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PangenomeCOLN315NCTC8325NewmanUSA300_FPR375704-0298108BA0217611819-97685071193ECT-R 2ED133ED98HO 5096 0412JH1JH9JKD6008JKD6159LGA251M013MRSA252MSHR1132MSSA476MW2Mu3Mu50RF122ST398T0131TCH60TW20USA300_TCH1516VC40
⊟Summary[edit | edit source]
- pan ID?: SAUPAN005197000
- symbol?: —
- synonym:
- description?: tetracenomycin polyketide synthesis O-methyltransferase TcmP
- tetracenomycin polyketide synthesis O-methyltransferase TcmP
- pseudogene
- tetracenomycin polyketide synthesis O-methyltransferase, TcmP
descriptions from strain specific annotations:
- strand?: -
- coordinates?: 5363959..5367269
- synteny block?: BlockID0040290
- occurrence?: in 33% of 33 strains
spm : staphylococcal pyochelin methyltransferase [1]
Staphylococci and Pseudomonas can cause mixed infections in the same niche (lung, wound) where Pseudomonas limits staphylococcal growth with its siderophore pyochelin. Spm methylates pyochelin and restores staphylococcal growth in mixed infection models.
⊟Orthologs[edit | edit source]
04-02981:
—
08BA02176:
—
11819-97:
—
6850:
—
71193:
—
ECT-R 2:
—
ED133:
—
ED98:
—
HO 5096 0412:
SAEMRSA15_19300
JH1:
—
JH9:
—
JKD6008:
SAA6008_02061
JKD6159:
—
LGA251:
—
M013:
—
MRSA252:
—
MSHR1132:
—
MSSA476:
SAS1927
Mu3:
—
Mu50:
—
MW2:
MW1944
RF122:
—
ST398:
—
T0131:
—
TCH60:
—
TW20:
SATW20_20040
USA300_TCH1516:
USA300HOU_2016
VC40:
SAVC_08980
⊟Genome Viewer[edit | edit source]
| COL | |
| NCTC8325 | |
| Newman | |
| USA300_FPR3757 |
⊟Alignments[edit | edit source]
- alignment of orthologues: CLUSTAL format alignment by MAFFT L-INS-i (v7.307)
COL MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISI
NCTC8325 MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISI
Newman MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISI
USA300_FPR3757 MKQLVGIPESMLIPLIARAKEYENEKPIIKDALSKKIFDGLDDMYKNVTCDDMSQIGISI
************************************************************
COL RTVIIDCVTKRLIKDNKDLIVVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKE
NCTC8325 RTVIIDCVTKRLIKDNKDLIVVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKE
Newman RTVIIDCVTKRLIKDNKDLIVVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKE
USA300_FPR3757 RTVIIDCVTKRLIKDNKDLIVVNIGCGLDTRFQRFNKEKISWIDLDVPESIEIRKTFFKE
************************************************************
COL SNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVLMYFDESVMTQLLDTIIKKMG
NCTC8325 SNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVLMYFDESVMTQLLDTIIKKMG
Newman SNSYKMISKSMLDYSWIDDVKNYKFFNSKSDILFIIEGVLMYFDESVMTQLLDTIIKKMG
USA300_FPR3757 SNSYKMISKSMLDYSWIDDVKNYKFFNSKSNILFIIEGVLMYFDESVMTQLLDTIIKKMG
******************************:*****************************
COL DHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
NCTC8325 DHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
Newman DHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
USA300_FPR3757 DHNLTFAIEFCSKTIANNTKRHQSVSKLSSQPVFKYGYNDLKKLNEILPNTIRVIHEYNY
************************************************************
COL FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
NCTC8325 FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
Newman FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
USA300_FPR3757 FDYYKNRWGLFGYCRFIPYLKKRLNNKIVLMKYKVPKRQRH
*****************************************
- ↑ Christian Jenul, Klara C Keim, Justin N Jens, Michael J Zeiler, Katrin Schilcher, Michael J Schurr, Christian Melander, Vanessa V Phelan, Alexander R Horswill
Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections.
Cell Rep: 2023, 42(6);112540
[PubMed:37227819] [WorldCat.org] [DOI] (I p)