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⊟Summary[edit | edit source]
- pan ID?: SAUPAN004148000
- symbol?: era
- synonym:
- description?: GTP-binding protein Era
- GTP-binding protein Era
- GTPase Era
- GTP-binding protein era -like protein
- pseudogene
- putative GTP-binding protein
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 4417523..4418422
- synteny block?: BlockID0031780
- occurrence?: in 100% of 33 strains
era: 30S ribosome RNA degradosome hub protein and ribosome-associated GTPase Era [1]
A crystal structure is available: 9JKP
Ribosome-associated GTPases including Era, RsgA, RbgA, HflX, ObgE, EngA and EngB are widely-conserved, stringent response alarmone-responsive ribosomal assembly cofactors
• Era is a hub protein for the assembly of RNA degradosome components (YbeY, CshA) and RelA at the 30S ribosome. Alarmone binding results in complex dissolution, impaired RNA turnover and slow growth.
⊟Orthologs[edit | edit source]
04-02981:
SA2981_1525 (bex)
08BA02176:
C248_1610 (era)
11819-97:
MS7_1584 (era)
6850:
RSAU_001432 (era)
71193:
ST398NM01_1632
ECT-R 2:
ECTR2_1417 (era)
ED133:
SAOV_1567 (era)
ED98:
SAAV_1559 (era)
HO 5096 0412:
SAEMRSA15_14870 (era)
JH1:
SaurJH1_1659 (era)
JH9:
SaurJH9_1625 (era)
JKD6008:
SAA6008_01537 (era)
JKD6159:
SAA6159_01502 (era)
LGA251:
SARLGA251_14730 (era)
M013:
M013TW_1582
MRSA252:
SAR1644 (era)
MSHR1132:
SAMSHR1132_14070
MSSA476:
SAS1505 (era)
Mu3:
SAHV_1554 (era)
Mu50:
SAV1567 (era)
MW2:
MW1519 (era)
RF122:
SAB1439c (era)
ST398:
SAPIG1632 (era)
T0131:
SAT0131_01662
TCH60:
HMPREF0772_11573 (era)
TW20:
SATW20_15630 (era)
USA300_TCH1516:
USA300HOU_1568 (era)
VC40:
SAVC_07085 (era)
⊟Genome Viewer[edit | edit source]
| COL | |
| N315 | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFID
N315 MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFID
NCTC8325 MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFID
Newman MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFID
USA300_FPR3757 MTEHKSGFVSIIGRPNVGKSTFVNRVIGHKIAIMSDKAQTTRNKIQGVMTRDDAQIIFID
************************************************************
COL TPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLV
N315 TPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLV
NCTC8325 TPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLV
Newman TPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLV
USA300_FPR3757 TPGIHKPKHKLGDYMMKVAKNTLSEIDAIMFMVNANEEIGRGDEYIIEMLKNVKTPVFLV
************************************************************
COL LNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDD
N315 LNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDD
NCTC8325 LNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDD
Newman LNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDD
USA300_FPR3757 LNKIDLVHPDELMPKIEEYQSYMDFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDD
************************************************************
COL QISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQK
N315 QISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQK
NCTC8325 QISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERGSQK
Newman QISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQK
USA300_FPR3757 QISDHPEQFVVGEIIREKILHLTSEEIPHAIGVNVDRMVKESEDRVHIEATIYVERDSQK
********************************************************.***
COL GIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
N315 GIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
NCTC8325 GIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
Newman GIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
USA300_FPR3757 GIVIGKGGKKLKEVGKRARRDIEMLLGSKVYLELWVKVQRDWRNKVNFIRQIGYVEDQD
***********************************************************
- ↑ Alison Wood, Sophie E Irving, Daniel J Bennison, Rebecca M Corrigan
The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus.
PLoS Genet: 2019, 15(8);e1008346
[PubMed:31465450] [WorldCat.org] [DOI] (I e)Daniel J Bennison, Jose A Nakamoto, Timothy D Craggs, Pohl Milón, John B Rafferty, Rebecca M Corrigan
The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions.
mBio: 2021, 12(6);e0267921
[PubMed:34749534] [WorldCat.org] [DOI] (I p)Evelina Klochkova, Artem Biktimirov, Daut Islamov, Anatolii Belousov, Shamil Validov, Marat Yusupov, Konstantin Usachev
Crystal structure of the GDP-bound GTPase Era from Staphylococcus aureus.
Biochem Biophys Res Commun: 2024, 735;150852
[PubMed:39432921] [WorldCat.org] [DOI] (I p)