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Summary[edit | edit source]

  • pan ID?: SAUPAN002338000
  • symbol?:
  • synonym:
  • description?: glycosyl transferase family 1

      descriptions from strain specific annotations:

    • glycosyl transferase family 1
    • glycosyltransferase
    • glycosyl transferase, group 1 family protein
    • glycosyl transferase, putative
    • poly (glycerol-phosphate) alpha-glucosyltransferase
    • putative glycosyl transferase
    • glycoside hydrolase family protein
    • glycosyl transferase family protein
    • glycosyl transferases group 1 family protein
    • group 1 glycosyl transferase
    • putative poly(Glycerol-phosphate)alpha-glucosyltransferase
  • strand?: +
  • coordinates?: 2876798..2878270
  • synteny block?: BlockID0016370
  • occurrence?: in 100% of 34 strains

sdgA : serine-aspartate repeat protein O-glycosyltransferase SdgA [1]

• A crystal structure is available: 7EC1

SdgB can add a single N-acetylglucosamine residue to each aspartate of an SD-repeat. SdgA can extend NAG-primed asparates by an additional N-acetylglucosamine resulting in NAG-NAG disaccharide-modified serine-aspartate repeat proteins.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_0541
    08BA02176:
    C248_0639
    11819-97:
    MS7_0554
    6850:
    RSAU_000518
    71193:
    ST398NM01_0638
    ECT-R 2:
    ECTR2_518
    ED133:
    SAOV_0599
    ED98:
    SAAV_0527
    HO 5096 0412:
    SAEMRSA15_04910
    JH1:
    SaurJH1_0601
    JH9:
    SaurJH9_0587
    JKD6008:
    SAA6008_00572
    JKD6159:
    SAA6159_00518
    JSNZ:
    JSNZ_000522
    LGA251:
    SARLGA251_05000
    M013:
    M013TW_0551
    MRSA252:
    SAR0568
    MSHR1132:
    SAMSHR1132_05080
    MSSA476:
    SAS0522
    Mu3:
    SAHV_0562
    Mu50:
    SAV0564
    MW2:
    MW0519
    RF122:
    SAB0514
    ST398:
    SAPIG0638
    T0131:
    SAT0131_00625
    TCH60:
    HMPREF0772_12625
    TW20:
    SATW20_06340
    USA300_TCH1516:
    USA300HOU_0558
    VC40:
    SAVC_02410

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
    N315            MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
    NCTC8325        MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
    Newman          MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
    USA300_FPR3757  MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
                    ************************************************************

    COL             MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
    N315            MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
    NCTC8325        MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
    Newman          MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
    USA300_FPR3757  MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
                    ************************************************************

    COL             QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
    N315            QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
    NCTC8325        QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
    Newman          QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
    USA300_FPR3757  QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
                    ************************************************************

    COL             GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
    N315            GKNTLTKVILNEDQQQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
    NCTC8325        GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
    Newman          GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
    USA300_FPR3757  GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
                    **************:*********************************************

    COL             VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
    N315            VVVVLHSTHLSGTGNGIKSFYKTVFNNLTRYKAIVVSTEQQCQDISQYIENKIPVINIPV
    NCTC8325        VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
    Newman          VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
    USA300_FPR3757  VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
                    *:**********:**************************:********************

    COL             GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
    N315            GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
    NCTC8325        GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
    Newman          GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
    USA300_FPR3757  GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
                    ************************************************************

    COL             SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
    N315            SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
    NCTC8325        SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
    Newman          SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
    USA300_FPR3757  SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
                    ************************************************************

    COL             YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
    N315            YDIDYGPSELIQDGFNGYLVPKGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
    NCTC8325        YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
    Newman          YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
    USA300_FPR3757  YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
                    **:******************:**************************************

    COL             ISTKWQNILN
    N315            ISTKWQNILN
    NCTC8325        ISTKWQNILN
    Newman          ISTKWQNILN
    USA300_FPR3757  ISTKWQNILN
                    **********

  1. Dong Gyun Kim, Inwha Baek, Yeon Lee, Hyerry Kim, Jin Young Kim, Geul Bang, Sunghwan Kim, Hye Jin Yoon, Byung Woo Han, Se Won Suh, Hyoun Sook Kim
    Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
    Acta Crystallogr D Struct Biol: 2021, 77(Pt 11);1460-1474
    [PubMed:34726173] [WorldCat.org] [DOI] (I p)
    Wouter L W Hazenbos, Kimberly K Kajihara, Richard Vandlen, J Hiroshi Morisaki, Sophie M Lehar, Mark J Kwakkenbos, Tim Beaumont, Arjen Q Bakker, Qui Phung, Lee R Swem, Satish Ramakrishnan, Janice Kim, Min Xu, Ishita M Shah, Binh An Diep, Tao Sai, Andrew Sebrell, Yana Khalfin, Angela Oh, Chris Koth, S Jack Lin, Byoung-Chul Lee, Magnus Strandh, Klaus Koefoed, Peter S Andersen, Hergen Spits, Eric J Brown, Man-Wah Tan, Sanjeev Mariathasan
    Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.
    PLoS Pathog: 2013, 9(10);e1003653
    [PubMed:24130480] [WorldCat.org] [DOI] (I p)