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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

Summary[edit | edit source]

  • pan ID?: SAUPAN004092000
  • symbol?:
  • synonym:
  • description?: hypothetical protein
  • strand?: -
  • coordinates?: 4369417..4370007
  • synteny block?: BlockID0031220
  • occurrence?: in 26% of 34 strains

ietR : ICE6013 excision and transfer repressor [1]

Some staphylococci have acquired a Type IV secretion system encoded on an integrative conjugative element (ICE6013), which encodes a minimal conjugative transfer function that may have adapted to double as a small molecule translocation system. IetR is a poorly-characterized repressor of ICE excision and transfer analogous conceptually to ICESXTSetR, although probably the closest analogue would be TrbF from conjugative plasmid RP4 with which it shares homology. How these proteins function to repress ICE excision and transfer is unknown although IetR is reported to have a low-homology GlmU-like domain.

Orthologs[edit | edit source]

    COL:
    N315:
    NCTC8325:
    Newman:
    USA300_FPR3757:
    04-02981:
    08BA02176:
    11819-97:
    6850:
    71193:
    ECT-R 2:
    ED133:
    ED98:
    HO 5096 0412:
    SAEMRSA15_12380
    JH1:
    JH9:
    JKD6008:
    SAA6008_02632
    JKD6159:
    JSNZ:
    LGA251:
    M013:
    MRSA252:
    SAR1289
    MSHR1132:
    SAMSHR1132_15380
    MSSA476:
    Mu3:
    Mu50:
    MW2:
    RF122:
    ST398:
    T0131:
    SAT0131_02807 (thrA)
    TCH60:
    TW20:
    SATW20_27140
    USA300_TCH1516:
    USA300HOU_0627
    VC40:

Genome Viewer[edit | edit source]

COL
USA300_FPR3757

Alignments[edit | edit source]

  • alignment of orthologues:
    CLUSTAL format alignment by MAFFT L-INS-i (v7.307)


    COL             MKQKIIMFTLVTVILFCAVLIGYQIPKQQVKMKQNQIEDLQEEQRILRDKNGELNKLVKR
    USA300_FPR3757  MKQKIIMFTLVTVILFCAVLIGYQIPKQQVKMKQNQIEDLQEEQRILRDKNGELNKLVKR
                    ************************************************************

    COL             QSKTVISDEEKQIREVSSNFVKQMFEMKKDSSFKSKAPQIKPLVTKDYYDTLFKDSKDKY
    USA300_FPR3757  QSKTVISDEEKQIREVSSNFVKQMFEMKKDSSFKSKAPQIKPLVTKDYYDTLFKDSKDKY
                    ************************************************************

    COL             DLYDDITVNDIHVYFDTYDPKKDSYKVFVQFDERIETDGDDKIEHRQTSAQLDLVRTAEG
    USA300_FPR3757  DLYDDITVNDIHVYFDTYDPKKDSYKVFVQFDERIETDGDDKIEHRQTSAQLDLVRTAEG
                    ************************************************************

    COL             WRIDNLKRFNLKPLGR
    USA300_FPR3757  WRIDNLKRFNLKPLGR
                    ****************

  1. J Haase, R Lurz, A M Grahn, D H Bamford, E Lanka
    Bacterial conjugation mediated by plasmid RP4: RSF1010 mobilization, donor-specific phage propagation, and pilus production require the same Tra2 core components of a proposed DNA transport complex.
    J Bacteriol: 1995, 177(16);4779-91
    [PubMed:7642506] [WorldCat.org] [DOI] (P p)
    Zita Nagy, Mónika Szabó, Michael Chandler, Ferenc Olasz
    Analysis of the N-terminal DNA binding domain of the IS30 transposase.
    Mol Microbiol: 2004, 54(2);478-88
    [PubMed:15469518] [WorldCat.org] [DOI] (P p)
    Davida S Smyth, D Ashley Robinson
    Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.
    J Bacteriol: 2009, 191(19);5964-75
    [PubMed:19648240] [WorldCat.org] [DOI] (I p)
    Minny Bhatty, Jenny A Laverde Gomez, Peter J Christie
    The expanding bacterial type IV secretion lexicon.
    Res Microbiol: 2013, 164(6);620-39
    [PubMed:23542405] [WorldCat.org] [DOI] (I p)
    Christopher M Johnson, Alan D Grossman
    Integrative and Conjugative Elements (ICEs): What They Do and How They Work.
    Annu Rev Genet: 2015, 49;577-601
    [PubMed:26473380] [WorldCat.org] [DOI] (I p)
    Emily A Sansevere, Xiao Luo, Joo Youn Park, Sunghyun Yoon, Keun Seok Seo, D Ashley Robinson
    Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus.
    J Bacteriol: 2017, 199(8);
    [PubMed:28138100] [WorldCat.org] [DOI] (I e)