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Summary[edit | edit source]

  • pan ID?: SAUPAN003914000
  • symbol?: asnC
  • synonym:
  • description?: asparagine--tRNA ligase

      descriptions from strain specific annotations:

    • asparagine--tRNA ligase
    • asparaginyl-tRNA synthetase
    • asparaginyl-tRNA synthetase, putative
    • putative asparaginyl-tRNA synthetase
  • strand?: -
  • coordinates?: 4232396..4233688
  • synteny block?: BlockID0029600
  • occurrence?: in 100% of 33 strains

asnC (asnRS): asparaginyl-tRNA synthetase [1]

Orthologs[edit | edit source]

    COL:
    SACOL1494 (asnC)
    N315:
    SA1287 (asnC)
    NCTC8325:
    Newman:
    NWMN_1365 (asnC)
    USA300_FPR3757:
    04-02981:
    SA2981_1410 (asnS)
    08BA02176:
    C248_1494 (asnS)
    11819-97:
    MS7_1410 (asnS)
    6850:
    RSAU_001326 (asnS)
    71193:
    ST398NM01_1454
    ECT-R 2:
    ECTR2_1308 (asnS)
    ED133:
    SAOV_1462 (asnS)
    ED98:
    SAAV_1441 (asnC)
    HO 5096 0412:
    SAEMRSA15_13150 (asnS)
    JH1:
    SaurJH1_1542 (asnC)
    JH9:
    SaurJH9_1513 (asnC)
    JKD6008:
    SAA6008_01423 (asnC)
    JKD6159:
    SAA6159_01319 (asnC)
    LGA251:
    SARLGA251_13680 (asnS)
    M013:
    M013TW_1402
    MRSA252:
    SAR1465 (asnC)
    MSHR1132:
    SAMSHR1132_12940
    MSSA476:
    SAS1397 (asnC)
    Mu3:
    SAHV_1442 (asnC)
    Mu50:
    SAV1454 (asnC)
    MW2:
    MW1344 (asnC)
    RF122:
    SAB1318c (asnC)
    ST398:
    SAPIG1454 (asnS)
    T0131:
    SAT0131_01543
    TCH60:
    HMPREF0772_11750 (asnS)
    TW20:
    SATW20_14530 (asnS)
    USA300_TCH1516:
    USA300HOU_1392 (asnC)
    VC40:
    SAVC_06525 (asnC)

Genome Viewer[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLA
    N315            MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLA
    NCTC8325        MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLA
    Newman          MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLA
    USA300_FPR3757  MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLA
                    ************************************************************

    COL             KEITQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLW
    N315            KEIAQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLW
    NCTC8325        KEITQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLW
    Newman          KEITQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLW
    USA300_FPR3757  KEITQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLW
                    ***:********************************************************

    COL             LRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFL
    N315            LRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFL
    NCTC8325        LRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFL
    Newman          LRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFL
    USA300_FPR3757  LRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFL
                    ************************************************************

    COL             SQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQ
    N315            SQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQ
    NCTC8325        SQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQ
    Newman          SQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQ
    USA300_FPR3757  SQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQ
                    ************************************************************

    COL             YVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDF
    N315            YVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDF
    NCTC8325        YVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDF
    Newman          YVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDF
    USA300_FPR3757  YVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDF
                    ************************************************************

    COL             GAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSER
    N315            GAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSER
    NCTC8325        GAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSER
    Newman          GAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSER
    USA300_FPR3757  GAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSER
                    ************************************************************

    COL             VDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAP
    N315            VDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAP
    NCTC8325        VDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAP
    Newman          VDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAP
    USA300_FPR3757  VDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAP
                    ************************************************************

    COL             FPRLLNRLYP
    N315            FPRLLNRLYP
    NCTC8325        FPRLLNRLYP
    Newman          FPRLLNRLYP
    USA300_FPR3757  FPRLLNRLYP
                    **********

  1. Stefani R Mladenova, Kathryn R Stein, Lianne Bartlett, Kelly Sheppard
    Relaxed tRNA specificity of the Staphylococcus aureus aspartyl-tRNA synthetase enables RNA-dependent asparagine biosynthesis.
    FEBS Lett: 2014, 588(9);1808-12
    [PubMed:24685427] [WorldCat.org] [DOI] (I p)