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Summary[edit | edit source]

  • pan ID?: SAUPAN003351000
  • symbol?: rsmD
  • synonym:
  • description?: methyltransferase

      descriptions from strain specific annotations:

    • methyltransferase
    • 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD
    • S-adenosylmethionine-dependent methyltransferase, putative
    • Ribosomal RNA small subunit methyltransferase D
    • site-specific DNA-methyltransferase (adenine-specific)
    • methyltransferase small domain-containing protein
    • putative methylase
    • RNA methyltransferase, RsmD family
    • RsmD family RNA methyltransferase
  • strand?: +
  • coordinates?: 3717696..3718247
  • synteny block?: BlockID0024350
  • occurrence?: in 100% of 34 strains

rsmD : ribosome small subunit methyltransferase D [1]

Ribosome small subunit methyltransferase D (alt: ribosome small subunit nucleobase methyltransferase D, 16S rRNA guanine (975)-N(2)-methyltransferase) attaches a methyl group to the guanine nucleobase at the 2-position of residue 975 in 16S ribosomal RNA (S. aureus numbering; guanine 966 by E. coli numbering).

  • 16S rRNA : G (975) → m2G (975)

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_1080
    08BA02176:
    C248_1150
    11819-97:
    MS7_1080
    6850:
    RSAU_001008
    71193:
    ST398NM01_1120
    ECT-R 2:
    ECTR2_978
    ED133:
    SAOV_1065
    ED98:
    SAAV_1090
    HO 5096 0412:
    SAEMRSA15_09530
    JH1:
    SaurJH1_1205
    JH9:
    SaurJH9_1183
    JKD6008:
    SAA6008_01078
    JKD6159:
    SAA6159_00978
    JSNZ:
    JSNZ_001088 (rsmD)
    LGA251:
    SARLGA251_10360
    M013:
    M013TW_1055
    MRSA252:
    SAR1097
    MSHR1132:
    SAMSHR1132_09700
    MSSA476:
    SAS1058
    Mu3:
    SAHV_1115
    Mu50:
    SAV1124
    MW2:
    MW1006
    RF122:
    SAB0988
    ST398:
    SAPIG1120 (rsmD)
    T0131:
    SAT0131_01162
    TCH60:
    HMPREF0772_12109
    TW20:
    SATW20_11180
    USA300_TCH1516:
    USA300HOU_1061
    VC40:
    SAVC_04780

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MRVIAGKHKSKALESMEGRNTRPTMDKVKEGIFNSLYDVSGIGLDLFAGSGALGIEALSR
    N315            MRVIAGKHKSKALESMEGRNTRPTMDKVKEGIFNSLYDVSGIGLDLFAGSGALGIEALSR
    NCTC8325        ------------------------MDKVKEGIFNSLYDVSGIGLDLFAGSGALGIEALSR
    Newman          MRVIAGKHKSKALESMEGRNTRPTMDKVKEGIFNSLYDVSGIGLDLFAGSGALGIEALSR
    USA300_FPR3757  MRVIAGKHKSKALESMEGRNTRPTMDKVKEGIFNSLYDVSGIGLDLFAGSGALGIEALSR
                                            ************************************

    COL             GMDKVIFVDQNFKAVKVIKSNLANLDLEAQSEVYKNNADRALKALSKRDIQFDVIFLDPP
    N315            GMDKVIFVDQNFKAVKVIKSNLANLDLEAQSEVYKNNADRALKALSKRDIQFDVIFLDPP
    NCTC8325        GMDKVIFVDQNFKAVKVIKSNLANLDLEAQSEVYKNNADRALKALSKRDIQFDVIFLDPP
    Newman          GMDKVIFVDQNFKAVKVIKSNLANLDLEAQSEVYKNNADRALKALSKRDIQFDVIFLDPP
    USA300_FPR3757  GMDKVIFVDQNFKAVKVIKSNLANLDLEAQSEVYKNNADRALKALSKRDIQFDVIFLDPP
                    ************************************************************

    COL             YNKGLIDKALKLISEFNLLKENGIIVCEFSNHEEIDYQPFNMIKRYHYGLTDTLLLEKGE
    N315            YNKGLIDKALKLISEFNLLKENGIIVCEFSNHEEIDYQPFNMIKRYHYGLTDTLLLEKGE
    NCTC8325        YNKGLIDKALKLISEFNLLKENGIIVCEFSNHEEIDYQPFNMIKRYHYGLTDTLLLEKGE
    Newman          YNKGLIDKALKLISEFNLLKENGIIVCEFSNHEEIDYQPFNMIKRYHYGLTDTLLLEKGE
    USA300_FPR3757  YNKGLIDKALKLISEFNLLKENGIIVCEFSNHEEIDYQPFNMIKRYHYGLTDTLLLEKGE
                    ************************************************************

  1. Geoffrey S Briggs, Wiep Klaas Smits, Panos Soultanas
    Chromosomal replication initiation machinery of low-G+C-content Firmicutes.
    J Bacteriol: 2012, 194(19);5162-70
    [PubMed:22797751] [WorldCat.org] [DOI] (I p)
    Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
    Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
    FEBS Lett: 2020, 594(21);3551-3567
    [PubMed:32852796] [WorldCat.org] [DOI] (I p)
    Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
    Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
    Sci Rep: 2024, 14(1);14253
    [PubMed:38902339] [WorldCat.org] [DOI] (I e)