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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN004092000
- symbol?: —
- synonym:
- description?: hypothetical protein
- strand?: -
- coordinates?: 4369417..4370007
- synteny block?: BlockID0031220
- occurrence?: in 26% of 34 strains
ietR : ICE6013 excision and transfer repressor [1]
Some staphylococci have acquired a Type IV secretion system encoded on an integrative conjugative element (ICE6013), which encodes a minimal conjugative transfer function that may have adapted to double as a small molecule translocation system. IetR is a poorly-characterized repressor of ICE excision and transfer analogous conceptually to ICESXTSetR, although probably the closest analogue would be TrbF from conjugative plasmid RP4 with which it shares homology. How these proteins function to repress ICE excision and transfer is unknown although IetR is reported to have a low-homology GlmU-like domain.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_12380
JH1:
—
JH9:
—
JKD6008:
SAA6008_02632
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR1289
MSHR1132:
SAMSHR1132_15380
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
SAT0131_02807 (thrA)
TCH60:
—
TW20:
SATW20_27140
USA300_TCH1516:
USA300HOU_0627
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKQKIIMFTLVTVILFCAVLIGYQIPKQQVKMKQNQIEDLQEEQRILRDKNGELNKLVKR
USA300_FPR3757 MKQKIIMFTLVTVILFCAVLIGYQIPKQQVKMKQNQIEDLQEEQRILRDKNGELNKLVKR
************************************************************
COL QSKTVISDEEKQIREVSSNFVKQMFEMKKDSSFKSKAPQIKPLVTKDYYDTLFKDSKDKY
USA300_FPR3757 QSKTVISDEEKQIREVSSNFVKQMFEMKKDSSFKSKAPQIKPLVTKDYYDTLFKDSKDKY
************************************************************
COL DLYDDITVNDIHVYFDTYDPKKDSYKVFVQFDERIETDGDDKIEHRQTSAQLDLVRTAEG
USA300_FPR3757 DLYDDITVNDIHVYFDTYDPKKDSYKVFVQFDERIETDGDDKIEHRQTSAQLDLVRTAEG
************************************************************
COL WRIDNLKRFNLKPLGR
USA300_FPR3757 WRIDNLKRFNLKPLGR
****************
- ↑ J Haase, R Lurz, A M Grahn, D H Bamford, E Lanka
Bacterial conjugation mediated by plasmid RP4: RSF1010 mobilization, donor-specific phage propagation, and pilus production require the same Tra2 core components of a proposed DNA transport complex.
J Bacteriol: 1995, 177(16);4779-91
[PubMed:7642506] [WorldCat.org] [DOI] (P p)Zita Nagy, Mónika Szabó, Michael Chandler, Ferenc Olasz
Analysis of the N-terminal DNA binding domain of the IS30 transposase.
Mol Microbiol: 2004, 54(2);478-88
[PubMed:15469518] [WorldCat.org] [DOI] (P p)Davida S Smyth, D Ashley Robinson
Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.
J Bacteriol: 2009, 191(19);5964-75
[PubMed:19648240] [WorldCat.org] [DOI] (I p)Minny Bhatty, Jenny A Laverde Gomez, Peter J Christie
The expanding bacterial type IV secretion lexicon.
Res Microbiol: 2013, 164(6);620-39
[PubMed:23542405] [WorldCat.org] [DOI] (I p)Christopher M Johnson, Alan D Grossman
Integrative and Conjugative Elements (ICEs): What They Do and How They Work.
Annu Rev Genet: 2015, 49;577-601
[PubMed:26473380] [WorldCat.org] [DOI] (I p)Emily A Sansevere, Xiao Luo, Joo Youn Park, Sunghyun Yoon, Keun Seok Seo, D Ashley Robinson
Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus.
J Bacteriol: 2017, 199(8);
[PubMed:28138100] [WorldCat.org] [DOI] (I e)