PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40

⊟Summary[edit | edit source]

pan ID^?: SAUPAN004584000
symbol^?: epiB
synonym:
description^?: lantibiotic epidermin biosynthesis protein EpiB
- lantibiotic epidermin biosynthesis protein EpiB
- epidermin biosynthesis protein EpiB
- lantibiotic biosynthesis protein
- pseudogene
- thiopeptide-type bacteriocin biosynthesis domain protein
strand^?: -
coordinates^?: 4819612..4824116
synteny block^?: BlockID0035600
occurrence^?: in 42% of 33 strains

bsaB: bacteriocin of Staphylococcus aureus posttranslational serine/threonine dehydratase ^[1]

⊟Orthologs[edit | edit source]

COL:

SACOL1877 (epiB)

N315:

—

NCTC8325:

SAOUHSC_01952

Newman:

NWMN_1715 (bsaB)

USA300_FPR3757:

SAUSA300_1766 (epiB)

04-02981:

—

08BA02176:

—

11819-97:

MS7_1822

6850:

—

71193:

—

ECT-R 2:

—

ED133:

SAOV_1806

ED98:

—

HO 5096 0412:

—

JH1:

—

JH9:

—

JKD6008:

—

JKD6159:

—

LGA251:

SARLGA251_17050

M013:

—

MRSA252:

—

MSHR1132:

—

MSSA476:

SAS1745

Mu3:

—

Mu50:

—

MW2:

MW1764 (bsaB)

RF122:

SAB1682c

ST398:

—

T0131:

SAT0131_01943

TCH60:

—

TW20:

SATW20_18190

USA300_TCH1516:

USA300HOU_1814 (epiB)

VC40:

SAVC_08345

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKESILTTTFNLYCTLQE
NCTC8325        MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKESILTTTFNLYCTLQE
Newman          MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKESILTTTFNLYCTLQE
USA300_FPR3757  MNTIYEPSSICMIRTPLLSVEFFNLFLNTEQIKYSDLQLNAQMKESILTTTFNLYCTLQE
                ************************************************************

COL             INFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVNEPTRLKVGNSIQKYVK
NCTC8325        INFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVNEPTRLKVGNSIQKYVK
Newman          INFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVNEPTRLKVGNSIQKYVK
USA300_FPR3757  INFDGDNKKVRDAKESLLKYLIRMSTRPTPFGLLSGINLGHFVNEPTRLKVGNSIQKYVK
                ************************************************************

COL             VDGEWLYKLVSYIESIDEYYQNLKVIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKN
NCTC8325        VDGEWLYKLVSYIESIDEYYQNLKVIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKN
Newman          VDGEWLYKLVSYIESIDEYYQNLKVIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKN
USA300_FPR3757  VDGEWLYKLVSYIESIDEYYQNLKVIWNSKAHIINDRIYLNEQSAIYLNNNKDTSFSIKN
                ************************************************************

COL             SELLVFIKTTVTNNNITFSNLAEKINQEFEINDITKVKVYIHNLVSKEIIYSTIRPPLSY
NCTC8325        SELLVFIKTTVTNNNITFSNLAEKINQEFEINDITKVKVYIHNLVSKEIIYSTIRPPLSY
Newman          SELLVFIKTTVTNNNITFSNLAEKINQEFEINDITKVKVYIHNLVSKEIIYSTIRPPLSY
USA300_FPR3757  SELLVFIKTTVTNNNITFSNLAEKINQEFEINDITKVKVYIHNLVSKEIIYSTIRPPLSY
                ************************************************************

COL             SDNLNYILNKLSLHNDDFVKKIREIQKLILAYEKTEIGFGEELYKDIIHHMKALFKCKNY
NCTC8325        SDNLNYILNKLSLHNDDFVKKIREIQKLILAYEKTEIGFGEELYKDIIHHMKALFKCKNY
Newman          SDNLNYILNKLSLHNDDFVKKIREIQKLILAYEKTEIGFGEELYKDIIHHMKALFKCKNY
USA300_FPR3757  SDNLNYILNKLSLHNDDFVKKIREIQKLILAYEKTEIGFGEELYKDIIHHMKALFKCKNY
                ************************************************************

COL             LQIDTKIDMINNYLHQDIATNISEAAYLLWLLSRNNIGFTDLKVLHNRFIEKYGFEQLVN
NCTC8325        LQIDTKIDMINNYLHQDIATNISEAAYLLWLLSRNNIGFTDLKVLHNRFIEKYGFEQLVN
Newman          LQIDTKIDMINNYLHQDIATNISEAAYLLWLLSRNNIGFTDLKVLHNRFIEKYGFEQLVN
USA300_FPR3757  LQIDTKIDMINNYLHQDIATNISEAAYLLWLLSRNNIGFTDLKVLHNRFIEKYGFEQLVN
                ************************************************************

COL             IKDLISDITGFGTTIFQEEETDGNNIVMLKQKFLHALRNNDEIVINEKDVESLINDNEIN
NCTC8325        IKDLISDITGFGTTIFQEEETDGNNIVMLKQKFLHALRNNDEIVINEKDVESLINDNEIN
Newman          IKDLISDITGFGTTIFQEEETDGNNIVMLKQKFLHALRNNDEIVINEKDVESLINDNEIN
USA300_FPR3757  IKDLISDITGFGTTIFQEEETDGNNIVMLKQKFLHALRNNDEIVINEKDVESLINDNEIN
                ************************************************************

COL             HYHAPMSADVYAELYLGRFYNQYNELIVISPLTASFNAGATFGRFHHLIDTETLAKLEHE
NCTC8325        HYHAPMSADVYAELYLGRFYNQYNELIVISPLTASFNAGATFGRFHHLIDTETLAKLEHE
Newman          HYHAPMSADVYAELYLGRFYNQYNELIVISPLTASFNAGATFGRFHHLIDTETLAKLEHE
USA300_FPR3757  HYHAPMSADVYAELYLGRFYNQYNELIVISPLTASFNAGATFGRFHHLIDTETLAKLEHE
                ************************************************************

COL             KGHYYQKMICDDNVEMISINNIPKYPRNHNVLTNHDSYEYSLNLGSSNSYSKYELTLDDI
NCTC8325        KGHYYQKMICDDNVEMISINNIPKYPRNHNVLTNHDSYEYSLNLGSSNSYSKYELTLDDI
Newman          KGHYYQKMICDDNVEMISINNIPKYPRNHNVLTNHDSYEYSLNLGSSNSYSKYELTLDDI
USA300_FPR3757  KGHYYQKMICDDNVEMISINNIPKYPRNHNVLTNHDSYEYSLNLGSSNSYSKYELTLDDI
                ************************************************************

COL             YVGATFNKLYLYSSQLNKRVIFESNNMYNFLKECNLYRLLREISMESVKCIEPMNDVSID
NCTC8325        YVGATFNKLYLYSSQLNKRVLFESNNMYNFLKECNLYRLLREISMESVKCIEPMNDVSID
Newman          YVGATFNKLYLYSSQLNKRVLFESNNMYNFLKECNLYRLLREISMESVKCIEPMNDVSID
USA300_FPR3757  YVGATFNKLYLYSSQLNKRVLFESNNMYNFLKECNLYRLLREISMESVKCIEPMNDVSID
                ********************:***************************************

COL             SFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEWDQQFLKYQEQFNIPNIVNLVYGDNK
NCTC8325        SFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEWDQQFLKYQEQFNIPNIVNLVYGDNK
Newman          SFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEWDQQFLKYQEQFNIPNIVNLVYGDNK
USA300_FPR3757  SFSYSPRIRYKNVILKPAYWKINEMVLPLPKNEEWDQQFLKYQEQFNIPNIVNLVYGDNK
                ************************************************************

COL             LLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQSKNDHVYEIVTPIYKKSSYRGPEIEIP
NCTC8325        LLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQSKNDHVYEIVTPIYKKSSYRGPEIEIP
Newman          LLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQSKNDHVYEIVTPIYKKSSYRGPEIEIP
USA300_FPR3757  LLLNLSLANHRYLLMKEYKKHKRVRLVESFLPQSKNDHVYEIVTPIYKKSSYRGPEIEIP
                ************************************************************

COL             KYKNTDIEYDKDWFALHIHIDKPSQDTFIIDNLYPFVKHLKDKGDIDQYFLMRYIKQGDI
NCTC8325        KYKNTDIEYDKDWFALHIHIDKPSQDTFIIDNLYPFVKHLKDKGDIDQYFLMRYIKQGDI
Newman          KYKNTDIEYDKDWFALHIHIDKPSQDTFIIDNLYPFVKHLKDKGDIDQYFLMRYIKQGDI
USA300_FPR3757  KYKNTDIEYDKDWFALHIHIDKPSQDTFIIDNLYPFVKHLKDKGDIDQYFLMRYIKQGDI
                ************************************************************

COL             LKLRLFRNDENYAEIYSILKNWLPHVRQTTEVSDYEFVSYEPEFFRYGGKNTINEIEAFF
NCTC8325        LKLRLFRNDENYAEIYSILKNWLPHVRQTTEVSDYEFVSYEPEFFRYGGKNTINEIEAFF
Newman          LKLRLFRNDENYAEIYSILKNWLPHVRQTTEVSDYEFVSYEPEFFRYGGKNTINEIEAFF
USA300_FPR3757  LKLRLFRNDENYAEIYSILKNWLPHVRQTTEVSDYEFVSYEPEFFRYGGKNTINEIEAFF
                ************************************************************

COL             EYDTNLAVNIIENDFKFDRPYIVAISIMYLFEMFSISNEERMEIVNNYVPTSFKSKDIRP
NCTC8325        EYDTNLAVNIIENDFKFDRPYIVAISIMYLFEMFSISNEERMEIVNNYVPTSFKSKDIRP
Newman          EYDTNLAVNIIENDFKFDRPYIVAISIMYLFEMFSISNEERMEIVNNYVPTSFKSKDIRP
USA300_FPR3757  EYDTNLAVNIIENDFKFDRPYIVAISIMYLFEMFSISNEERMEIVNNYVPTSFKSKDIRP
                ************************************************************

COL             FKNELVTICNPANNFEYMAKHYSGIYRILKDGNQILSKLNEGLKKTLTTKRSRIIGSLIH
NCTC8325        FKNELVTICNPANNFEYMAKHYSGIYRILKDGNQILSKLNEGLKKTLTTKRSRIIGSLIH
Newman          FKNELVTICNPANNFEYMAKHYSGIYRILKDGNQILSKLNEGLKKTLTTKRSRIIGSLIH
USA300_FPR3757  FKNELVTICNPANNFEYMAKHYSGIYRILKDGNQILSKLNEGLKKTLTTKRSRIIGSLIH
                ************************************************************

COL             MRCNRIFGIDKDQETFVLSIVKEIVKTQKHWCGDKND
NCTC8325        MRCNRIFGIDKDQETFVLSIVKEIVKTQKHWCGDKND
Newman          MRCNRIFGIDKDQETFVLSIVKEIVKTQKHWCGDKND
USA300_FPR3757  MRCNRIFGIDKDQETFVLSIVKEIVKTQKHWCGDKND
                *************************************

↑ Karen M Daly, Mathew Upton, Stephanie K Sandiford, Lorraine A Draper, Philip A Wescombe, Ralph W Jack, Paula M O'Connor, Angela Rossney, Friedrich Götz, Colin Hill, Paul D Cotter, R Paul Ross, John R Tagg
Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.
J Bacteriol: 2010, 192(4);1131-42
[PubMed:20023032] [WorldCat.org] [DOI] (I p)Leon D Kluskens, Anneke Kuipers, Rick Rink, Esther de Boef, Susan Fekken, Arnold J M Driessen, Oscar P Kuipers, Gert N Moll
Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin.
Biochemistry: 2005, 44(38);12827-34
[PubMed:16171398] [WorldCat.org] [DOI] (P p)

[1] Karen M Daly, Mathew Upton, Stephanie K Sandiford, Lorraine A Draper, Philip A Wescombe, Ralph W Jack, Paula M O'Connor, Angela Rossney, Friedrich Götz, Colin Hill, Paul D Cotter, R Paul Ross, John R Tagg
Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.
J Bacteriol: 2010, 192(4);1131-42
[PubMed:20023032] [WorldCat.org] [DOI] (I p)Leon D Kluskens, Anneke Kuipers, Rick Rink, Esther de Boef, Susan Fekken, Arnold J M Driessen, Oscar P Kuipers, Gert N Moll
Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin.
Biochemistry: 2005, 44(38);12827-34
[PubMed:16171398] [WorldCat.org] [DOI] (P p)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]