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⊟Summary[edit | edit source]
- pan ID?: SAUPAN003623000
- symbol?: hflX
- synonym:
- description?: GTPase HflX
- GTPase HflX
- GTP-binding protein
- GTP-binding protein HflX, putative
- putative GTP-binding protein
- GTPase
- GTP-binding protein, putative
- GTP-binding proteinase modulator YnbA
- GTP-binding protein HflX
- GTP-binding protein HSR1-related
- GTP-binding proten HflX
- HSR1-like GTP-binding protein
descriptions from strain specific annotations:
- strand?: +
- coordinates?: 3960392..3961639
- synteny block?: BlockID0026930
- occurrence?: in 100% of 33 strains
hflX: 100S hibernation ribosome disassembly protein and ribosome-associated GTPase HflX [1]
Ribosome-associated GTPases including Era, RsgA, RbgA, HflX, ObgE, EngA and EngB are widely-conserved, stringent response alarmone-responsive ribosomal assembly cofactors
• HflX acts to disassemble heat-stalled 70S and 100S hibernation ribosomes. Alarmone binding prevents this action.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1263 (hflX)
08BA02176:
C248_1340
11819-97:
MS7_1263 (hflX)
6850:
RSAU_001189 (hflX)
71193:
ST398NM01_1308
ECT-R 2:
ECTR2_1163 (hflX)
ED133:
SAOV_1307
ED98:
SAAV_1280
HO 5096 0412:
SAEMRSA15_11400
JH1:
SaurJH1_1391
JH9:
SaurJH9_1365
JKD6008:
SAA6008_01260 (hflX)
JKD6159:
SAA6159_01160 (hflX)
LGA251:
SARLGA251_12160
M013:
M013TW_1247
MRSA252:
SAR1281
MSHR1132:
SAMSHR1132_11480
MSSA476:
SAS1239
Mu3:
SAHV_1296
Mu50:
SAV1307
MW2:
MW1189
RF122:
SAB1169
ST398:
SAPIG1308 (hflX)
T0131:
SAT0131_01362
TCH60:
HMPREF0772_11920 (hflX)
TW20:
SATW20_12990
USA300_TCH1516:
USA300HOU_1237
VC40:
SAVC_05725
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MAQQQIHDTKNKLEKAVLVGVHAQDDKQFNFESTMEELSSLSETCQLEVLGQITQNRDRV
N315 MAQQQIHDTKNKLEKAVLVGVHAQDDKQFNFESTMEELSSLSETCQLEVLGQITQNRDRV
NCTC8325 MAQQQIHDTKNKLEKAVLVGVHAQDDKQFNFESTMEELSSLSETCQLEVLGQITQNRDRV
Newman MAQQQIHDTKNKLEKAVLVGVHAQDDKQFNFESTMEELSSLSETCQLEVWVQITQNRDRV
USA300_FPR3757 MAQQQIHDTKNKLEKAVLVGVHAQDDKQFNFESTMEELSSLSETCQLEVLGQITQNRDRV
************************************************* *********
COL DRKYYVGKGKIEEIQAFIEFKDIDVVITNDELTTAQSKSLNEALGVKIIDRTQLILEIFA
N315 DRKYYVGKGKIEEIQAFIEFKDIDVVITNDELTTAQSKSLNEALGVKIIDRTQLILEIFA
NCTC8325 DRKYYVGKGKIEEIQAFIEFKDIDVVITNDELTTAQSKSLNEALGVKIIDRTQLILEIFA
Newman DRKYYVGKGKIEEIQAFIEFKDIDVVITNDELTTAQSKSLNEALGVKIIDRTQLILEIFA
USA300_FPR3757 DRKYYVGKGKIEEIQAFIEFKDIDVVITNDELTTAQSKSLNEALGVKIIDRTQLILEIFA
************************************************************
COL LRARSKEGKLQVELAQLDYLLPRLQGHGKSLSRLGGGIGTRGPGETKLEMDRRHIRTRMN
N315 LRARSKEGKLQVELAQLDYLLPRLQGHGKSLSRLGGGIGTRGPGETKLEMDRRHIRTRMN
NCTC8325 LRARSKEGKLQVELAQLDYLLPRLQGHGKSLSRLGGGIGTRGPGETKLEMDRRHIRTRMN
Newman LRARSKEGKLQVELAQLDYLLPRLQGHGKSLSRLGGGIGTRGPGETKLEMDRRHIRTRMN
USA300_FPR3757 LRARSKEGKLQVELAQLDYLLPRLQGHGKSLSRLGGGIGTRGPGETKLEMDRRHIRTRMN
************************************************************
COL EIKHQLRTVEEHRERYRNKRNQNQVFQVALVGYTNAGKSSWFNVLANEETYEKDQLFATL
N315 EIKHQLRTVEEHRERYRNKRNQNQVFQVALVGYTNAGKSSWFNVLANEETYEKDQLFATL
NCTC8325 EIKHQLRTVEEHRERYRNKRNQNQVFQVALVGYTNAGKSSWFNVLANEETYEKDQLFATL
Newman EIKHQLRTVEEHRERYRNKRNQNQVFQVALVGYTNAGKSSWFNVLANEETYEKDQLFATL
USA300_FPR3757 EIKHQLRTVEEHRERYRNKRNQNQVFQVALVGYTNAGKSSWFNVLANEETYEKDQLFATL
************************************************************
COL DPKTRQIQINDGFNLIISDTVGFIQKLPTTLIAAFKSTLEEAKGADLLVHVVDSSHPEYR
N315 DPKTRQIQINDGFNLIISDTVGFIQKLPTTLIAAFKSTLEEAKGADLLVHVVDSSHPEYR
NCTC8325 DPKTRQIQINDGFNLIISDTVGFIQKLPTTLIAAFKSTLEEAKGADLLVHVVDSSHPEYR
Newman DPKTRQIQINDGFNLIISDTVGFIQKLPTTLIAAFKSTLEEAKGADLLVHVVDSSHPEYR
USA300_FPR3757 DPKTRQIQINDGFNLIISDTVGFIQKLPTTLIAAFKSTLEEAKGADLLVHVVDSSHPEYR
************************************************************
COL TQYDTVNDLIKQLDMSHISQIVIFNKKDLCDHASNRPASDLPNVFVSSKNDGDKLLVKTL
N315 TQYDTVNDLIKQLDMSHISQIVIFNKKDLCDHASNRPASDLPNVFVSSKNDGDKLLVKTL
NCTC8325 TQYDTVNDLIKQLDMSHISQIVIFNKKDLCDHASNRPASDLPNVFVSSKNDGDKLLVKTL
Newman TQYDTVNDLIKQLDMSHISQIVIFNKKDLCDHASNRPASDLPNVFVSSKNDGDKLLVKTL
USA300_FPR3757 TQYDTVNDLIKQLDMSHISQIVIFNKKDLCDHASNRPASDLPNVFVSSKNDGDKLLVKTL
************************************************************
COL FIDEIKRQLTYYDETIATNNADRLYFLKQHTLVTELKYDEIENVYRIKGFKK
N315 FIDEIKRQLTYYDETIATNNADRLYFLKQHTLVTELKYDEIENVYRIKGFKK
NCTC8325 FIDEIKRQLTYYDETIATNNADRLYFLKQHTLVTELKYDEIENVYRIKGFKK
Newman FIDEIKRQLTYYDETIATNNADRLYFLKQHTLVTELKYDEIENVYRIKGFKK
USA300_FPR3757 FIDEIKRQLTYYDETIATNNADRLYFLKQHTLVTELKYDEIENVYRIKGFKK
****************************************************
- ↑ Arnab Basu, Mee-Ngan F Yap
Disassembly of the Staphylococcus aureus hibernating 100S ribosome by an evolutionarily conserved GTPase.
Proc Natl Acad Sci U S A: 2017, 114(39);E8165-E8173
[PubMed:28894000] [WorldCat.org] [DOI] (I p)Daniel J Bennison, Jose A Nakamoto, Timothy D Craggs, Pohl Milón, John B Rafferty, Rebecca M Corrigan
The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions.
mBio: 2021, 12(6);e0267921
[PubMed:34749534] [WorldCat.org] [DOI] (I p)