⊟Summary[edit | edit source]

pan ID^?: SAUPAN002338000
symbol^?: —
synonym:
description^?: glycosyl transferase family 1
- glycosyl transferase family 1
- glycosyltransferase
- glycosyl transferase, group 1 family protein
- glycosyl transferase, putative
- poly (glycerol-phosphate) alpha-glucosyltransferase
- putative glycosyl transferase
- glycoside hydrolase family protein
- glycosyl transferase family protein
- glycosyl transferases group 1 family protein
- group 1 glycosyl transferase
- putative poly(Glycerol-phosphate)alpha-glucosyltransferase
strand^?: +
coordinates^?: 2876798..2878270
synteny block^?: BlockID0016370
occurrence^?: in 100% of 34 strains

sdgA : serine-aspartate repeat protein O-glycosyltransferase SdgA ^[1]

• A crystal structure is available: 7EC1

• SdgB can add a single N-acetylglucosamine residue to each aspartate of an SD-repeat. SdgA can extend NAG-primed asparates by an additional N-acetylglucosamine resulting in NAG-NAG disaccharide-modified serine-aspartate repeat proteins.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

04-02981:

SA2981_0541

08BA02176:

C248_0639

11819-97:

MS7_0554

6850:

RSAU_000518

71193:

ST398NM01_0638

ECT-R 2:

ECTR2_518

ED133:

SAOV_0599

ED98:

SAAV_0527

HO 5096 0412:

SAEMRSA15_04910

JH1:

SaurJH1_0601

JH9:

SaurJH9_0587

JKD6008:

SAA6008_00572

JKD6159:

SAA6159_00518

JSNZ:

JSNZ_000522

LGA251:

SARLGA251_05000

M013:

M013TW_0551

MRSA252:

SAR0568

MSHR1132:

SAMSHR1132_05080

MSSA476:

SAS0522

Mu3:

SAHV_0562

Mu50:

SAV0564

MW2:

MW0519

RF122:

SAB0514

ST398:

SAPIG0638

T0131:

SAT0131_00625

TCH60:

HMPREF0772_12625

TW20:

SATW20_06340

USA300_TCH1516:

USA300HOU_0558

VC40:

SAVC_02410

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
N315            MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
NCTC8325        MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
Newman          MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
USA300_FPR3757  MNYILGTILESKITGVEKAQINRLKLFKQHGISSKCVYVKWNPYSYTYAKQHQIENDVFT
                ************************************************************

COL             MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
N315            MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
NCTC8325        MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
Newman          MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
USA300_FPR3757  MYDYFQKAINYKKTKQVNWIQYWEKSCRYTLKFVENSNDVRIYDEEQFVMYAHFLDKQYH
                ************************************************************

COL             QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
N315            QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
NCTC8325        QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
Newman          QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
USA300_FPR3757  QLNYVNYFDHKRRKVKRELYDGRGFLSCSRILGEGQRIVLENYYTPNGEIVIQKYFDDIK
                ************************************************************

COL             GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
N315            GKNTLTKVILNEDQQQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
NCTC8325        GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
Newman          GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
USA300_FPR3757  GKNTLTKVILNEDQHQQFFDTEDELVQYFLHQLCKNNDQIILDRPHELGNVIAGLNQSIP
                **************:*********************************************

COL             VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
N315            VVVVLHSTHLSGTGNGIKSFYKTVFNNLTRYKAIVVSTEQQCQDISQYIENKIPVINIPV
NCTC8325        VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
Newman          VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
USA300_FPR3757  VIVVLHSTHLSGAGNGIKSFYKTVFNNLTRYKAIVVSTEKQCQDISQYIENKIPVINIPV
                *:**********:**************************:********************

COL             GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
N315            GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
NCTC8325        GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
Newman          GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
USA300_FPR3757  GYVANLKYQFDINQKEKNHIISIARLVENKQIKHQIEVIKQLVTKHPNIQLNIYGHGNGL
                ************************************************************

COL             SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
N315            SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
NCTC8325        SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
Newman          SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
USA300_FPR3757  SEYRQLVEDYHLSEHVKFHGFKTHINEEIAKAELMLSTSKMEGFGLAILESLSVGTPVIS
                ************************************************************

COL             YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
N315            YDIDYGPSELIQDGFNGYLVPKGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
NCTC8325        YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
Newman          YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
USA300_FPR3757  YDVDYGPSELIQDGFNGYLVPQGDINQMVEKVDQLLNNTQKLQQFSINSIESAQQYNATT
                **:******************:**************************************

COL             ISTKWQNILN
N315            ISTKWQNILN
NCTC8325        ISTKWQNILN
Newman          ISTKWQNILN
USA300_FPR3757  ISTKWQNILN
                **********

↑ Dong Gyun Kim, Inwha Baek, Yeon Lee, Hyerry Kim, Jin Young Kim, Geul Bang, Sunghwan Kim, Hye Jin Yoon, Byung Woo Han, Se Won Suh, Hyoun Sook Kim
Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol: 2021, 77(Pt 11);1460-1474
[PubMed:34726173] [WorldCat.org] [DOI] (I p)Wouter L W Hazenbos, Kimberly K Kajihara, Richard Vandlen, J Hiroshi Morisaki, Sophie M Lehar, Mark J Kwakkenbos, Tim Beaumont, Arjen Q Bakker, Qui Phung, Lee R Swem, Satish Ramakrishnan, Janice Kim, Min Xu, Ishita M Shah, Binh An Diep, Tao Sai, Andrew Sebrell, Yana Khalfin, Angela Oh, Chris Koth, S Jack Lin, Byoung-Chul Lee, Magnus Strandh, Klaus Koefoed, Peter S Andersen, Hergen Spits, Eric J Brown, Man-Wah Tan, Sanjeev Mariathasan
Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.
PLoS Pathog: 2013, 9(10);e1003653
[PubMed:24130480] [WorldCat.org] [DOI] (I p)

[1] Dong Gyun Kim, Inwha Baek, Yeon Lee, Hyerry Kim, Jin Young Kim, Geul Bang, Sunghwan Kim, Hye Jin Yoon, Byung Woo Han, Se Won Suh, Hyoun Sook Kim
Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol: 2021, 77(Pt 11);1460-1474
[PubMed:34726173] [WorldCat.org] [DOI] (I p)Wouter L W Hazenbos, Kimberly K Kajihara, Richard Vandlen, J Hiroshi Morisaki, Sophie M Lehar, Mark J Kwakkenbos, Tim Beaumont, Arjen Q Bakker, Qui Phung, Lee R Swem, Satish Ramakrishnan, Janice Kim, Min Xu, Ishita M Shah, Binh An Diep, Tao Sai, Andrew Sebrell, Yana Khalfin, Angela Oh, Chris Koth, S Jack Lin, Byoung-Chul Lee, Magnus Strandh, Klaus Koefoed, Peter S Andersen, Hergen Spits, Eric J Brown, Man-Wah Tan, Sanjeev Mariathasan
Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.
PLoS Pathog: 2013, 9(10);e1003653
[PubMed:24130480] [WorldCat.org] [DOI] (I p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]