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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159JSNZLGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN004100000
- symbol?: —
- synonym:
- description?: conjugal transfer protein
- strand?: -
- coordinates?: 4379152..4380207
- synteny block?: BlockID0031300
- occurrence?: in 26% of 34 strains
virB8 : ICE6013 extracellular channel protein VirB8 [1]
Some staphylococci have acquired a Type IV secretion system encoded on an integrative conjugative element (ICE6013), which encodes a minimal conjugative transfer function that may have adapted to double as a small molecule translocation system. VirB8 assembles into an extracellular channel through which effectors can translocate. Specifically, it spans the staphylococcal cell wall using the VirB1 hydrolase to degrade the cell wall and host recognition factors to mediate attachment to the target cell.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_12290
JH1:
—
JH9:
—
JKD6008:
SAA6008_02639
JKD6159:
—
JSNZ:
—
LGA251:
—
M013:
—
MRSA252:
SAR1296
MSHR1132:
SAMSHR1132_15270
MSSA476:
—
Mu3:
—
Mu50:
—
MW2:
—
RF122:
—
ST398:
—
T0131:
SAT0131_02814
TCH60:
—
TW20:
SATW20_27210
USA300_TCH1516:
USA300HOU_0634
VC40:
—
⊟Genome Viewer[edit | edit source]
| COL | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKIISKYILTRFSKNGKHFDIPKEQRRVIPKFKNRRKMIVICFYSLLAILLILLLASFIK
USA300_FPR3757 MKIISKYILTRFSKNGKHFDIPKEQRRVIPKFKNRRKMIVICFYSLLAILLILLLASFIK
************************************************************
COL ATRANNDSKEAVNKTNMIQKKYEDNANTVQYSPKLKLYADKFIDTYMNISKDSKELESRE
USA300_FPR3757 ATRANNDSKEAVNKTNMIQKKYEDNANTVQYSPKLKLYADKFIDTYMNISKDSKELESRE
************************************************************
COL KELLKYFPSDYKKPDEKISDTERKLNSKEFYNIKRKDKQTIIQYIVNYDVNITEKKEVKV
USA300_FPR3757 KELLKYFPSDYKKPDEKISDTERKLNSKEFYNIKRKDKQTIIQYIVNYDVNITEKKEVKV
************************************************************
COL KKKKKSEKDKDEYETKTEEKQRKVNQNILINIPIKSENNKYVVVEYPYFTPIPDSQLNKA
USA300_FPR3757 KKKKKSEKDKDEYETKTEEKQRKVNQNILINIPIKSENNKYVVVEYPYFTPIPDSQLNQA
**********************************************************:*
COL KMVEDNLKDNKREDNPKAKAFIEDFFNKYASSKSDDMAYLMDNPEGLEGTREVSQIREIR
USA300_FPR3757 KMVEDNLKDNKREDNPKAKAFIEDFFNKYASSKSDDMAYLMDNPEGLEGTREVSQIREIR
************************************************************
COL LYPKGDDYVAKVEILMKDKDSPLENLEHYTLDITKKDGKYYVKNMTNSIGG
USA300_FPR3757 LYPKGDDYVAKVEILMKDKDSPLENLEHYTLDITKKDGKYYVKNMTNSIGG
***************************************************
- ↑ Zita Nagy, Mónika Szabó, Michael Chandler, Ferenc Olasz
Analysis of the N-terminal DNA binding domain of the IS30 transposase.
Mol Microbiol: 2004, 54(2);478-88
[PubMed:15469518] [WorldCat.org] [DOI] (P p)Davida S Smyth, D Ashley Robinson
Integrative and sequence characteristics of a novel genetic element, ICE6013, in Staphylococcus aureus.
J Bacteriol: 2009, 191(19);5964-75
[PubMed:19648240] [WorldCat.org] [DOI] (I p)Minny Bhatty, Jenny A Laverde Gomez, Peter J Christie
The expanding bacterial type IV secretion lexicon.
Res Microbiol: 2013, 164(6);620-39
[PubMed:23542405] [WorldCat.org] [DOI] (I p)Emily A Sansevere, Xiao Luo, Joo Youn Park, Sunghyun Yoon, Keun Seok Seo, D Ashley Robinson
Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus.
J Bacteriol: 2017, 199(8);
[PubMed:28138100] [WorldCat.org] [DOI] (I e)