDAKKSDSDVYSIDEILKSDQEFVKVIDQHYKEMKKEDKKLS
Newman          NGGGHGRDTYGASGKIAKGDAKKSDSDVYSIDEILKSDQEFVKVIDQHYKEMKKEDKKLS
USA300_FPR3757  NGGGHGRDTYGASGKIAKGDAKKSDSDVYSIDEILKSDQEFVKVIDQHYKEMKKEDKKLS
JSNZ            NGGGHGRDTYGASGKIAKGDAKKSDSDVYSIDEILKSDQEFVKVIDQHYKEMKKEDKKLS
                ************************************************************

COL             KSDFEKMMTQGASCDYMTVAEAEELEEQKKKEEAIEIAALAGMVVLSCINPVAGAVAIGA
N315            KSDFEKMMTQGASCDYMTVAEAEEIEEQKKKEEAIEIAALAGMVVLSCINPVAGAVAIGA
NCTC8325        KSDFEKMMTQGASCDYMTVAEAEELEEQKKKEEAIEIAALAGMVVLSCINPVAGAVAIGA
Newman          KSDFEKMMTQGASCDYMTVAEAEELEEQKKKEEAIEIAALAGMVVLSCINPVAGAVAIGA
USA300_FPR3757  KSDFEKMMTQGASCDYMTVAEAEELEEQKKKEEAIEIAALAGMVVLSCINPVAGAVAIGA
JSNZ            KSDFEKMMTQGASCDYMTVAEAEEIEEQKKKEEAIEVAALAGMVVLSCINPVAGAVAIGA
                ************************:***********:***********************

COL             YSAYSAANAATGKNIVTGRKLSKEERIMEGLSLIPLPGMGFLKGAGKSLMKLGFKGGEKF
N315            YSAYSAANAATGKNIVTGRKLSKEERIMEGLSLIPLPGMGFLKGAGKSLMKLGFKGGEKF
NCTC8325        YSAYSAANAATGKNIVTGRKLSKEERIMEGLSLIPLPGMGFLKGAGKSLMKLGFKGGEKF
Newman          YSAYSAANAATGKNIVTGRKLSKEERIMEGLSLIPLPGMGFLKGAGKSLMKLGFKGGEKF
USA300_FPR3757  YSAYSAANAATGKNIVTGRKLSKEERIMEGLSLIPLPGMGFLKGAGKSLMKLGFKGGEKF
JSNZ            YSAYSAANAATGKNIVTGRKLSKEERIMEGLSLIPLPGMGFLKGAGKSLMKLGFKGGEKF
                ************************************************************

COL             AVKTGLQKTMQQAVSRISPKMGMMKNSVLNQSRNFAQNTHVGQMLSNMRGQATHTVQQSR
N315            AVKTGLQKTMQQAVSRISPKMGMMKNSVLNQSRNFAQNTHVGQMLSNMRGQATHTVQQSR
NCTC8325        AVKTGLQKTMQQAVSRISPKMGMMKNSVLNQSRNFAQNTHVGQMLSNMRGQATHTVQQSR
Newman          AVKTGLQKTMQQAVSRISPKMGMMKNSVLNQSRNFAQNTHVGQMLSNMRGQATHTVQQSR
USA300_FPR3757  AVKTGLQKTMQQAVSRISPKMGMMKNSVLNQSRNFAQNTHVGQMLSNMRGQATHTVQQSR
JSNZ            AVKTGLQKTMQQAVSRISPKMGMMKNSVLNQSRNFAQNTHVGQMLSNMRGQATHTVQQSR
                ************************************************************

COL             NWIGQQAQNVKRIVNNGLDKEIAHPFKQQLAPAGMGGIKFAETTTLRNMGQNIKRAVTPQ
N315            NWIGQQAQNVKRIVNNGLDKEIAHPFKQQLAPAGMGGIKFAETTTLRNMGQNMKRAVTPQ
NCTC8325        NWIGQQAQNVKRIVNNGLDKEIAHPFKQQLAPAGMGGIKFAETTTLRNMGQNIKRAVTPQ
Newman          NWIGQQAQNVKRIVNNGLDKEIAHPFKQQLAPAGMGGIKFAETTTLRNMGQNIKRAVTPQ
USA300_FPR3757  NWIGQQAQNVKRIVNNGLDKEIAHPFKQQLAPAGMGGIKFAETTTLRNMGQNIKRAVTPQ
JSNZ            NWIGQQAQNVKRIVNNGLDKEIAHPFKQQLAPAGMGGIKFAETTTLRNMGQNMKRAVTPQ
                ****************************************************:*******

COL             NHVTHGPKDSMVRSEGKHSISSHEMNSSKYVESPNYTKVEFGEHYARLRPKKLKANIEYT
N315            NHVTHGPKDSMVRSEGKHSVSSHEINLSKYVESPNYTKVKYGEQYARLRPKKLKANIEYT
NCTC8325        NHVTHGPKDSMVRSEGKHSISSHEMNSSKYVESPNYTKVEFGEHYARLRPKKLKANIEYT
Newman          NHVTHGPKDSMVRSEGKHSISSHEMNSSKYVESPNYTKVEFGEHYARLRPKKLKANIEYT
USA300_FPR3757  NHVTHGPKDSMVRSEGKHSISSHEMNSSKYVESPNYTKVEFGEHYARLRPKKLKANIEYT
JSNZ            NHVTHGPKDSMVRSEGKHSVSSHEINSSKYVESPNYTKVEFGEHYARLRPKKLKANIEYT
                *******************:****:* ************::**:****************

COL             TPTGHIYRTDHKGRIKEVYVDNLSLKDGDRNSHAQRTVGGEDRLPDDDGGHLIARMFGGS
N315            TPTGHIYRTDHKGRIKEVYVDNLSLKDGGRNNHAQRTVGGEDRLPDDDGGHLIARMFGGS
NCTC8325        TPTGHIYRTDHKGRIKEVYVDNLSLKDGDRNSHAQRTVGGEDRLPDDDGGHLIARMFGGS
Newman          TPTGHIYRTDHKGRIKEVYVDNLSLKDGDRNSHAQRTVGGEDRLPDDDGGHLIARMFGGS
USA300_FPR3757  TPTGHIYRTDHKGRIKEVYVDNLSLKDGDRNSHAQRTVGGEDRLPDDDGGHLIARMFGGS
JSNZ            TPNGHIYRTDHKGRIKEVYVDNLSLKDGDRNNYAQKTVGGEDRLPDDDGGHLIARMFGGS
                **.*************************.**.:**:************************

COL             KDIDNLVAQSKFINRPFKEKGHWYNLEKEWQEFLNSGKEVKNIKMEVKYSGNSQRPTIFK
N315            KDIDNLVAQSKYINRSFKENGDWYKLEKLWEKAIKSGKSIENIKIEVKYKGNSQRPTIFK
NCTC8325        KDIDNLVAQSKFINRPFKEKGHWYNLEKEWQEFLNSGKEVKNIKMEVKYSGNSQRPTIFK
Newman          KDIDNLVAQSKFINRPFKEKGHWYNLEKEWQEFLNSGKEVKNIKMEVKYSGNSQRPTIFK
USA300_FPR3757  KDIDNLVAQSKFINRPFKEKGHWYNLEKEWQEFLNSGKEVKNIKMEVKYSGNSQRPTIFK
JSNZ            KDIDNLVAQSKFINRPFKENGDWYNLEKEWQEFLNSGNEVKNIKMEVKYSGNSKRPIEFN
                ***********:***.***:*.**:*** *:: ::**:.::***:****.***:**  *:

COL             VEYEINGERNIRRILNK
N315            VEYEINGKRNIRRILNK
NCTC8325        VEYEINGERNIRRILNK
Newman          VEYEINGERNIRRILNK
USA300_FPR3757  VEYEINGERNIRRILNK
JSNZ            VSYEINNKPKVKTIENI
                *.****.: ::: * *

↑ Ryan Jay Ohr, Mark Anderson, Miaomiao Shi, Olaf Schneewind, Dominique Missiakas
EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.
J Bacteriol: 2017, 199(1);
[PubMed:27795323] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)

[1] Ryan Jay Ohr, Mark Anderson, Miaomiao Shi, Olaf Schneewind, Dominique Missiakas
EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway.
J Bacteriol: 2017, 199(1);
[PubMed:27795323] [WorldCat.org] [DOI] (I e)Stephen R Garrett, Giuseppina Mariano, Jo Dicks, Tracy Palmer
Homologous recombination between tandem paralogues drives evolution of a subset of type VII secretion system immunity genes in firmicute bacteria.
Microb Genom: 2022, 8(8);
[PubMed:35960642] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]