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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002515000
- symbol?: tagB
- synonym:
- description?: teichoic acid biosynthesis protein B
- teichoic acid biosynthesis protein B
- CDP-glycerol glycerophosphotransferase family protein
- teichoic acid biosynthesis protein B, putative
- teichoic acid biosynthesis protein TagB
- teichoic acid glycerol-phosphate primase TarB
- CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase
- CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase family protein
- Poly(glycerophosphate) glycerophosphotransferase family protein
- tagB protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3027911..3029014
- synteny block?: BlockID0017510
- occurrence?: in 88% of 34 strains
tarB (tagB): UDP-N-acetylglucosaminyl-N-acetylmannosamine glycerophosphotransferase [1]
TarB (alt: glycerol phosphate primase) catalyzes the third step of teichoic acid synthesis, adding a single equivalent of glycerol phosphate to the UDP-linked NAG-NAM disaccharide. Wall teichoic acids in S. aureus use ribitol exclusively as their polyol extension monomer, therefore WTA enzymes in S. aureus are assigned the "tar" nomenclature. In contrast, S. epidermidis uses glycerol as its polyol extension monomer so orthologous enzymes in S. epidermidis are assigned the "tag" nomenclature. The utilization of glycerol phosphate by TarB for polyol priming further blurs the line between the "Tar" and the "Tag" nomenclature but because the polymerizing polyol will be ribitol, it retains the "Tar" nomenclature.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
C248_0721 (tagB)
11819-97:
MS7_0690
6850:
RSAU_000595 (tagB)
71193:
ST398NM01_0718
ECT-R 2:
ECTR2_591
ED133:
SAOV_0674
ED98:
SAAV_0602 (tagB)
HO 5096 0412:
SAEMRSA15_05650 (tagB)
JH1:
SaurJH1_0677
JH9:
SaurJH9_0662
JKD6008:
SAA6008_00656 (tagB)
JKD6159:
SAA6159_00594 (tagB)
JSNZ:
JSNZ_000606 (tarB)
LGA251:
SARLGA251_05730 (tagB)
M013:
M013TW_0627
MRSA252:
SAR0649 (tagB)
MSHR1132:
SAMSHR1132_05850
MSSA476:
SAS0605
Mu3:
—
Mu50:
—
MW2:
MW0601 (tagB)
RF122:
SAB0589 (tagB)
ST398:
SAPIG0718
T0131:
SAT0131_00708 (camS)
TCH60:
HMPREF0772_12548 (tagB)
TW20:
SATW20_07140 (tagB)
USA300_TCH1516:
USA300HOU_0659 (tagB3)
VC40:
SAVC_02830
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
NCTC8325 MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
Newman MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
USA300_FPR3757 MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
************************************************************
COL KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
NCTC8325 KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
Newman KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
USA300_FPR3757 KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
************************************************************
COL HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
NCTC8325 HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
Newman HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
USA300_FPR3757 HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
************************************************************
COL YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
NCTC8325 YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
Newman YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
USA300_FPR3757 YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
************************************************************
COL YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
NCTC8325 YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
Newman YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
USA300_FPR3757 YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
************************************************************
COL TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
NCTC8325 TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
Newman TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
USA300_FPR3757 TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
************************************************************
COL IDKMVTK
NCTC8325 IDKMVTK
Newman IDKMVTK
USA300_FPR3757 IDKMVTK
*******
- ↑ Ziliang Qian, Yanbin Yin, Yong Zhang, Lingyi Lu, Yixue Li, Ying Jiang
Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication.
BMC Genomics: 2006, 7;74
[PubMed:16595020] [WorldCat.org] [DOI] (I e)