Jump to navigation
Jump to search
PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN001816000
- symbol?: —
- synonym:
- description?: minor structural protein
- minor structural protein
- phiSLT ORF636-like protein
- SLT orf 636-like protein
- lytic system
- phage protein
- phi SLT phage protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 2251050..2253301
- synteny block?: BlockID0011920
- occurrence?: in 26% of 34 strains
rbp : serogroup A prophage teichoic acid receptor binding protein [1]
Staphylococcal prophage recognize several elements of the staphylococcal cell envelope to guide primary attachment. Receptor binding proteins primarily recognize N-acetylglucosamine-decorated teichoic acids, although there is some inconsistency in the literature whether there is a distinction between lipoteichoic acid or wall teichoic acid binding. This variant appears to primarily recognize lipoteichoic acid with distinctions based on LTA D-alanylation, lysinylation and glycosylation. After primary attachment, receptor binding protein has a second recognition function for O-acetylated peptidoglycan. Individual rbp variants within serogroups may have enhanced recognition for different epitopes, α- or β-linked N-acetylglucosamine, resistance to secondary teichoic acid modifications, etc. which results in different host range trophisms. Further host range distinctions come from interactions between side fiber proteins, which may or may not be present, and host cell envelope epitopes.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
C248_0365
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_13580
JH1:
—
JH9:
—
JKD6008:
—
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR1503
MSHR1132:
—
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
SAPIG0390
T0131:
—
TCH60:
HMPREF0772_11706
TW20:
—
USA300_TCH1516:
USA300HOU_1437
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTMQHFAEQIYYNG
NCTC8325 MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTIQHFAEQIYYNG
USA300_FPR3757 MENLYLIKDLGALAGRDYRAKEIQNLQRIEQFALGLTTEFKLHQKAKTMQHFAEQIYYNG
************************************************:***********
COL RSQAAVNKSLQSQINALVVAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKE
NCTC8325 RSQAAVNKSLQSQINALVVAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKE
USA300_FPR3757 RSQAAVNKSLQSQINALVVAPRNNSANEIVQARVNVNGETFDTLKEHLDDWETKTQINKE
************************************************************
COL ETIRELNKTKQEILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARN
NCTC8325 ETIRELNKTKQEILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARN
USA300_FPR3757 ETIRELNKTKQEILDIEYRFEPDKQEFLFVTELAPLTNAVMQSFWFDNRTGIVYMTQARN
************************************************************
COL NGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTP
NCTC8325 NGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTP
USA300_FPR3757 NGYMLSRLRPNGQFIDSSLIVGGGHGTHNGYRYIDDELWIYSFILNGNNENTLVRFKYTP
************************************************************
COL NVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSL
NCTC8325 NVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSL
USA300_FPR3757 NVEISYGKYGMQDVFTGHPEKPYITPVINEKENKILYRIERPRSQWELENSMNYIEIRSL
************************************************************
COL DDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETG
NCTC8325 DDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETG
USA300_FPR3757 DDVDKNIDKVLHKISIPMRLTNETQPMQGVTFDEKYLYWYTGDSNPNNRNYLTAFDLETG
************************************************************
COL EEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIG
NCTC8325 EEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIG
USA300_FPR3757 EEAYQVNADYGGTLDSFPGEFAEAEGLQIYYDKDSGKKALMLGVTVGGDGNRTHRIFMIG
************************************************************
COL QRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFP
NCTC8325 QRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFP
USA300_FPR3757 QRGILEILHSRGVPFIMSDTGGRVKPLPMRPDKLKNLGMLTEPGLYYLYTDHTVQIDDFP
************************************************************
COL LPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNS
NCTC8325 LPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNS
USA300_FPR3757 LPREWRDAGWFLEVKPPQTGGDVIQILTRNSYARNMMTFERVLSGRTGDISDWNYVPKNS
************************************************************
COL GKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVH
NCTC8325 GKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVH
USA300_FPR3757 GKWERVPSFITKMSDINIVGMSFYLTTDDTKRFTDFPTERKGVAGWNLYVEASNTGGFVH
************************************************************
COL RLVRNSVTASAEILLKNYDSKISSGPWTLHEGRIIS
NCTC8325 RLVRNSVTASAEILLKNYDSKTSSGPWTLHEGRIIS
USA300_FPR3757 RLVRNSVTASAEILLKNYDSKTSSGPWTLHEGRIIS
********************* **************
- ↑ Jun Kaneko, Sachiko Narita-Yamada, Yukari Wakabayashi, Yoshiyuki Kamio
Identification of ORF636 in phage phiSLT carrying Panton-Valentine leukocidin genes, acting as an adhesion protein for a poly(glycerophosphate) chain of lipoteichoic acid on the cell surface of Staphylococcus aureus.
J Bacteriol: 2009, 191(14);4674-80
[PubMed:19429614] [WorldCat.org] [DOI] (I p)Xuehua Li, Cengiz Koç, Petra Kühner, York-Dieter Stierhof, Bernhard Krismer, Mark C Enright, José R Penadés, Christiane Wolz, Thilo Stehle, Christian Cambillau, Andreas Peschel, Guoqing Xia
An essential role for the baseplate protein Gp45 in phage adsorption to Staphylococcus aureus.
Sci Rep: 2016, 6;26455
[PubMed:27212064] [WorldCat.org] [DOI] (I e)Cengiz Koç, Guoqing Xia, Petra Kühner, Silvia Spinelli, Alain Roussel, Christian Cambillau, Thilo Stehle
Structure of the host-recognition device of Staphylococcus aureus phage ϕ11.
Sci Rep: 2016, 6;27581
[PubMed:27282779] [WorldCat.org] [DOI] (I e)Matthew Dunne, Mario Hupfeld, Jochen Klumpp, Martin J Loessner
Molecular Basis of Bacterial Host Interactions by Gram-Positive Targeting Bacteriophages.
Viruses: 2018, 10(8);
[PubMed:30060549] [WorldCat.org] [DOI] (I e)