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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003405000
- symbol?: scc
- synonym:
- description?: fibrinogen-binding protein
- fibrinogen-binding protein
- complement inhibitor SCIN-B
- complement inhibitor SCIN family protein
- fibrinogen-binding protein precursor-like protein
- Staphylococcal complement inhibitor SCIN-like protein
- fibrinogen-binding protein precursor-related protein
- Involved in expression of fibrinogen binding protein
- staphylococcal complement inhibitor (SCIN)
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3760783..3761133
- synteny block?: BlockID0024860
- occurrence?: in 97% of 34 strains
scnB (scb) : staphylococcal complement C3 convertase inhibitor SCIN-B [1]
• A crystal structure is available : 3T49
Complement inhibitor SCIN-B is an immune factor found in the core staphylococcal genome and a contributor to human pathogenic potential. SCIN-B specifically inhibits C3 convertase, preventing complement cascade activation. Although both prophage-encoded SCIN-A and core genome-encoded SCIN-B can inhibit C3 convertase, SCIN-A appears to provide a greater contribution to virulence, potentially due to its more robust (and inducible) expression and more specific C3 convertase binding.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1115
08BA02176:
C248_1187
11819-97:
MS7_1115
6850:
RSAU_001041
71193:
ST398NM01_1155
ECT-R 2:
ECTR2_1013
ED133:
SAOV_1156
ED98:
SAAV_1127
HO 5096 0412:
SAEMRSA15_09900
JH1:
SaurJH1_1240
JH9:
SaurJH9_1216
JKD6008:
SAA6008_01112 (scc)
JKD6159:
SAA6159_01011 (scc)
JSNZ:
JSNZ_001125 (scb)
LGA251:
SARLGA251_10690 (scc)
M013:
M013TW_1091
MRSA252:
SAR1131
MSHR1132:
—
MSSA476:
SAS1092
Mu3:
SAHV_1149
Mu50:
SAV1159
MW2:
MW1041
RF122:
SAB1022
ST398:
SAPIG1155
T0131:
SAT0131_01202 (rpmD)
TCH60:
HMPREF0772_12075
TW20:
SATW20_11510 (scc)
USA300_TCH1516:
USA300HOU_1095
VC40:
SAVC_04950
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
N315 MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
NCTC8325 MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
Newman MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
USA300_FPR3757 MKFKKYILTGTLALLLSSTGIATIEGNKADASSLDKYLTESQFHDKRIAEELRTLLNKSN
************************************************************
COL VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
N315 VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
NCTC8325 VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
Newman VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
USA300_FPR3757 VYALAAGSLNPYYKRTIMMNEYRAKAALKKNDFVSMADAKVALEKIYKEIDEIINR
********************************************************
- ↑ Ilse Jongerius, Jörg Köhl, Manoj K Pandey, Maartje Ruyken, Kok P M van Kessel, Jos A G van Strijp, Suzan H M Rooijakkers
Staphylococcal complement evasion by various convertase-blocking molecules.
J Exp Med: 2007, 204(10);2461-71
[PubMed:17893203] [WorldCat.org] [DOI] (P p)Brandon L Garcia, Kasra X Ramyar, Daniel Ricklin, John D Lambris, Brian V Geisbrecht
Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.
Adv Exp Med Biol: 2012, 946;113-33
[PubMed:21948365] [WorldCat.org] [DOI] (P p)Brandon L Garcia, Brady J Summers, Zhuoer Lin, Kasra X Ramyar, Daniel Ricklin, Divya V Kamath, Zheng-Qing Fu, John D Lambris, Brian V Geisbrecht
Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.
J Biol Chem: 2012, 287(1);628-640
[PubMed:22086928] [WorldCat.org] [DOI] (I p)Andi R Sultan, Jasper W Swierstra, Nicole A Lemmens-den Toom, Susan V Snijders, Silvie Hansenová Maňásková, Annelies Verbon, Willem J B van Wamel
Production of Staphylococcal Complement Inhibitor (SCIN) and Other Immune Modulators during the Early Stages of Staphylococcus aureus Biofilm Formation in a Mammalian Cell Culture Medium.
Infect Immun: 2018, 86(8);
[PubMed:29784858] [WorldCat.org] [DOI] (I e)