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⊟Summary[edit | edit source]
- pan ID?: SAUPAN002589000
- symbol?: csbB
- synonym:
- description?: glycosyltransferase
- glycosyltransferase
- glycosyl transferase, group 2 family protein
- bactoprenol glucosyl transferase, putative
- glycosyltransferase family 2 protein
- bactoprenol glucosyl transferase
- bactoprenol glucosyl transferase or stress response regulator
- CsbB stress response protein
- glucosyl transferase
- glycosyl transferase 2 family protein
- glycosyl transferase family protein
- group 2 glycosyl transferase
- putative glucosyl transferase
- putative glycosyltransferase csbB
- undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase
- Undecaprenyl-phosphate beta-N-acetylglucosaminyltransferase
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3102036..3103043
- synteny block?: BlockID0018250
- occurrence?: in 100% of 33 strains
csbB: cytoplasmic undecaprenol-N-acetylglucosamine glycosyltransferase [1]
CsbB is a part of the glycosylation pathway of extracellular lipoteichoic acid modifications
• In the LTA glycosylation pathway, CsbB transfers NAG to an undecaprenol carrier in the cytoplasm which traffics it to the inner leaflet of the cell membrane. GtcA flips it to the outer leaflet where YfhO can transfer NAG to the 2-OH of the extracellular poly-glycerophosphate LTA.
• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0681 (csbB)
08BA02176:
C248_0788
11819-97:
MS7_0755
6850:
RSAU_000679
71193:
ST398NM01_0781
ECT-R 2:
ECTR2_655
ED133:
SAOV_0738
ED98:
SAAV_0666
HO 5096 0412:
SAEMRSA15_06300
JH1:
SaurJH1_0744
JH9:
SaurJH9_0728
JKD6008:
SAA6008_00720
JKD6159:
SAA6159_00659
LGA251:
SARLGA251_06370
M013:
M013TW_0690
MRSA252:
SAR0757
MSHR1132:
SAMSHR1132_06490
MSSA476:
SAS0669
Mu3:
SAHV_0701
Mu50:
SAV0704
MW2:
MW0666
RF122:
SAB0653
ST398:
SAPIG0781
T0131:
SAT0131_00774
TCH60:
HMPREF0772_12483
TW20:
SATW20_07790
USA300_TCH1516:
USA300HOU_0727
VC40:
SAVC_03155
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKIRVVIPCFNEGEVITQTHQQLTEILSQDSSVKGYDYNMLFIDDGSTDTTIDEMQHLAT
N315 MKIRVVIPCFNEGEVITQTHQQLTEILSQDSSVKGYDYNMLFIDDGSTDTTIDEMQHLAT
NCTC8325 MKIRVVIPCFNEGEVITQTHQQLTEILSQDSSVKGYDYNMLFIDDGSTDTTIDEMQHLAT
Newman MKIRVVIPCFNEGEVITQTHQQLTEILSQDSSVKGYDYNMLFIDDGSTDTTIDEMQHLAT
USA300_FPR3757 MKIRVVIPCFNEGEVITQTHQQLTEILSQDSSVKGYDYNMLFIDDGSTDTTIDEMQHLAT
************************************************************
COL IDRHVSFISFSRNFGKEAAMIAGYQHSTEFDAVIMIDCDLQHPPEYIPKMVEGFMEGYDQ
N315 IDRHVSFISFSRNFGKEAAMIAGYQHSTEFDAVIMIDCDLQHPPEYIPKMVEGFMEGYDQ
NCTC8325 IDRHVSFISFSRNFGKEAAMIAGYQHSTEFDAVIMIDCDLQHPPEYIPKMVEGFMEGYDQ
Newman IDRHVSFISFSRNFGKEAAMIAGYQHSTEFDAVIMIDCDLQHPPEYIPKMVEGFMEGYDQ
USA300_FPR3757 IDRHVSFISFSRNFGKEAAMIAGYQHSTEFDAVIMIDCDLQHPPEYIPKMVEGFMEGYDQ
************************************************************
COL VIAKRDRSGENFSRKTLSHLYYKLVNCFVEEVQFDDGVGDFRLLSQRAVKSIASLEEYNR
N315 VIAKRDRSGENFSRKTLSHLYYKLVNCFVEEVQFDDGVGDFRLLSQRAVKSIASLEEYNR
NCTC8325 VIAKRDRSGENFSRKTLSHLYYKLVNCFVEEVQFDDGVGDFRLLSQRAVKSIASLEEYNR
Newman VIAKRDRSGENFSRKTLSHLYYKLVNCFVEEVQFDDGVGDFRLLSQRAVKSIASLEEYNR
USA300_FPR3757 VIAKRDRSGENFSRKTLSHLYYKLVNCFVEEVQFDDGVGDFRLLSQRAVKSIASLEEYNR
************************************************************
COL FSKGLFEWIGYNTKVFTYQNVERQKGESKWSFKKLFNYGIDGLISFNSKPLRMMIYLGLF
N315 FSKGLFEWIGYNTKVFTYQNVERQKGESKWSFKKLFNYGIDGLISFNSKPLRMMIYLGLF
NCTC8325 FSKGLFEWIGYNTKVFTYQNVERQKGESKWSFKKLFNYGIDGLISFNSKPLRMMIYLGLF
Newman FSKGLFEWIGYNTKVFTYQNVERQKGESKWSFKKLFNYGIDGLISFNSKPLRMMIYLGLF
USA300_FPR3757 FSKGLFEWIGYNTKVFTYQNVERQKGESKWSFKKLFNYGIDGLISFNSKPLRMMIYLGLF
************************************************************
COL IFSISVLYIIYLFINIMISGVNIPGYFSTIAAILLLGGIQLISIGVVGEYIGRIYYEVKA
N315 IFSISALYIIYLFINIMISGVNIPGYFSTIAAILLLGGIQLISIGVVGEYIGRIYYEVKA
NCTC8325 IFSISVLYIIYLFINIMISGVNIPGYFSTIAAILLLGGIQLISIGVVGEYIGRIYYEVKA
Newman IFSISVLYIIYLFINIMISGVNIPGYFSTIAAILLLGGIQLISIGVVGEYIGRIYYEVKA
USA300_FPR3757 IFSISVLYIIYLFINIMISGVNIPGYFSTIAAILLLGGIQLISIGVVGEYIGRIYYEVKA
*****.******************************************************
COL RPKYIIQATNLSSLENDEKDTHKVYSK
N315 RPKYIIQATNLSSIENDEKDTHKVYSK
NCTC8325 RPKYIIQATNLSSLENDEKDTHKVYSK
Newman RPKYIIQATNLSSLENDEKDTHKVYSK
USA300_FPR3757 RPKYIIQATNLSSLENDEKDTHKVYSK
*************:*************
- ↑ Kelvin Kho, Timothy C Meredith
Salt-Induced Stress Stimulates a Lipoteichoic Acid-Specific Three-Component Glycosylation System in Staphylococcus aureus.
J Bacteriol: 2018, 200(12);
[PubMed:29632092] [WorldCat.org] [DOI] (I e)