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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003173000
- symbol?: yjbH
- synonym:
- description?: DsbA family protein
- DsbA family protein
- dithiol-disulfide isomerase, putative
- protein (Fragment)
- putative dithiol-disulfide isomerase
- YjbH-like, GTP pyrophosphokinase domain-containing protein
- YjbH-like, GTP pyrophosphokinase domain protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 3565440..3566225
- synteny block?: BlockID0022600
- occurrence?: in 100% of 33 strains
yjbH (dsbA): ClpXP substrate-recognition adaptor protein [1]
Under normal conditions, stress-induced regulator Spx is targeted for proteolysis by YjbH-augmented ClpXP. Under conditions of redox or other stresses, YjbH self-aggregates, Spx is no longer proteolyzed and it binds the alpha subunit of RNA polymerase where it enhances binding to extended -44 promoter elements.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_0956 (yjbH)
08BA02176:
C248_1024
11819-97:
MS7_0957
6850:
RSAU_000880
71193:
ST398NM01_0997
ECT-R 2:
ECTR2_856
ED133:
SAOV_0947c
ED98:
SAAV_0964
HO 5096 0412:
SAEMRSA15_08320
JH1:
SaurJH1_1019
JH9:
SaurJH9_1000
JKD6008:
SAA6008_00955
JKD6159:
SAA6159_00858
LGA251:
SARLGA251_09170
M013:
M013TW_0924
MRSA252:
SAR0969
MSHR1132:
SAMSHR1132_08490
MSSA476:
SAS0871
Mu3:
SAHV_0996 (yjbM)
Mu50:
SAV1001 (yjbM)
MW2:
MW0883
RF122:
SAB0868c
ST398:
SAPIG0997
T0131:
SAT0131_01037
TCH60:
HMPREF0772_12235
TW20:
SATW20_09990
USA300_TCH1516:
USA300HOU_0959
VC40:
SAVC_04175
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAGELRIMENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHI
N315 -------MENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHI
NCTC8325 MAGELRIMENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHI
Newman MAGELRIMENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHI
USA300_FPR3757 MAGELRIMENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHI
*****************************************************
COL LNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRVERFIHLMQNEIIPKRDIITESMI
N315 LNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRAERFIHLMQNEIIPKRDIITESMI
NCTC8325 LNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRAERFIHLMQNEIIPKRDIITESMI
Newman LNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRAERFIHLMQNEIIPKRDIITESMI
USA300_FPR3757 LNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRAERFIHLMQNEIIPKRDIITESMI
************************************.***********************
COL CDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVE
N315 CDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVE
NCTC8325 CDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVE
Newman CDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVE
USA300_FPR3757 CDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVE
************************************************************
COL GLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKK
N315 GLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKK
NCTC8325 GLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKK
Newman GLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKK
USA300_FPR3757 GLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKK
************************************************************
COL LAIQQKIEKLKYPDGDFWKSKMPKIKSK
N315 LAIQQKIEKLKYPDGDFWKSKMPKIKSK
NCTC8325 LAIQQKIEKLKYPDGDFWKSKMPKIKSK
Newman LAIQQKIEKLKYPDGDFWKSKMPKIKSK
USA300_FPR3757 LAIQQKIEKLKYPDGDFWKSKMPKIKSK
****************************
- ↑ Crystal M Austin, Siamak Garabaglu, Christina N Krute, Miranda J Ridder, Nichole A Seawell, Mary A Markiewicz, Jeffrey M Boyd, Jeffrey L Bose
Contribution of YjbIH to Virulence Factor Expression and Host Colonization in Staphylococcus aureus.
Infect Immun: 2019, 87(6);
[PubMed:30885928] [WorldCat.org] [DOI] (I e)Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Tom Grunert, Kazuhisa Sekimizu
YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus.
Virulence: 2021, 12(1);470-480
[PubMed:33487122] [WorldCat.org] [DOI] (I p)Tobias Krogh Nielsen, Ida Birkjær Petersen, Lijuan Xu, Maria Disen Barbuti, Viktor Mebus, Anni Justh, Abdulelah Ahmed Alqarzaee, Nicolas Jacques, Cécile Oury, Vinai Thomas, Morten Kjos, Camilla Henriksen, Dorte Frees
The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant Staphylococcus aureus.
Antimicrob Agents Chemother: 2024, 68(6);e0033524
[PubMed:38690894] [WorldCat.org] [DOI] (I p)Aubrey K G McReynolds, Emma A Pagella, Miranda J Ridder, Olivia Rippee, Zachary Clark, Michaella J Rekowski, Michele T Pritchard, Jeffrey L Bose
YjbH contributes to Staphylococcus aureus skin pathology and immune response through Agr-mediated α-toxin regulation.
Virulence: 2024, 15(1);2399798
[PubMed:39229975] [WorldCat.org] [DOI] (I p)Jakob Engman, Annika Rogstam, Dorte Frees, Hanne Ingmer, Claes von Wachenfeldt
The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus.
J Bacteriol: 2012, 194(5);1186-94
[PubMed:22194450] [WorldCat.org] [DOI] (I p)Olesya O Panasenko, Fedor Bezrukov, Olga Komarynets, Adriana Renzoni
YjbH Solubility Controls Spx in Staphylococcus aureus: Implication for MazEF Toxin-Antitoxin System Regulation.
Front Microbiol: 2020, 11;113
[PubMed:32117138] [WorldCat.org] [DOI] (P e)