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Summary[edit | edit source]

  • pan ID?: SAUPAN002515000
  • symbol?: tagB
  • synonym:
  • description?: teichoic acid biosynthesis protein B

      descriptions from strain specific annotations:

    • teichoic acid biosynthesis protein B
    • CDP-glycerol glycerophosphotransferase family protein
    • teichoic acid biosynthesis protein B, putative
    • teichoic acid biosynthesis protein TagB
    • teichoic acid glycerol-phosphate primase TarB
    • CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase
    • CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase family protein
    • Poly(glycerophosphate) glycerophosphotransferase family protein
    • tagB protein
  • strand?: +
  • coordinates?: 3027911..3029014
  • synteny block?: BlockID0017510
  • occurrence?: in 88% of 34 strains

tarB (tagB): UDP-N-acetylglucosaminyl-N-acetylmannosamine glycerophosphotransferase [1]

TarB (alt: glycerol phosphate primase) catalyzes the third step of teichoic acid synthesis, adding a single equivalent of glycerol phosphate to the UDP-linked NAG-NAM disaccharide. Wall teichoic acids in S. aureus use ribitol exclusively as their polyol extension monomer, therefore WTA enzymes in S. aureus are assigned the "tar" nomenclature. In contrast, S. epidermidis uses glycerol as its polyol extension monomer so orthologous enzymes in S. epidermidis are assigned the "tag" nomenclature. The utilization of glycerol phosphate by TarB for polyol priming further blurs the line between the "Tar" and the "Tag" nomenclature but because the polymerizing polyol will be ribitol, it retains the "Tar" nomenclature.

Orthologs[edit | edit source]

    COL:
    SACOL0696 (tagB)
    N315:
    NCTC8325:
    Newman:
    NWMN_0609 (tagB)
    USA300_FPR3757:
    04-02981:
    08BA02176:
    C248_0721 (tagB)
    11819-97:
    MS7_0690
    6850:
    RSAU_000595 (tagB)
    71193:
    ST398NM01_0718
    ECT-R 2:
    ECTR2_591
    ED133:
    SAOV_0674
    ED98:
    SAAV_0602 (tagB)
    HO 5096 0412:
    SAEMRSA15_05650 (tagB)
    JH1:
    SaurJH1_0677
    JH9:
    SaurJH9_0662
    JKD6008:
    SAA6008_00656 (tagB)
    JKD6159:
    SAA6159_00594 (tagB)
    JSNZ:
    JSNZ_000606 (tarB)
    LGA251:
    SARLGA251_05730 (tagB)
    M013:
    M013TW_0627
    MRSA252:
    SAR0649 (tagB)
    MSHR1132:
    SAMSHR1132_05850
    MSSA476:
    SAS0605
    Mu3:
    Mu50:
    MW2:
    MW0601 (tagB)
    RF122:
    SAB0589 (tagB)
    ST398:
    SAPIG0718
    T0131:
    SAT0131_00708 (camS)
    TCH60:
    HMPREF0772_12548 (tagB)
    TW20:
    SATW20_07140 (tagB)
    USA300_TCH1516:
    USA300HOU_0659 (tagB3)
    VC40:
    SAVC_02830

Genome Viewer[edit | edit source]

COL
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
    NCTC8325        MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
    Newman          MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
    USA300_FPR3757  MNVLIKKFYHLVVRILSKMITPQVIDKPHIVFMMTFPEDIKPIIKALNNSSYQKTVLTTP
                    ************************************************************

    COL             KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
    NCTC8325        KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
    Newman          KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
    USA300_FPR3757  KQAPYLSELSDDVDVIEMTNRTLVKQIKALKSAQMIIIDNYYLLLGGYNKTSNQHIVQTW
                    ************************************************************

    COL             HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
    NCTC8325        HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
    Newman          HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
    USA300_FPR3757  HASGALKNFGLTDHQVDVSDKAMVQQYRKVYQATDFYLVGCEQMSQCFKQSLGATEEQML
                    ************************************************************

    COL             YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
    NCTC8325        YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
    Newman          YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
    USA300_FPR3757  YFGLPRINKYYTADRATVKAELKDKYGITNKLVLYVPTYREDKADNRAIDKAYFEKCLPG
                    ************************************************************

    COL             YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
    NCTC8325        YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
    Newman          YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
    USA300_FPR3757  YTLINKLHPSIEDSDIDDVSSIDTSTLMLMSDIIISDYSSLPIEASLLDIPTIFYVYDEG
                    ************************************************************

    COL             TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
    NCTC8325        TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
    Newman          TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
    USA300_FPR3757  TYDQVRGLNQFYKAIPDSYKVYTEEDLIMTIQEKEHLLSPLFKDWHKYNTDKSLHQLTEY
                    ************************************************************

    COL             IDKMVTK
    NCTC8325        IDKMVTK
    Newman          IDKMVTK
    USA300_FPR3757  IDKMVTK
                    *******

  1. Ziliang Qian, Yanbin Yin, Yong Zhang, Lingyi Lu, Yixue Li, Ying Jiang
    Genomic characterization of ribitol teichoic acid synthesis in Staphylococcus aureus: genes, genomic organization and gene duplication.
    BMC Genomics: 2006, 7;74
    [PubMed:16595020] [WorldCat.org] [DOI] (I e)