⊟Summary[edit | edit source]

pan ID^?: SAUPAN003534000
symbol^?: —
synonym:
description^?: membrane protein
- membrane protein
- lipoteichoic acid-specific glycosyltransferase YfhO
- YfhO family protein
- putative membrane protein YfhO
- integral membrane protein
- pseudogene
strand^?: -
coordinates^?: 3871625..3874231
synteny block^?: BlockID0026110
occurrence^?: in 100% of 34 strains

yfhO: lipoteichoic acid-specific N-acetylglucosamine glycosyltransferase ^[1]

YfhO is a part of the glycosylation pathway of extracellular lipoteichoic acid modifications

• In the LTA glycosylation pathway, CsbB transfers NAG to an undecaprenol carrier in the cytoplasm which traffics it to the inner leaflet of the cell membrane. GtcA flips it to the outer leaflet where YfhO can transfer NAG to the 2-OH of the extracellular poly-glycerophosphate LTA.

• Under high salt conditions, the alternate sigma factor SigB activates LTA glycosylation and represses LTA D-alanylation.

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

JSNZ:

JSNZ_001212 (yfhO)

04-02981:

SA2981_1200

08BA02176:

C248_1273

11819-97:

MS7_1200

6850:

RSAU_001124

71193:

ST398NM01_1242

ECT-R 2:

ECTR2_1098

ED133:

SAOV_1245c

ED98:

SAAV_1216

HO 5096 0412:

SAEMRSA15_10750

JH1:

SaurJH1_1326

JH9:

SaurJH9_1301

JKD6008:

SAA6008_01197 (yfhO)

JKD6159:

SAA6159_01097 (yfhO)

LGA251:

SARLGA251_11530

M013:

M013TW_1180

MRSA252:

SAR1218

MSHR1132:

SAMSHR1132_10850

MSSA476:

SAS1176

Mu3:

SAHV_1232

Mu50:

SAV1242

MW2:

MW1125

RF122:

SAB1106c

ST398:

SAPIG1242

T0131:

SAT0131_01292

TCH60:

HMPREF0772_11989

TW20:

SATW20_12360

USA300_TCH1516:

USA300HOU_1173

VC40:

SAVC_05375

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.505)

COL             MLKKWLNSNVKQFFVITFISVILTLILFSTHIYDYIVNGTVFSGAGDGFRQMMPFQMYLY
N315            MLKKWLNSNVKQFFVITFISVILTLILFSTHIYDYIVNGTVFSGAGDGFRQMMPFQMYLY
NCTC8325        MLKKWLNSNVKQFFVITFISVILTLILFSTHIYDYIVNGTVFSGAGDGFRQMMPFQMYLY
Newman          MLKKWLNSNVKQFFVITFISVILTLILFSTHIYDYIVNGTVFSGAGDGFRQMMPFQMYLY
USA300_FPR3757  MLKKWLNSNVKQFFVITFISVILTLILFSTHIYDYIVNGTVFSGAGDGFRQMMPFQMYLY
JSNZ            MLKKWLNSNVKQFFIITFISVILTLILFSTHIYDYIVNGTVFSGAGDGFRQMMPFQMYLY
                **************:*********************************************

COL             EHLRSFSSLYDASFGLGGDYMKGLSYYYSLSPLMWLNFLFIKIGETVGIFNPTTIHFWPT
N315            EHLSSFSSLYDASFGLGGDYMKGLSYYYSLSPLMWLNFLFIKIGETVGIFNPTTIHFWPT
NCTC8325        EHLRSFSSLYDASFGLGGDYMKGLSYYYSLSPLMWLNFLFIKIGETVGIFNPTTIHFWPT
Newman          EHLRSFSSLYDASFGLGGDYMKGLSYYYSLSPLMWLNFLFIKIGETVGIFNPTTIHFWPT
USA300_FPR3757  EHLRSFSSLYDASFGLGGDYMKGLSYYYSLSPLMWLNFLFIKIGETVGIFNPTTIHFWPT
JSNZ            EHLSSFSSLYDASFGLGGDYMKGLSYYYSLSPLMWLNFLFIKIGETVGIFNPTTIHFWPT
                *** ********************************************************

COL             NQLIMAMIRAIITFVVTFYLFKILHFKRSANMIATILYGMSTVVIYFNFTWSFYGNLLYL
N315            NQLIMAMIRAIITFVVTFYLFKILHFKRSTNMIATILYGMSTVVIYFNFTWSFYGNLLYL
NCTC8325        NQLIMAMIRAIITFVVTFYLFKILHFKRSANMIATILYGMSTVVIYFNFTWSFYGNLLYL
Newman          NQLIMAMIRAIITFVVTFYLFKILHFKRSANMIATILYGMSTVVIYFNFTWSFYGNLLYL
USA300_FPR3757  NQLIMAMIRAIITFVVTFYLFKILHFKRSANMIATILYGMSTVVIYFNFTWSFYGNLLYL
JSNZ            NQLIMAMIRAIITFVVTFYLFKILHFKRSTNMIATILYGMSTVVIYFNFTWSFYGNLLYL
                *****************************:******************************

COL             LPLSILGLERYFQQRKIGIFIVAIALTLFSNFYFSYYQAIIIGCYYLYRLIFTYKYDIVS
N315            LPLSILGLERYFQQRKIGIFIVAIALTLFSNFYFSYYQAIIIGCYYLYRLIFTYKYDIVS
NCTC8325        LPLSILGLERYFQQRKIGIFIVAIALTLFSNFYFSYYQAIIIGCYYLYRLIFTYKYDIVS
Newman          LPLSILGLERYFQQRKIGIFIVAIALTLFSNFYFSYYQAIIIGCYYLYRLIFTYKYDIVS
USA300_FPR3757  LPLSILGLERYFQQRKIGIFIVAIALTLFSNFYFSYYQAIIIGCYYLYRLIFTYKYDIVS
JSNZ            LPLSILGLERYFQQRKIGIFIVAIALTLFSNFYFSYYQAIIIGCYYLYRLIFTYKYDIVS
                ************************************************************

COL             RTQKLICVISATVLSVLSSVFGLFTGISAFLENDRKQNPNVDIPFLTPLDYHYFFFSDGF
N315            RTQKFICVISATVLSVLSSVFGLFTGISAFLENDRKQNPNVDIPFLTPLDYHYFFFSDGF
NCTC8325        RTQKLICVISATVLSVLSSVFGLFTGISAFLENDRKQNPNVDIPFLTPLDYHYFFFSDGF
Newman          RTQKLICVISATVLSVLSSVFGLFTGISAFLENDRKQNPNVDIPFLTPLDYHYFFFSDGF
USA300_FPR3757  RTQKLICVISATVLSVLSSVFGLFTGISAFLENDRKQNPNVDIPFLTPLDYHYFFFSDGF
JSNZ            RTQKLICVISATVLSVLSSVFGLFTGISAFLENDRKQNPNVDIPFLTPLDYHYFFFSDGF
                ****:*******************************************************

COL             YITISILTIVALLSFKLYRFYFYRLFAIVTWILFIGSLSQYFDSAFNGFSFPERRWVYIL
N315            YITISILTIVALLSFKLYRFYFYRLFAIVTWILFIGSLSQYFDSAFNGFSFPERRWVYIL
NCTC8325        YITISILTIVALLSFKLYRFYFYRLFAIVTWILFIGSLSQYFDSAFNGFSFPERRWVYIL
Newman          YITISILTIVALLSFKLYRFYFYRLFAIVTWILFIGSLSQYFDSAFNGFSFPERRWVYIL
USA300_FPR3757  YITISILTIVALLSFKLYRFYFYRLFAIVTWILFIGSLSQYFDSAFNGFSFPERRWVYIL
JSNZ            YITISILTIVALLSFKLYRFYFYRLFAIVTWLLFIGSLSQYFDSAFNGFSFPERRWVYIL
                *******************************:****************************

COL             ALSSSALCGLFIQHLSTLNMKYYLIRTIPVCIIAILYVLLSPTHPLALIVGIILLIVLAV
N315            ALSSSALCGLFIQHLSTLNMKYYLIRTIPVSIIALLYVLLSPTHPLALIVGIILLMVLAV
NCTC8325        ALSSSALCGLFIQHLSTLNMKYYLIRTIPVCIIAILYVLLSPTHPLALIVGIILLIVLAV
Newman          ALSSSALCGLFIQHLSTLNMKYYLIRTIPVCIIAILYVLLSPTHPLALIVGIILLIVLAV
USA300_FPR3757  ALSSSALCGLFIQHLSTLNMKYYLIRTIPVCIIAILYVLLSPTHPLALIVGIILLIVLAV
JSNZ            ALSSSALCGLFIQHLSTLNMKYYLIRTIPVSIIALLYVLLSPTHPLALIVGIILLMVLAV
                ******************************.***:********************:****

COL             ILKFSLWRYKKLTVAILVLIVMIQQIVILDNNKNMAIKPYQQSLSTLKQHDYHSNYVNQL
N315            ILKFSLWRYKKLTVAILVLIVMIQQIVILDNNKNMAIKPYQQSLSTLKQHDYHSNYVNQL
NCTC8325        ILKFSLWRYKKLTVAILVLIVMIQQIVILDNNKNMAIKPYQQSLSTLKQHDYHSNYVNQL
Newman          ILKFSLWRYKKLTVAILVLIVMIQQIVILDNNKNMAIKPYQQSLSTLKQHDYHSNYVNQL
USA300_FPR3757  ILKFSLWRYKKLTVAILVLIVMIQQIVILDNNKNMAIKPYQQSLSTLKQHDYHSNYVNQL
JSNZ            ILKFSLWRYKKLTVAILVLIVMIQQIVILDNNKNMAIKPYQQSLSTLKQHDYHSNYVNQL
                ************************************************************

COL             IKKINQNATGSFNRIDYMSDYALNSPFIYHYNGISLYSSIFNGDILKYYDKTLQINMPID
N315            IKKINQNATGPFNRIDYMSDYALNSPFIYHYNGISLYSSIFNGDILKYYDKTLQINMPID
NCTC8325        IKKINQNATGSFNRIDYMSDYALNSPFIYHYNGISLYSSIFNGDILKYYDKTLQINMPID
Newman          IKKINQNATGSFNRIDYMSDYALNSPFIYHYNGISLYSSIFNGDILKYYDKTLQINMPID
USA300_FPR3757  IKKINQNATGSFNRIDYMSDYALNSPFIYHYNGISLYSSIFNGDILKYYDKTLQINMPID
JSNZ            IKKINQNATGPFNRIDYMSDYALNSPFIYHYNGISLYSSIFNGDILKYYDKTLQINMPID
                **********.*************************************************

COL             KNSTYRLLGNRQNLLSLWNVNDRIRVNHDDNLPYGFKIKSEHKDNKVRWIHSKNTIHYPS
N315            KNSTYRLLGNRQNLLSLWNVNDRIRVNHDDNLPYRFKINSEHKDNKVRWIHSKNTIHYPS
NCTC8325        KNSTYRLLGNRQNLLSLWNVNDRIRVNHDDNLPYGFKIKSEHKDNKVRWIHSKNTIHYPS
Newman          KNSTYRLLGNRQNLLSLWNVNDRIRVNHDDNLPYGFKIKSEHKDNKVRWIHSKNTIHYPS
USA300_FPR3757  KNSTYRLLGNRQNLLSLWNVNDRIRVNHDDNLPYGFKIKSEHKDNKVRWIHSKNTIHYPS
JSNZ            KNSTYRLLGNRQNLLSLWNVNDRIRVNHDDNLPYGFKIKSEHKDNKVRWIHSKNTIHYPS
                ********************************** ***:*********************

COL             AHITNKVFSNKELKSPLDKEQAMLQGIVSNNIKDVNTHFKANKNLLSDSTIKLNSAAWQS
N315            AHITNKVFSNKELKSPLDKEQAMLQGIVSNNTKDVNTHFKANKNLLSDSTIKLNSSAWQS
NCTC8325        AHITNKVFSNKELKSPLDKEQAMLQGIVSNNIKDVNTHFKANKNLLSDSTIKLNSAAWQS
Newman          AHITNKVFSNKELKSPLDKEQAMLQGIVSNNIKDVNTHFKANKNLLSDSTIKLNSAAWQS
USA300_FPR3757  AHITNKVFSNKELKSPLDKEQAMLQGIVSNNIKDVNTHFKANKNLLSDSTIKLNSAAWQS
JSNZ            AHITNKVFSNKELKSPLDKEQARLQGIVSNNTKDVNTHFKANKNLLSDSTIKLNSSAWQS
                ********************** ******** ***********************:****

COL             PTKHLLQVKQNNGGLTVQLPKSVSNQFKDLYFEMDLELLSPDKAHDVKVNEYTQERNKLT
N315            PTKHLLQVKQNNGGLTVQLPKSVSNQFKDLYFEMDLELLSPDKAHDVKVNEYTQERNKLT
NCTC8325        PTKHLLQVKQNNGGLTVQLPKSVSNQFKDLYFEMDLELLSPDKAHDVKVNEYTQERNKLT
Newman          PTKHLLQVKQNNGGLTVQLPKSVSNQFKDLYFEMDLELLSPDKAHDVKVNEYTQERNKLT
USA300_FPR3757  PTKHLLQVKQNNGGLTVQLPKSVSNQFKDLYFEMDLELLSPDKAHDVKVNEYTQERNKLT
JSNZ            PTKHLLQVKQNNGGLTVQLPKSVSNQFKDLYFEMDLELLSPDKAHDVKVNEYTQERNKLT
                ************************************************************

COL             YKYRRVVTPVTIRIKAPDRIRLSLPKGKYRVNLKGIYGEDYTTLKDASNSLEAVKVSKTK
N315            YKYRRFVTPVTIRIKASDRIRLSLPKGKYRVNLKGIYGEDYTTLKDASNSLEAVKVSKTK
NCTC8325        YKYRRVVTPVTIRIKAPDRIRLSLPKGKYRVNLKGIYGEDYTTLKDASNSLEAVKVSKTK
Newman          YKYRRVVTPVTIRIKAPDRIRLSLPKGKYRVNLKGIYGEDYTTLKDASNSLEAVKVSKTK
USA300_FPR3757  YKYRRVVTPVTIRIKAPDRIRLSLPKGKYRVNLKGIYGEDYTTLKDASNSLEAVKVSKTK
JSNZ            YKYRRFVTPVTIRIKASDRIRLSLPKGKYRVNLKGIYGEDYTTLKDASNSLEAVKVSKTK
                *****.**********.*******************************************

COL             HGYTITKNKNSSGYIVLPTAYNQGMKATSGDQSLKVEQVNGVMTGIKAPKNITKIQLSYT
N315            QGYTITKNKNSSGYIVLPTAYNQGMKATSGDQSLKVAQVNGVMTGIKAPKNITKIQLSYT
NCTC8325        HGYTITKNKNSSGYIVLPTAYNQGMKATSGDQSLKVEQVNGVMTGIKAPKNITKIQLSYT
Newman          HGYTITKNKNSSGYIVLPTAYNQGMKATSGDQSLKVEQVNGVMTGIKAPKNITKIQLSYT
USA300_FPR3757  HGYTITKNKNSSGYIVLPTAYNQGMKATSGDQSLKVEQVNGVMTGIKAPKNITKIQLSYT
JSNZ            QGYTITKNKNSSGYIVLPTAYNQGMKATSGDQSLKVEQVNGIMTGIKAPKNITKIQLSYT
                :*********************************** ****:******************

COL             PPYYYLLITITIFGIICSIIFTRWARQK
N315            PPYYYLLITITIFGIICSIIFTRWARQK
NCTC8325        PPYYYLLITITIFGIICSIIFTRWARQK
Newman          PPYYYLLITITIFGIICSIIFTRWARQK
USA300_FPR3757  PPYYYLLITITIFGIICSIIFTRWARQK
JSNZ            PPYYYLLITITIFGIICSIIFTRWARQK
                ****************************

↑ Kelvin Kho, Timothy C Meredith
Salt-Induced Stress Stimulates a Lipoteichoic Acid-Specific Three-Component Glycosylation System in Staphylococcus aureus.
J Bacteriol: 2018, 200(12);
[PubMed:29632092] [WorldCat.org] [DOI] (I e)

[1] Kelvin Kho, Timothy C Meredith
Salt-Induced Stress Stimulates a Lipoteichoic Acid-Specific Three-Component Glycosylation System in Staphylococcus aureus.
J Bacteriol: 2018, 200(12);
[PubMed:29632092] [WorldCat.org] [DOI] (I e)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757
JSNZ

Search

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]