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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN001816000
  • symbol?:
  • synonym:
  • description?: minor structural protein

      descriptions from strain specific annotations:

    • minor structural protein
    • phiSLT ORF636-like protein
    • SLT orf 636-like protein
    • lytic system
    • phage protein
    • phi SLT phage protein
  • strand?: -
  • coordinates?: 2251050..2253301
  • synteny block?: BlockID0011920
  • occurrence?: in 26% of 34 strains

rbp : serogroup A prophage teichoic acid receptor binding protein [1]

Staphylococcal prophage recognize several elements of the staphylococcal cell envelope to guide primary attachment. Receptor binding proteins primarily recognize N-acetylglucosamine-decorated teichoic acids, although there is some inconsistency in the literature whether there is a distinction between lipoteichoic acid or wall teichoic acid binding. This variant appears to primarily recognize lipoteichoic acid with distinctions based on LTA D-alanylation, lysinylation and glycosylation. After primary attachment, receptor binding protein has a second recognition function for O-acetylated peptidoglycan. Individual rbp variants within serogroups may have enhanced recognition for different epitopes, α- or β-linked N-acetylglucosamine, resistance to secondary teichoic acid modifications, etc. which results in different host range trophisms. Further host range distinctions come from interactions between side fiber proteins, which may or may not be present, and host cell envelope epitopes.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    C248_0365
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    SAEMRSA15_13580
    JH1:
    JH9:
    JKD6008:
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    SAR1503
    MSHR1132:
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    SAPIG0390
    T0131:
    TCH60:
    HMPREF0772_11706
    TW20:
    USA300_TCH1516:
    USA300HOU_1437
    VC40:

Genome Viewer[edit | edit source]

COL
NCTC8325
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTMQHFAEQIYYNG
    NCTC8325        MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTIQHFAEQIYYNG
    USA300_FPR3757  MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTMQHFAEQIYYNG
                    ************************************************:***********

    COL             RSQAAVNKSLQSQINALVVAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKE
    NCTC8325        RSQAAVNKSLQSQINALVVAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKE
    USA300_FPR3757  RSQAAVNKSLQSQINALVVAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKE
                    ************************************************************

    COL             ETIRELNKTKQEILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARN
    NCTC8325        ETIRELNKTKQEILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARN
    USA300_FPR3757  ETIRELNKTKQEILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARN
                    ************************************************************

    COL             NGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTP
    NCTC8325        NGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTP
    USA300_FPR3757  NGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTP
                    ************************************************************

    COL             NVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSL
    NCTC8325        NVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSL
    USA300_FPR3757  NVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSL
                    ************************************************************

    COL             DDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETG
    NCTC8325        DDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETG
    USA300_FPR3757  DDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETG
                    ************************************************************

    COL             EEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIG
    NCTC8325        EEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIG
    USA300_FPR3757  EEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIG
                    ************************************************************

    COL             QRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFP
    NCTC8325        QRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFP
    USA300_FPR3757  QRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFP
                    ************************************************************

    COL             LPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNS
    NCTC8325        LPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNS
    USA300_FPR3757  LPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNS
                    ************************************************************

    COL             GKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVH
    NCTC8325        GKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVH
    USA300_FPR3757  GKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVH
                    ************************************************************

    COL             RLVRNSVTASAEILLKNYDSKISSGPWTLHEGRIIS
    NCTC8325        RLVRNSVTASAEILLKNYDSKTSSGPWTLHEGRIIS
    USA300_FPR3757  RLVRNSVTASAEILLKNYDSKTSSGPWTLHEGRIIS
                    ********************* **************

  1. Jun Kaneko, Sachiko Narita-Yamada, Yukari Wakabayashi, Yoshiyuki Kamio
    Identification of ORF636 in phage phiSLT carrying Panton-Valentine leukocidin genes, acting as an adhesion protein for a poly(glycerophosphate) chain of lipoteichoic acid on the cell surface of Staphylococcus aureus.
    J Bacteriol: 2009, 191(14);4674-80
    [PubMed:19429614] [WorldCat.org] [DOI] (I p)
    Xuehua Li, Cengiz Koç, Petra Kühner, York-Dieter Stierhof, Bernhard Krismer, Mark C Enright, José R Penadés, Christiane Wolz, Thilo Stehle, Christian Cambillau, Andreas Peschel, Guoqing Xia
    An essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus.
    Sci Rep: 2016, 6;26455
    [PubMed:27212064] [WorldCat.org] [DOI] (I e)
    Cengiz Koç, Guoqing Xia, Petra Kühner, Silvia Spinelli, Alain Roussel, Christian Cambillau, Thilo Stehle
    Structure of the host-recognition device of Staphylococcus aureus phage ϕ11.
    Sci Rep: 2016, 6;27581
    [PubMed:27282779] [WorldCat.org] [DOI] (I e)
    Matthew Dunne, Mario Hupfeld, Jochen Klumpp, Martin J Loessner
    Molecular Basis of Bacterial Host Interactions by Gram-Positive Targeting Bacteriophages.
    Viruses: 2018, 10(8);
    [PubMed:30060549] [WorldCat.org] [DOI] (I e)