⊟Summary[edit | edit source]
- pan ID?: SAUPAN001826000
- symbol?: —
- synonym:
- description?: tail protein
- tail protein
- major tail protein
- phiSLT ORF213-like protein, major tail protein
- prophage L54a, major tail protein
- phage major tail , phi13 family protein
- phi13 family phage major tail protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 2272299..2272947
- synteny block?: BlockID0012020
- occurrence?: in 45% of 33 strains
mtpL : serogroup A prophage major tail tube protein large subunit [1]
Most staphylococcal prophages require two major tail tube proteins to form orderly coiled polymers around the tail tape measure protein. While some prophage encode the two tail tube proteins as a single gene with a programmed translational frameshift, Serogroup A prophage encode them as two separate genes. After nucleation at the distal baseplate, MtpS monomers polymerize, spiraling their way up the tail tape measure protein, displacing tail assembly chaperones and incorporating MtpL monomers as necessary to maintain proper tight spirals. Upon reaching the end of the tape measure protein, the final MtpS spiral is stabilized by a ring of tail-completion/"neck" proteins resulting in a tail tube that is structurally-secure and competent for binding to phage capsids.
⊟Orthologs[edit | edit source]
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAEGQGSYKVGFKRLYVGVFNPEATKVVKRMTWEDEKGGTVDLNITGLAPDLVDMFASNK
NCTC8325 MAEGQGSYKVGFKRLYVGVFNPEATKVVKRMTWEDEKGGTVDLNITGLAPDLVDMFASNK
USA300_FPR3757 MAEGQGSYKVGFKRLYVGVFNPEATKVVKRMTWEDEKGGTVDLNITGLAPDLVDMFASNK
************************************************************
COL RVWMKKQGTNEVKSDMSIFNIPSDDLNTVIGRTKDKNGTSWVGENTRAPYVTVIGESEDG
NCTC8325 RVWMKKQGTNEVKSDMSIFNIPSDDLNTVIGRTKDKNGTSWVGENTRAPYVTVIGESEDG
USA300_FPR3757 RVWMKKQGTNEVKSDMSIFNIPSDDLNTVIGRTKDKNGTSWVGENTRAPYVTVIGESEDG
************************************************************
COL LTGQPVYVALLKGTFSLDSIEFKTRGEKAEAPEPTKLTGDWMNRKVDVDGTSQGIVYGYH
NCTC8325 LTGQPVYVALLKGTFSLDSIEFKTRGEKAEAPEPTKLTGDWMNRKVDVDGTSQGIVYGYH
USA300_FPR3757 LTGQPVYVALLKGTFSLDSIEFKTRGEKAEAPEPTKLTGDWMNRKVDVDGTSQGIVYGYH
************************************************************
COL EGKEGEAEFFKKVFVGYTDSEDHSEDSAGSLPS
NCTC8325 EGKEGEAEFFKKVFVGYTDSEDHSEDSAGSLPS
USA300_FPR3757 EGKEGEAEFFKKVFVGYTDSEDHSEDSAGSLPS
*********************************
- ↑ Jun Xu, Roger W Hendrix, Robert L Duda
Conserved translational frameshift in dsDNA bacteriophage tail assembly genes.
Mol Cell: 2004, 16(1);11-21
[PubMed:15469818] [WorldCat.org] [DOI] (P p)Isabelle Auzat, Anja Dröge, Frank Weise, Rudi Lurz, Paulo Tavares
Origin and function of the two major tail proteins of bacteriophage SPP1.
Mol Microbiol: 2008, 70(3);557-69
[PubMed:18786146] [WorldCat.org] [DOI] (I p)