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⊟Summary[edit | edit source]
- pan ID?: SAUPAN001869000
- symbol?: mepA
- synonym:
- description?: multidrug efflux MATE transporter MepA
- multidrug efflux MATE transporter MepA
- MATE efflux family protein
- mepA: Multidrug export protein mepA
- Multidrug export protein mepA
- MATE family multi-antimicrobial extrusion protein
- MDR efflux family protein
- Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 2364066..2365421
- synteny block?: BlockID0012430
- occurrence?: in 100% of 33 strains
mepA1 : multidrug efflux MATE transporter 1 [1]
There is some confusion in the S. aureus literature regarding the MepRA transporters. Multiple papers and two crystal structures are available referring to two separate operons as MepRA. For clarity, we will annotate the operon between the ascorbate phosphotransferase operon and the glycerol-3-phosphate transporter (3ECO) as "Mep1" and the one between femX and sarV (4EM1) as Mep2.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0333
08BA02176:
C248_0389
11819-97:
MS7_0324 (mepA)
6850:
RSAU_000280 (mepA)
71193:
ST398NM01_0415
ECT-R 2:
ECTR2_294
ED133:
SAOV_0359
ED98:
SAAV_0302
HO 5096 0412:
SAEMRSA15_02900
JH1:
SaurJH1_0393
JH9:
SaurJH9_0383
JKD6008:
SAA6008_00311 (mepA)
JKD6159:
SAA6159_00309 (mepA)
LGA251:
SARLGA251_02950 (mepA)
M013:
M013TW_0314
MRSA252:
SAR0331
MSHR1132:
SAMSHR1132_03080
MSSA476:
SAS0311
Mu3:
SAHV_0331
Mu50:
SAV0334
MW2:
MW0311
RF122:
SAB0284
ST398:
SAPIG0415
T0131:
SAT0131_00339
TCH60:
HMPREF0772_10161 (mepA)
TW20:
SATW20_04020 (mepA)
USA300_TCH1516:
USA300HOU_0355
VC40:
SAVC_01420
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLP
N315 MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLP
NCTC8325 MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLP
Newman MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLP
USA300_FPR3757 MKDEQLYYFEKSPVFKAMMHFSLPMMIGTLLSVIYGILNIYFIGFLEDSHMISAISLTLP
************************************************************
COL VFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVTLPFSDQ
N315 VFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVTLPFSDQ
NCTC8325 VFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVTLPFSDQ
Newman VFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVTLPFSDQ
USA300_FPR3757 VFAILMGLGNLFGVGAGTYISRLLGAKDYSKSKFVSSFSIYGGIALGLIVILVTLPFSDQ
************************************************************
COL IAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMVSMIGMLASVGLNI
N315 IAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMISMIGMLASVGLNI
NCTC8325 IAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMVSMIGMLASVGLNI
Newman IAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMVSMIGMLASVGLNI
USA300_FPR3757 IAAILGARGETLALTSNYLKVMFLSAPFVILFFILEQFARAIGAPMVSMIGMLASVGLNI
**********************************************:*************
COL ILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEI
N315 ILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEI
NCTC8325 ILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEI
Newman ILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEI
USA300_FPR3757 ILDPILIFGFDLNVVGAALGTAISNVAAALFFIIYFMKNSDVVSVNIKLAKPNKEMLSEI
************************************************************
COL FKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPL
N315 FKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPL
NCTC8325 FKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPL
Newman FKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPL
USA300_FPR3757 FKIGIPAFLMSILMGFTGLVLNLFLAHYGNFAIASYGISFRLVQFPELIIMGLCEGVVPL
************************************************************
COL IAYNFMANKGRMKDVIKAVIMSIGVIFVVCMSAVFTIGHHMVGLFTTDQAIVEMATFILK
N315 IAYNFMANKGRMKDVIKAVIMSIGVIFVVCMIAVFTIGHHMVGLFTTDQAIVEMATFILK
NCTC8325 IAYNFMANKGRMKDVIKAVIMSIGVIFVVCMSAVFTIGHHMVGLFTTDQAIVEMATFILK
Newman IAYNFMANKGRMKDVIKAVIMSIGVIFVVCMSAVFTIGHHMVGLFTTDQAIVEMATFILK
USA300_FPR3757 IAYNFMANKGRMKDVIKAVIMSIGVIFVVCMSAVFTIGHHMVGLFTTDQAIVEMATFILK
******************************* ****************************
COL VTMASLLLNGIGFLFTGMLQATGQGRGATIMAILQGAIIIPVLFIMNALFGLTGVIWSLL
N315 VTMASLLLNGIGFLFTGMLQATGQGRGATIMAILQGAIIIPVLFIMNALFGLTGVIWSLL
NCTC8325 VTMASLLLNGIGFLFTGMLQATGQGRGATIMAILQGAIIIPVLFIMNALFGLTGVIWSLL
Newman VTMASLLLNGIGFLFTGMLQATGQGRGATIMAILQGAIIIPVLFIMNALFGLTGVIWSLL
USA300_FPR3757 VTMASLLLNGIGFLFTGMLQATGQGRGATIMAILQGAIIIPVLFIMNALFGLTGVIWSLL
************************************************************
COL IAESLCALAAMLIVYLLRDRLTVDTSELIEG
N315 IAESLCALAAMLIVYLLRDRLTVDTSELIEG
NCTC8325 IAESLCALAAMLIVYLLRDRLTVDTSELIEG
Newman IAESLCALAAMLIVYLLRDRLTVDTSELIEG
USA300_FPR3757 IAESLCALAAMLIVYLLRDRLTVDTSELIEG
*******************************
- ↑ Ivan Birukou, Susan M Seo, Bryan D Schindler, Glenn W Kaatz, Richard G Brennan
Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR.
Nucleic Acids Res: 2014, 42(4);2774-88
[PubMed:24293644] [WorldCat.org] [DOI] (I p)