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⊟Summary[edit | edit source]

  • pan ID?: SAUPAN002642000
  • symbol?: murB
  • synonym:
  • description?: UDP-N-acetylenolpyruvoylglucosamine reductase

      descriptions from strain specific annotations:

    • UDP-N-acetylenolpyruvoylglucosamine reductase
    • UDP-N-acetylenolpyruvoylglucosamine reductase, putative
    • UDP-N-acetylmuramate dehydrogenase
    • putative UDP-N-acetylenolpyruvoylglucosaminereductase
  • strand?: -
  • coordinates?: 3142001..3142924
  • synteny block?: BlockID0018770
  • occurrence?: in 100% of 33 strains

murB : UDP-N-acetylenolpyruvoylglucosamine reductase [1]

• A crystal structure is available: 1HSK

⊟Orthologs[edit | edit source]

    COL:
    SACOL0801 (murB)
    N315:
    SA0693 (murB)
    NCTC8325:
    SAOUHSC_00752 (murB)
    Newman:
    NWMN_0707 (murB)
    USA300_FPR3757:
    SAUSA300_0722 (murB)
    04-02981:
    SA2981_0716
    08BA02176:
    C248_0825 (murB)
    11819-97:
    MS7_0788 (murB)
    6850:
    RSAU_000713 (murB)
    71193:
    ST398NM01_0814
    ECT-R 2:
    ECTR2_688 (murB)
    ED133:
    SAOV_0775c
    ED98:
    SAAV_0700 (murB)
    HO 5096 0412:
    SAEMRSA15_06640 (murB)
    JH1:
    SaurJH1_0779 (murB)
    JH9:
    SaurJH9_0762 (murB)
    JKD6008:
    SAA6008_00752 (murB)
    JKD6159:
    SAA6159_00693 (murB)
    LGA251:
    SARLGA251_06710 (murB)
    M013:
    M013TW_0723
    MRSA252:
    SAR0792 (murB)
    MSHR1132:
    SAMSHR1132_06830
    MSSA476:
    SAS0703 (murB)
    Mu3:
    SAHV_0735 (murB)
    Mu50:
    SAV0738 (murB)
    MW2:
    MW0700 (murB)
    RF122:
    SAB0690c (murB)
    ST398:
    SAPIG0814 (murB)
    T0131:
    SAT0131_00810
    TCH60:
    HMPREF0772_12446 (murB)
    TW20:
    SATW20_08130 (murB)
    USA300_TCH1516:
    USA300HOU_0764 (murB)
    VC40:
    SAVC_03325 (murB)

⊟Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
    N315            MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
    NCTC8325        MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
    Newman          MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
    USA300_FPR3757  MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
                    ************************************************************

    COL             IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVALDYALT
    N315            IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIDVSDDAIIAGSGAAIIDVSRVARDYALT
    NCTC8325        IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
    Newman          IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
    USA300_FPR3757  IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
                    ********************************:********************* *****

    COL             GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
    N315            GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
    NCTC8325        GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
    Newman          GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
    USA300_FPR3757  GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
                    ************************************************************

    COL             QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
    N315            QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
    NCTC8325        QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
    Newman          QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
    USA300_FPR3757  QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
                    ************************************************************

    COL             QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
    N315            QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
    NCTC8325        QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
    Newman          QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
    USA300_FPR3757  QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
                    ************************************************************

    COL             GEHPKES
    N315            GEHPKES
    NCTC8325        GEHPKES
    Newman          GEHPKES
    USA300_FPR3757  GEHPKES
                    *******

  1. ↑ Satoshi Nishida, Kenji Kurokawa, Miki Matsuo, Kimitoshi Sakamoto, Kohji Ueno, Kiyoshi Kita, Kazuhisa Sekimizu
    Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureus.
    J Biol Chem: 2006, 281(3);1714-24
    [PubMed:16236703] [WorldCat.org] [DOI] (P p)    Miki Matsuo, Kenji Kurokawa, Satoshi Nishida, Yan Li, Haruto Takimura, Chikara Kaito, Norio Fukuhara, Hideki Maki, Kenji Miura, Kazuhisa Murakami, Kazuhisa Sekimizu
    Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus.
    FEMS Microbiol Lett: 2003, 222(1);107-13
    [PubMed:12757953] [WorldCat.org] [DOI] (P p)    M S Harris, J T Herberg, J I Cialdella, J P Martin, T E Benson, G H Choi, E T Baldwin
    Crystallization and preliminary X-ray analysis of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureus.
    Acta Crystallogr D Biol Crystallogr: 2001, 57(Pt 7);1032-5
    [PubMed:11418774] [WorldCat.org] [DOI] (P p)    T E Benson, M S Harris, G H Choi, J I Cialdella, J T Herberg, J P Martin, E T Baldwin
    A structural variation for MurB: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB).
    Biochemistry: 2001, 40(8);2340-50
    [PubMed:11327854] [WorldCat.org] [DOI] (P p)
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