⊟Summary[edit | edit source]

pan ID^?: SAUPAN004921000
symbol^?: rumA
synonym:
description^?: RNA methyltransferase
- RNA methyltransferase
- 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD
- RNA methyltransferase TrmA family protein
- 23S rRNA (uracil-5-)-methyltransferase RumA
- 23S rRNA m(5)U1939 methyltransferase
- putative RNA methyltransferase
- RNA methyltransferase, TrmA family
- RNA methyltransferase-like protein
- rRNA methyltransferase RumA
- TrmA family RNA methyltransferase
- Uncharacterized RNA methyltransferase
strand^?: -
coordinates^?: 5109944..5111305
synteny block^?: BlockID0038270
occurrence^?: in 100% of 34 strains

rlmCD (rumA): ribosome large subunit methyltransferase CD ^[1]

Ribosome large subunit methyltransferase CD (alt: ribosomal uridine methyltransferase A, ribosome large subunit nucleobase methyltransferase CD, 23S rRNA uridine(792)-, uridine(1966)-C-(5)-methyltransferase) attaches a methyl group to the uridine nucleobase 5-position of residues 792 and 1966 in 23S ribosomal RNA (S. aureus numbering; uridines 747 and 1939 by E. coli numbering).

23S rRNA : U (792) → m5U (792), U (1966) → m5U (1966)

⊟Orthologs[edit | edit source]

COL:

N315:

NCTC8325:

Newman:

USA300_FPR3757:

SAUSA300_1878 (rumA)

04-02981:

SA2981_1853

08BA02176:

C248_1971

11819-97:

MS7_1932 (rumA)

6850:

RSAU_001784

71193:

ST398NM01_1990

ECT-R 2:

ECTR2_1768 (rumA)

ED133:

SAOV_1996

ED98:

SAAV_1963 (rumA)

HO 5096 0412:

SAEMRSA15_18040

JH1:

SaurJH1_1985

JH9:

SaurJH9_1951

JKD6008:

SAA6008_01917

JKD6159:

SAA6159_01828

JSNZ:

JSNZ_001928 (rlmD)

LGA251:

SARLGA251_17790

M013:

M013TW_1933

MRSA252:

SAR1988

MSHR1132:

SAMSHR1132_17420

MSSA476:

SAS1819

Mu3:

SAHV_1882

Mu50:

SAV1897

MW2:

MW1838

RF122:

SAB1829c

ST398:

SAPIG1990 (rumA)

T0131:

SAT0131_02022 (gap)

TCH60:

HMPREF0772_11246 (rumA)

TW20:

SATW20_18910

USA300_TCH1516:

USA300HOU_1896

VC40:

SAVC_08745

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

alignment of orthologues:
CLUSTAL format alignment by MAFFT L-INS-i (v7.307)

COL             MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLL
N315            MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLL
NCTC8325        MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLL
Newman          MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLL
USA300_FPR3757  MQAIAKNDIKTGTVVDLTHEGHGVVKIDRFPIFIPQALINEQIEYKIIKVKKNFAIGKLL
                ************************************************************

COL             NINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTV
N315            NINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTV
NCTC8325        NINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTV
Newman          NINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTV
USA300_FPR3757  NINTRSENRVAPPCIYYERCGGCQLQHLSYEAQLEMKKEQVINLFQRKAHFDNSKINDTV
                ************************************************************

COL             GMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMNEVKSIL
N315            GMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMNEVKSIL
NCTC8325        GMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMNEVKSIL
Newman          GMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMNEVKSIL
USA300_FPR3757  GMTDPWRYRNKSQIPVGKNEQNEVIMGFYRQRSHDIIDMESCLIQDSQHQEVMNEVKSIL
                ************************************************************

COL             KDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMIIFVTNGKKWPQKNAVVEKILDAFPNVT
N315            KDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMIIFVTNGKKWPQKNAVVEKILDAFPNVT
NCTC8325        KDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMIIFVTNGKKWPQKNAVVEKILDAFPNVT
Newman          KDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMIIFVTNGKKWPQKNAVVEKILDAFPNVT
USA300_FPR3757  KDLNVSIYQEQLKKGLMRHLVVRTGYHTDEMMIIFVTNGKKWPQKNAVVEKILDAFPNVT
                ************************************************************

COL             SIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAI
N315            SIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAI
NCTC8325        SIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAI
Newman          SIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAI
USA300_FPR3757  SIKQNINDSHSNVIMGRQSITLYGKDTIIDQLTDSTFKISDQSFYQINSEQTEKLYNKAI
                ************************************************************

COL             EYAQLTGNEVVLDTYCGIGTIGLYMAPLAKHVYGVEVVPSAIEDAQQNATINQCNNTTFV
N315            EYAQLTGNEVVLDTYCGIGTIGLYMAPHAKHVYGVEVVPSSIEDAQQNATINQCNNTTFV
NCTC8325        EYAQLTGNEVVLDTYCGIGTIGLYMAPLAKHVYGVEVVPSAIEDAQQNATINQCNNTTFV
Newman          EYAQLTGNEVVLDTYCGIGTIGLYMAPLAKHVYGVEVVPSAIEDAQQNATINQCNNTTFV
USA300_FPR3757  EYAQLTGNEVVLDTYCGIGTIGLYMAPLAKHVYGVEVVPSAIEDAQQNATINQCNNTTFV
                *************************** ************:*******************

COL             CGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDA
N315            CGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDA
NCTC8325        CGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDA
Newman          CGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDA
USA300_FPR3757  CGKAEEVILQWKAQGIKPDVVMVDPPRKGCDETFIQTLLTLEPKRIVYISCNPATQQRDA
                ************************************************************

COL             LLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
N315            LLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
NCTC8325        LLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
Newman          LLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
USA300_FPR3757  LLLAEKYQLEEVTPVDMFPQTTHVETVALFNLK
                *********************************

↑ Benoit Desmolaize, Céline Fabret, Damien Brégeon, Simon Rose, Henri Grosjean, Stephen Douthwaite
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA.
Nucleic Acids Res: 2011, 39(21);9368-75
[PubMed:21824914] [WorldCat.org] [DOI] (I p)Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
FEBS Lett: 2020, 594(21);3551-3567
[PubMed:32852796] [WorldCat.org] [DOI] (I p)Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
Sci Rep: 2024, 14(1);14253
[PubMed:38902339] [WorldCat.org] [DOI] (I e)

[1] Benoit Desmolaize, Céline Fabret, Damien Brégeon, Simon Rose, Henri Grosjean, Stephen Douthwaite
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA.
Nucleic Acids Res: 2011, 39(21);9368-75
[PubMed:21824914] [WorldCat.org] [DOI] (I p)Alexander Golubev, Bulat Fatkhullin, Iskander Khusainov, Lasse Jenner, Azat Gabdulkhakov, Shamil Validov, Gulnara Yusupova, Marat Yusupov, Konstantin Usachev
Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution.
FEBS Lett: 2020, 594(21);3551-3567
[PubMed:32852796] [WorldCat.org] [DOI] (I p)Adrián González-López, Daniel S D Larsson, Ravi Kiran Koripella, Brett N Cain, Martin Garcia Chavez, Paul J Hergenrother, Suparna Sanyal, Maria Selmer
Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane.
Sci Rep: 2024, 14(1);14253
[PubMed:38902339] [WorldCat.org] [DOI] (I e)

[1]

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Contents

⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]

COL
N315
NCTC8325
Newman
USA300_FPR3757

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⊟Summary[edit | edit source]

⊟Orthologs[edit | edit source]

⊟Genome Viewer[edit | edit source]

⊟Alignments[edit | edit source]