⊟Summary[edit | edit source]

pan ID^?: SAUPAN003031000
symbol^?: dltA
synonym:
description^?: D-alanine--poly(phosphoribitol) ligase subunit 1
- D-alanine--poly(phosphoribitol) ligase subunit 1
- D-alanine--poly(phosphoribitol) ligase
- D-alanine--poly(phosphoribitol) ligase subunit DltA
- D-alanine-activating enzyme
- D-alanine-activating enzyme/D-alanine-D-alanyl, dltA protein
- D-alanine--D-alanine ligase
- D-alanine--poly(phosphoribitol) ligase, subunit 1
strand^?: +
coordinates^?: 3421175..3422632
synteny block^?: BlockID0021390
occurrence^?: in 100% of 33 strains

dltA: D-alanine:carrier protein ligase ^[1]

A crystal structure is available: 7VHV

DltA is a part of the D-alanylation pathway of extracellular lipoteichoic acid modifications

• In the LTA D-alanylation pathway, D-alanine is activated (adenylylated) by DltA and thioesterified onto the phosphopantetheinylated carrier protein DltC. DltB transfers the D-alanine from DltC to an active site tyrosine of the acyl shuttle microprotein DltX and flips it to the outer leaflet of the membrane. Once on the outer leaflet, DltD can transfer the D-alanine from D-alanyl-DltX it to the 2-OH of the extracellular poly-glycerophosphate LTA.

• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.

⊟Orthologs[edit | edit source]

COL:

SACOL0935 (dltA)

N315:

SA0793 (dltA)

NCTC8325:

SAOUHSC_00869

Newman:

NWMN_0803 (dltA)

USA300_FPR3757:

SAUSA300_0835 (dltA)

04-02981:

SA2981_0887 (dltA)

08BA02176:

C248_0931 (dltA)

11819-97:

MS7_0887 (dltA)

6850:

RSAU_000809 (dltA)

71193:

ST398NM01_0915

ECT-R 2:

ECTR2_788 (dltA)

ED133:

SAOV_0878

ED98:

SAAV_0893 (dltA)

HO 5096 0412:

SAEMRSA15_07620 (dltA)

JH1:

SaurJH1_0951

JH9:

SaurJH9_0932

JKD6008:

SAA6008_00883 (dltA)

JKD6159:

SAA6159_00791 (dltA)

LGA251:

SARLGA251_08500 (dltA)

M013:

M013TW_0851

MRSA252:

SAR0894 (dltA)

MSHR1132:

SAMSHR1132_07840

MSSA476:

SAS0802

Mu3:

SAHV_0927 (dltA)

Mu50:

SAV0932 (dltA)

MW2:

MW0814 (dltA)

RF122:

SAB0798 (dltA)

ST398:

SAPIG0915 (dltA)

T0131:

SAT0131_00962

TCH60:

HMPREF0772_12315 (dltA)

TW20:

SATW20_09320 (dltA)

USA300_TCH1516:

USA300HOU_0893 (dltA)

VC40:

SAVC_03835

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
N315            MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
NCTC8325        MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
Newman          MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
USA300_FPR3757  MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
                ************************************************************

COL             MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
N315            MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
NCTC8325        MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
Newman          MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
USA300_FPR3757  MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
                ************************************************************

COL             KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQW
N315            KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNKQQW
NCTC8325        KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQW
Newman          KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQW
USA300_FPR3757  KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQW
                ********************************************************:***

COL             LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEM
N315            LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEM
NCTC8325        LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEM
Newman          LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEM
USA300_FPR3757  LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEM
                ************************************************************

COL             CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQI
N315            CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQI
NCTC8325        CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQI
Newman          CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQI
USA300_FPR3757  CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVNRFPSATIYNTYGPTEATVAVTSIQI
                **********************************.*************************

COL             TQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
N315            TQEILDQYPTLPVGVERLGARLSTTDDGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
NCTC8325        TQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
Newman          TQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
USA300_FPR3757  TQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
                ***************** ********:*********************************

COL             YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
N315            YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
NCTC8325        YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
Newman          YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
USA300_FPR3757  YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
                ************************************************************

COL             IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
N315            IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
NCTC8325        IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
Newman          IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
USA300_FPR3757  IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
                ************************************************************

COL             EVING
N315            EVING
NCTC8325        EVING
Newman          EVING
USA300_FPR3757  EVING
                *****

↑ In Gyun Lee, Chiman Song, Seoyeong Yang, Hanul Jeon, Jingyeong Park, Hye Jin Yoon, Hookang Im, Sung Min Kang, Hyun Jong Eun, Bong Jin Lee
Structural and functional analysis of the D-alanyl carrier protein ligase DltA from Staphylococcus aureus Mu50.
Acta Crystallogr D Struct Biol: 2022, 78(Pt 4);424-434
[PubMed:35362466] [WorldCat.org] [DOI] (I p)Christopher Weidenmaier, Andreas Peschel, Volkhard A J Kempf, Natalie Lucindo, Michael R Yeaman, Arnold S Bayer
DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.
Infect Immun: 2005, 73(12);8033-8
[PubMed:16299297] [WorldCat.org] [DOI] (P p)

[1] In Gyun Lee, Chiman Song, Seoyeong Yang, Hanul Jeon, Jingyeong Park, Hye Jin Yoon, Hookang Im, Sung Min Kang, Hyun Jong Eun, Bong Jin Lee
Structural and functional analysis of the D-alanyl carrier protein ligase DltA from Staphylococcus aureus Mu50.
Acta Crystallogr D Struct Biol: 2022, 78(Pt 4);424-434
[PubMed:35362466] [WorldCat.org] [DOI] (I p)Christopher Weidenmaier, Andreas Peschel, Volkhard A J Kempf, Natalie Lucindo, Michael R Yeaman, Arnold S Bayer
DltABCD- and MprF-mediated cell envelope modifications of Staphylococcus aureus confer resistance to platelet microbicidal proteins and contribute to virulence in a rabbit endocarditis model.
Infect Immun: 2005, 73(12);8033-8
[PubMed:16299297] [WorldCat.org] [DOI] (P p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]