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Summary[edit | edit source]

  • pan ID?: SAUPAN003405000
  • symbol?: scc
  • synonym:
  • description?: fibrinogen-binding protein

      descriptions from strain specific annotations:

    • fibrinogen-binding protein
    • complement inhibitor SCIN-B
    • complement inhibitor SCIN family protein
    • fibrinogen-binding protein precursor-like protein
    • Staphylococcal complement inhibitor SCIN-like protein
    • fibrinogen-binding protein precursor-related protein
    • Involved in expression of fibrinogen binding protein
    • staphylococcal complement inhibitor (SCIN)
  • strand?: +
  • coordinates?: 3760783..3761133
  • synteny block?: BlockID0024860
  • occurrence?: in 97% of 34 strains

scnB (scb) : staphylococcal complement C3 convertase inhibitor SCIN-B [1]

• A crystal structure is available : 3T49

Complement inhibitor SCIN-B is an immune factor found in the core staphylococcal genome and a contributor to human pathogenic potential. SCIN-B specifically inhibits C3 convertase, preventing complement cascade activation. Although both prophage-encoded SCIN-A and core genome-encoded SCIN-B can inhibit C3 convertase, SCIN-A appears to provide a greater contribution to virulence, potentially due to its more robust (and inducible) expression and more specific C3 convertase binding.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    SA2981_1115
    08BA02176:
    C248_1187
    11819-97:
    MS7_1115
    6850:
    RSAU_001041
    71193:
    ST398NM01_1155
    ECT-R 2:
    ECTR2_1013
    ED133:
    SAOV_1156
    ED98:
    SAAV_1127
    HO 5096 0412:
    SAEMRSA15_09900
    JH1:
    SaurJH1_1240
    JH9:
    SaurJH9_1216
    JKD6008:
    SAA6008_01112 (scc)
    JKD6159:
    SAA6159_01011 (scc)
    JSNZ:
    JSNZ_001125 (scb)
    LGA251:
    SARLGA251_10690 (scc)
    M013:
    M013TW_1091
    MRSA252:
    SAR1131
    MSHR1132:
    MSSA476:
    SAS1092
    Mu3:
    SAHV_1149
    Mu50:
    SAV1159
    MW2:
    MW1041
    RF122:
    SAB1022
    ST398:
    SAPIG1155
    T0131:
    SAT0131_01202 (rpmD)
    TCH60:
    HMPREF0772_12075
    TW20:
    SATW20_11510 (scc)
    USA300_TCH1516:
    USA300HOU_1095
    VC40:
    SAVC_04950

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
    N315            MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
    NCTC8325        MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
    Newman          MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
    USA300_FPR3757  MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
                    ************************************************************

    COL             VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
    N315            VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
    NCTC8325        VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
    Newman          VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
    USA300_FPR3757  VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
                    ********************************************************

  1. Ilse Jongerius, Jörg Köhl, Manoj K Pandey, Maartje Ruyken, Kok P M van Kessel, Jos A G van Strijp, Suzan H M Rooijakkers
    Staphylococcal complement evasion by various convertase-blocking molecules.
    J Exp Med: 2007, 204(10);2461-71
    [PubMed:17893203] [WorldCat.org] [DOI] (P p)
    Brandon L Garcia, Kasra X Ramyar, Daniel Ricklin, John D Lambris, Brian V Geisbrecht
    Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.
    Adv Exp Med Biol: 2012, 946;113-33
    [PubMed:21948365] [WorldCat.org] [DOI] (P p)
    Brandon L Garcia, Brady J Summers, Zhuoer Lin, Kasra X Ramyar, Daniel Ricklin, Divya V Kamath, Zheng-Qing Fu, John D Lambris, Brian V Geisbrecht
    Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.
    J Biol Chem: 2012, 287(1);628-640
    [PubMed:22086928] [WorldCat.org] [DOI] (I p)
    Andi R Sultan, Jasper W Swierstra, Nicole A Lemmens-den Toom, Susan V Snijders, Silvie Hansenová Maňásková, Annelies Verbon, Willem J B van Wamel
    Production of Staphylococcal Complement Inhibitor (SCIN) and Other Immune Modulators during the Early Stages of Staphylococcus aureus Biofilm Formation in a Mammalian Cell Culture Medium.
    Infect Immun: 2018, 86(8);
    [PubMed:29784858] [WorldCat.org] [DOI] (I e)