PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

⊟Summary

• pan ID^?: SAUPAN002791000
• symbol^?: vwb
• synonym:
• description^?: coagulase

  descriptions from strain specific annotations:

  • coagulase
  • putative staphylocoagulase
  • secreted von Willebrand factor-binding protein precursor
  • staphylocoagulase-like precursor, putative
  • staphylocoagulase precursor
  • truncated secreted von Willebrand factor-binding protein (coagulase) VWbp
  • von Willebrand factor binding protein Vwb
  • pseudogene
  • putative secreted von Willebrand factor-binding protein
  • secreted von Willebrand factor-binding protein
  • secreted von Willebrand factor-binding protein-like protein
  • Secreted von Willebrand factor-binding protein VWbp hypothetical protein
  • staphylocoagulase precursor (cell-bound form of staphylocoagulase)
  • staphylocoagulase precursor, Coa_1
  • Staphylococcus aureus subsp. aureus ECT-R 2 coagulase family protein
  • truncated secreted von Willebrand factor-binding protein VWbp
• strand^?: +
• coordinates^?: 3260483..3262576
• synteny block^?: BlockID0019850
• occurrence^?: in 79% of 33 strains

⊟Orthologs

COL:
SACOL0857
N315:
SA0743
NCTC8325:
SAOUHSC_00814
Newman:
NWMN_0757
USA300_FPR3757:
SAUSA300_0773
04-02981:
SA2981_0767
08BA02176:
—
11819-97:
MS7_0840
6850:
RSAU_000766
71193:
—
ECT-R 2:
ECTR2_740
ED133:
SAOV_0829
ED98:
SAAV_0758
HO 5096 0412:
—
JH1:
SaurJH1_0829
JH9:
SaurJH9_0813
JKD6008:
SAA6008_00804
JKD6159:
SAA6159_00744 (coa_1)
LGA251:
SARLGA251_07200
M013:
—
MRSA252:
SAR0843
MSHR1132:
—
MSSA476:
SAS0753
Mu3:
SAHV_0808 (graB)
Mu50:
SAV0812
MW2:
MW0766
RF122:
—
ST398:
—
T0131:
SAT0131_00888
TCH60:
HMPREF0772_12390
TW20:
SATW20_08630
USA300_TCH1516:
USA300HOU_0820 (vwb)
VC40:
SAVC_03590

⊟Genome Viewer

COL
N315
NCTC8325
Newman
USA300_FPR3757

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
  
  
  COL             MKNKLLVLSLGALCVSQIWESNRASAVVSGEKNPYVSESLKLTNNKNKSRTVEEYKKSLD
  N315            MKNKLLVLSLGALCVSQIWESNHASAVVSGEKNPYVSKALELKDKSNKSNSYENYRDSLE
  NCTC8325        ----------------------------------------------------------MD
  Newman          MKNKLLVLSLGALCVSQIWESNRASAVVSGEKNPYVSESLKLTNNKNKSRTVEEYKKSLD
  USA300_FPR3757  MKNKLLVLSLGALCVSQIWESNRASAVVSGEKNPYVSESLKLTNNKNKSRTVEEYKKSLD
                                                                            ::
  
  COL             DLIWSFPNLDNERFDNPEYKEAMKKYQQRFMAEDEALKKFFSEEKKIKNGNTD--NLDYL
  N315            SLISSLSFADYEKYEEPEYEKAVKKYQQKFMAEDDALKNFLNEEKKIKNADISRKSNNLL
  NCTC8325        DLIWSFPNLDNERFDNPEYKEAMKKYQQRFMAEDEALKKFFSEEKKIKNGNTD--NLDYL
  Newman          DLIWSFPNLDNERFDNPEYKEAMKKYQQRFMAEDEALKKFFSEEKKIKNGNTD--NLDYL
  USA300_FPR3757  DLIWSFPNLDNERFDNPEYKEAMKKYQQRFMAEDEALKKFFSEEKKIKNGNTD--NLDYL
                  .** *:.  * *::::***::*:*****:*****:***:*:.*******.: .  . : *
  
  COL             GLSHERYESVFNTLKKQSEEFLKEIEDIKKDNPELKDFNEEEQLKCDLELNKLENQILML
  N315            GLTHERYSYIFDTLKKNKQEFLKDIEEIQLKNSDLKDFNNTEQHNADVEINNLENKVLMV
  NCTC8325        GLSHERYESVFNTLKKQSEEFLKEIEDIKKDNPELKDFNEEEQLKCDLELNKLENQILML
  Newman          GLSHERYESVFNTLKKQSEEFLKEIEDIKKDNPELKDFNEEEQLKCDLELNKLENQILML
  USA300_FPR3757  GLSHERYESVFNTLKKQSEEFLKEIEDIKKDNPELKDFNEEEQLKCDLELNKLENQILML
                  **:****. :*:****:.:****:**:*: .*.:*****: ** :.*:*:*:***::**:
  
  COL             GKTFYQNYRDDVESLYSKLDLIMGYKDEERANKKAVNKRMLENKKEDLETIIDEFFSDID
  N315            GYTFYNTNKDEVEELYSELDLIVGEVQDKSDKKRAVNQRMLNRKKEDLEFIIDKFFKKIQ
  NCTC8325        GKTFYQNYRDDVESLYSKLDLIMGYKDEERANKKAVNKRMLENKKEDLETIIDEFFSDID
  Newman          GKTFYQNYRDDVESLYSKLDLIMGYKDEERANKKAVNKRMLENKKEDLETIIDEFFSDID
  USA300_FPR3757  GKTFYQNYRDDVESLYSKLDLIMGYKDEERANKKAVNKRMLENKKEDLETIIDEFFSDID
                  * ***:. :*:**.***:****:*  :::  :*:***:***:.****** ***:**..*:
  
  COL             KTRPNNIPVLEDEKQEEKNHKNMAQLKSDTEAAKSDESKRSKRSKRSLNTQNHKPASQEV
  N315            QERPESIPALTSEKNH--NQTMALKLKADTEAAKND---VSKRSKRSLNTQNNKSTTQEI
  NCTC8325        KTRPNNIPVLEDEKQEEKNHKNMAQLKSDTEAAKSDESKRSKRSKRSLNTQNHKPASQEV
  Newman          KTRPNNIPVLEDEKQEEKNHKNMAQLKSDTEAAKSDESKRSKRSKRSLNTQNHKPASQEV
  USA300_FPR3757  KTRPNNIPVLEDEKQEEKNHKNMAQLKSDTEAAKSDESKRSKRSKRSLNTQNHKPASQEV
                  : **:.**.* .**:.  *:.   :**:******.*    ************:*.::**:
  
  COL             SEQQKAEYDKRAEERKARFLDNQKIKKTPVVSLEYDFEHKQRIDNENDKKLVVSAPTKKP
  N315            SEEQKAEYQRKSEALKERFINRQKSKNESVVSLIDDED-----DNENDRQLVVSAPSKKP
  NCTC8325        SEQQKAEYDKRAEERKARFLDNQKIKKTPVVSLEYDFEHKQRIDNENDKKLVVSAPTKKP
  Newman          SEQQKAEYDKRAEERKARFLDNQKIKKTPVVSLEYDFEHKQRIDNENDKKLVVSAPTKKP
  USA300_FPR3757  SEQQKAEYDKRAEERKARFLDNQKIKKTPVVSLEYDFEHKQRIDNENDKKLVVSAPTKKP
                  **:*****::::*  * **::.** *: .****  * :     *****::******:***
  
  COL             TSPTTYTETTTQVPMPTVERQTQQQIIYNAPKQLAGLNGESHDFTTTHQSPTTSNHTHNN
  N315            TTPTTYTETTTQVPMPTVERQTQQQIVYKTPKPLAGLNGESHDFTTTHQSPTTSNHTHNN
  NCTC8325        TSPTTYTETTTQVPMPTVERQTQQQIIYNAPKQLAGLNGESHDFTTTHQSPTTSNHTHNN
  Newman          TSPTTYTETTTQVPMPTVERQTQQQIIYNAPKQLAGLNGESHDFTTTHQSPTTSNHTHNN
  USA300_FPR3757  TSPTTYTETTTQVPMPTVERQTQQQIIYNAPKQLAGLNGESHDFTTTHQSPTTSNHTHNN
                  *:************************:*::** ***************************
  
  COL             VVEFEETSALPGRKSGSLVGISQIDSSHLTEREKRVIKREHVREAQKLVDNYKDTHSYKD
  N315            VVEFEETSALPGRKSGSLVGISQIDSSHLTEREKRVIKREHVREAQKLVDNYKDTHSYKD
  NCTC8325        VVEFEETSALPGRKSGSLVGISQIDSSHLTEREKRVIKREHVREAQKLVDNYKDTHSYKD
  Newman          VVEFEETSALPGRKSGSLVGISQIDSSHLTEREKRVIKREHVREAQKLVDNYKDTHSYKD
  USA300_FPR3757  VVEFEETSALPGRKSGSLVGISQIDSSHLTEREKRVIKREHVREAQKLVDNYKDTHSYKD
                  ************************************************************
  
  COL             RINAQQKVNTLSEGHQKRFNKQINKVYNGK
  N315            RLNAQQKVNTLSEGHQKRFNKQINKVYNGK
  NCTC8325        RINAQQKVNTLSEGHQKRFNKQINKVYNGK
  Newman          RINAQQKVNTLSEGHQKRFNKQINKVYNGK
  USA300_FPR3757  RINAQQKVNTLSEGHQKRFNKQINKVYNGK
                  *:****************************